Relation Between Fluorodeoxyglucose Uptake and Glucose Transporter-1 Expression in Gastric Signet Ring Cell Carcinoma

Choi, Bong Hoi; Song, Hyo Sang; An, Young‐Sil; Han, Sang Uk; Kim, Jang-Hee; Yoon, Joon Kee

doi:10.1007/s13139-010-0058-4

Cited by 13 publications

(22 citation statements)

References 23 publications

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“…Korean studies have suggested that the intestinal type of gastric cancer is related to GLUT-1 [14,16,40]. Our study also obtained a similar result: multivariate analysis of overall or advanced stage gastric cancer revealed that the positive rate of GLUT-1 in intestinal gastric cancer was higher than that in the diffuse type.…”

Section: Discussionsupporting

confidence: 85%

Glucose Transporter-1 (GLUT-1) Expression is Associated with Tumor Size and Poor Prognosis in Locally Advanced Gastric Cancer

Yin

Gao

Yang

et al. 2020

Med Sci Monit Basic Res

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Background:The clinicopathological parameters associated with glucose transporter-1 (GLUT-1) expression in advanced gastric cancer are still controversial. This study aimed to determine the clinicopathological parameters and prognosis associated with GLUT-1 expression in advanced gastric cancer. Material/Methods:The GLUT-1 expression level of 234 consecutive gastric cancer samples was detected by immunohistochemical staining and evaluated by semiquantitative analysis. The clinicopathological data and expression level of GLUT-1 of enrolled patients were retrospectively analyzed with univariate and multivariate analyses. Results:Tumor size, depth of invasion, and Lauren classification were independent factors related to GLUT-1 expression (P<0.05). Within advanced gastric cancer, tumor size and Lauren type were independent factors associated with GLUT-1 (P=0.011, P<0.001, respectively). The mean survival time of GLUT-1-positive patients with stage M0 advanced gastric cancer who had undergone radical gastrectomy was shorter than that of GLUT-1negative patients (61.26±6.12 versus 80.88±7.38, P=0.044). GLUT-1 was an independent prognosis factor in locally advanced gastric cancer patients who had undergone radical gastrectomy (hazard ratio [HR] 1.769, P=0.046). The mean survival time of adjuvant chemotherapy was significantly better than no adjuvant chemotherapy in the GLUT-1-positive group (71.10±6.88 versus 24.65±8.69, P<0.001) and in the GLUT-1 negative group (87.48±7.99 versus 49.39±11.71, P<0.001). Conclusions:Tumor size and Lauren type independently affected GLUT-1 expression in advanced gastric cancer. GLUT-1 was not only related to poor prognosis but also predicted to be a metabolic biomarker for intestinal type in locally advanced gastric cancer. The relationship among GLUT-1, hepatic metastasis and chemotherapy regimens, and mechanism of chemotherapy responses related to GLUT-1 should be further investigated.

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Section: Discussionsupporting

confidence: 85%

Glucose Transporter-1 (GLUT-1) Expression is Associated with Tumor Size and Poor Prognosis in Locally Advanced Gastric Cancer

Yin

Gao

Yang

et al. 2020

Med Sci Monit Basic Res

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“…False negative PET CT is common in mucin secreting signet ring cell adeno carcinoma due to GLUT-1 transporter deficiency. Gastric signet ring cell carcinoma (GSRC) is known to have low fluorodeoxyglucose (FDG) uptake (9). Staging laparoscopy is performed prior to definitive surgery.…”

Section: Staging and Diagnosismentioning

confidence: 99%

Management of gastric cancer in Indian population

Ibrahim¹,

Gilbert²

2017

Transl. Gastroenterol. Hepatol.

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Adenocarcinoma stands the most common malignancies in the gastric carcinomas and holds a significant mortality and morbidity rates annually, due to the early vague symptoms among the population and hence the delayed presentation at advanced stages of cancer. In India the screening programs for gastric cancer has been a setback due to various logistics reasons and the data available from reporting is also not content. Our study is a review article featuring the management of gastric cancer in the Indian population. The lifestyle of India population is varied right from its southern region to its northern counterparts, which is due to its diversified culture within the country. Studies have concluded that the northern population tends to have a higher incidence comparatively and the various risk factors associated with the disease has been discussed. Management of the gastric cancer in India remains the same compared to the outside world, though the availability of endoscopic ultrasound and other technical advancements remain sparse in the field of diagnostics and staging of the disease. D2 gastrectomy remains the mainstay of surgery among the Indian population though significant number of patients are deemed inoperable on table. Neo adjuvant Chemotherapy, Radiotherapy and Targeted therapy is yet to be efficiently used across the country according to our study as there is lack of data in our registries. The incidence is decreasing in developing nations and more proximal cancers are reported. However, in India the major population-based cancer registries report an incidence decline only in Mumbai and Chennai. A shift from distal to proximal as the site of disease has not been reported from India. The contribution of the Indian scientific fraternity to the world medical literature for gastric cancer is sparse and it is clear that a lot more is to be done; the possible reason may be a busy clinical schedule or lack of initiatives. There is an urgent need for research in various aspects of gastric cancer from India including epidemiological and therapeutic areas.

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“…In gastric cancer, the degree of glucose transporter 1 (GLUT1) expression is also different in different pathological types. The expression level of GLUT1 in highly differentiated gastric cancer cells is higher than that in gastric signetring cell carcinoma, therefore, the latter has lower results for 18F-FDG uptake [23]. In addition, compared with other histological types of gastric cancer, pyruvate kinase M2 (PKM2) subtype in signet-ring cell carcinoma is at a low expression level [24].…”

Section: Discussionmentioning

confidence: 99%

Value of Maximum Standard Uptake Value as a Positron Emission Tomography/Computed Tomography Index in the Diagnosis and Prognosis of Patients with Gastric Cancer

Wang¹,

Wang²,

Zhao³

et al. 2021

Preprint

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Background: To study the application value of standard uptake value (SUVmax), a positron emission tomography/computed tomography (PET/CT) index in the diagnosis and evaluation of the prognosis of patients with gastric cancer who have not received any treatment. Methods: A retrospective analysis was made on the patients who were diagnosed to have gastric cancer at the General Hospital of Ningxia Medical University and received a PET/CT examination prior to treatment. According to different factors like sex, pathological stage, and survival time, the SUVmax in the results of 18F-labelled fluoro-2-deoxyglucose (18F-FDG) PET/CT examination was statistically compared and analysed. Results: A total of 110 newly diagnosed patients with gastric cancer were included in this study. Pathological results confirmed that there were 78 cases of gastric adenocarcinoma, 30 cases of primary gastric lymphoma and two cases of chronic atrophic gastritis. The difference between the primary gastric lymphoma group and gastric adenocarcinoma groups was statistically significant (t = 4.13, P < 0.05). In the postoperative pathological report of patients with gastric cancer, the SUVmax of stage I, stage II, stage III and stage IV were 2.89 ± 1.36, 14.09 ± 9.32, 7.36 ± 3.72, and 10.20 ± 1.91, respectively, the difference between each group was statistically significant (F = 16.10, P < 0.05).The univariate survival analysis showed that there was a significant difference in survival time between the low SUVmax and high SUVmax groups (X2 = 5.08, P < 0.05). Cox multivariate survival analysis showed that SUVmax was an independent factor affecting postoperative survival time of patients with gastric adenocarcinoma (P < 0.05). Compared with the low SUVmax group, patients in the high SUVmax group had a higher postoperative death risk than those in the low SUVmax group, hazard ration (HR) = 3.91 (95% confidence interval [CI]: 1.09-14.01). Conclusion: The index of SUVmax in PET/CT can provide a reliable semi-quantitative diagnostic value for pathological staging after gastric cancer surgery. Furthermore, SUVmax has an important reference value for the survival time of patients after gastric cancer surgery, which can better guide clinical treatment.

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Relation Between Fluorodeoxyglucose Uptake and Glucose Transporter-1 Expression in Gastric Signet Ring Cell Carcinoma

Cited by 13 publications

References 23 publications

Glucose Transporter-1 (GLUT-1) Expression is Associated with Tumor Size and Poor Prognosis in Locally Advanced Gastric Cancer

Glucose Transporter-1 (GLUT-1) Expression is Associated with Tumor Size and Poor Prognosis in Locally Advanced Gastric Cancer

Management of gastric cancer in Indian population

Value of Maximum Standard Uptake Value as a Positron Emission Tomography/Computed Tomography Index in the Diagnosis and Prognosis of Patients with Gastric Cancer

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