Relation between histopathological findings and the treatment response in lupus nephritis patients at Sohag governorate

Abstract

Background:-lupus nephritis occurs in up to 60-70 % of patients with SLE and also constitutes one of the major organ manifestations that considerably alters the course and prognosis of SLE. LN is considered a major cause that leads to renal failure, which has a major impact on the short and long-term outcomes of patients with SLE. Regimens containing immunosuppressive drugs are the main treatment for active LN and early treatment response can predict long-term prognosis, So we aim to find reliable predictors of early treatment response in patients with SLE. Finding more comprehensive parameters to develop a better treatment regimen may help decrease longer-term morbidity and mortality. Aim of the study: to examine the predictive factors of renal remission in lupus nephritis patients with lupus nephritis. Results: In our study, after diagnosis by six months, about 61% of patients achieved remission. We found that the Chronicity index and Presence of interstitial fibrosis, are reliable factors for predicting the treatment response either the responder or not at the end of the sixth month of treatment. On multivariate analysis, the Chronicity index was considered an independent predictor of disease remission after 6 months Conclusion: Chronicity index ≤ 3 was considered of significant value for detecting treatment response at the sixth.