Relation between infection with Helicobacter pylori and living conditions in childhood: evidence for person to person transmission in early life

Webb, Penelope M.; Knight, Thomas Andrew; Greaves, Sarah; Wilson, A; Newell, Diane G.; Elder, J. Bradley; Forman, David

doi:10.1136/bmj.308.6931.750

Cited by 323 publications

(205 citation statements)

References 17 publications

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“…Previously, the association of overcrowding with H. pylori positivity was consistent with interpersonal spread of infection within the home. This, along with the absence of a fixed hot water supply, had been considered a strong risk factor for infection 26 . In contrast, studies which could be seen to reflect good hygienic conditions and less crowded environments reported a much lower prevalence; less than 6 or 7% in a study carried out on 3300 German children 27 , with comparable values reported from other European countries [28][29][30] .…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Helicobacter pylori infection among Egyptian children: impact of social background and effect on growth

Mohammad¹,

Hussein²,

Coward

et al. 2008

Public Health Nutr.

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Objective: The study aim was to assess the prevalence of Helicobacter pylori infection in Egyptian schoolchildren and its effect on growth parameters. Design: A cross-sectional population-based study was conducted among 286 schoolchildren (168 boys and 118 girls), with a mean age of 11.04 6 0.19 years, to determine the prevalence of H. pylori. The presence of the bacterium was assessed using the [ 13 C]urea breath test. Relevant personal and socio-economic data on risk factors for infection were collected. Height and weight were analysed in relation to H. pylori infection. Results: The overall prevalence of H. pylori infection was 72.38%. Attending school in a socially deprived area and residing in an overcrowded home were the major risk factors for infection. Differences between infected and non-infected children were significant with regard to body weight and height (weight: 39.5 6 1.0 vs. 44.6 6 1.8 kg, P 5 0.05; height: 139.9 6 1.3 vs. 144.2 6 2.1 cm; P 5 0.009). The number of children (both boys and girls) falling below the 5th percentile of height-for-age was significantly higher in infected than non-infected children (P 5 001), similarly for Z-scores for height-for-age below -2.0 (P 5 0.003). Conclusion:The results demonstrate not only that the prevalence of H. pylori infection is extremely high among Egyptian schoolchildren, but also that the adverse effects of the infection reach far beyond the stomach. Evidence of the burden of infection on growth failure is presented.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Helicobacter pylori infection among Egyptian children: impact of social background and effect on growth

Mohammad¹,

Hussein²,

Coward

et al. 2008

Public Health Nutr.

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“…The association between stomach cancer and family size was not different in strata of age, sex, period and socioeconomic status. Helicobacter pylori is the strongest determinant of gastric cancer development, and an early acquisition of infection has been reported to be directly associated with domestic crowding and sibship size (Mendall et al, 1992;Webb et al, 1994;Blaser et al, 1995;Koch et al, 2005). Stomach cancer has been associated with low socioeconomic status and unfavourable living conditions, such as childhood deprivation (Logan, 1982;Howson et al, 1986).…”

Section: Discussionmentioning

confidence: 99%

Number of siblings and the risk of solid tumours: a nation-wide study

Altieri

Hemminki

2007

Br J Cancer

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We analysed the effects of number of siblings on the risk of solid tumours using the Swedish Family-Cancer Database, including population-based information on over 11 million individuals and more than 178 000 cancer patients diagnosed between 1958 and 2004. Incidence rate ratios (RRs), estimated by Poisson regression models, were adjusted for age, sex, birth cohort, area of residence and socioeconomic status. Having eight or more siblings vs none increased the risk of stomach cancer (RR ¼ 1.83, 95% confidence interval (CI), 1.44 -2.34). Anal cancer diagnosed before age 40 showed the strongest association with the total siblings (RR ¼ 3.27, 95% CI, 2.04 -5.26 for five or more siblings vs none). Endometrial (RR ¼ 0.76, 95% CI, 0.70 -0.82), testicular (RR ¼ 0.71, 95% CI, 0.62 -0.82), skin cancer (RR ¼ 0.82, 95% CI, 0.69 -0.97) and melanoma (RR ¼ 0.72, 95% CI, 0.65 -0.79) showed strong decreased risks for five or more siblings vs none. Prostate cancer risk for those with five or more older siblings vs none was 1.38 (95% CI, 1.23 -1.55). Having five or more younger siblings was most strongly associated with stomach cancer (RR ¼ 1.59, 95% CI, 1.29 -1.95) and melanoma (RR ¼ 0.68, 95% CI, 0.59 -0.79). We conclude that sibship characteristics are strong correlates of cancer risk at several sites; plausible interpretations include socioeconomic status.

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“…18,41,47,49,62,88,90,94,108,118,141 Vale ressaltar que as variáveis relacionadas à alta densidade de habitantes na moradia estão intimamente interligadas, dificultando a determinação de qual poderia afetar diretamente a transmissão da bactéria.…”

Section: Número De Habitantes Por Cômodo Da Casaunclassified

“…34,47,141 Webb et al 141 sugerem que crianças podem representar importante papel na transmissão do H. pylori na família. É possível que as crianças sejam não apenas mais predispostas para a infecção que os adultos como também tenham a capacidade de transmitir-lhes a infecção.…”

Section: Unidade Familiarunclassified

Aspectos epidemiológicos do Helicobacter pylori na infância e adolescência

2002

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Descritores ResumoRealizou-se revisão da epidemiologia da infecção pelo Helicobacter pylori, com o objetivo de analisar sua importância na infância e adolescência no que se refere à incidência, à prevalência, às vias de transmissão e aos fatores de risco. Para tanto, realizou-se uma pesquisa nas bases de dados Lilacs (OPS/Bireme) e Medline (National Library of Medicine) e no banco de teses da Universidade de São Paulo dos anos de 1983 a 1999. A análise da literatura levou à conclusão de que a infecção pelo Helicobacter pylori é adquirida principalmente durante a infância, apresenta aumento da prevalência com a idade, os principais fatores de riscos estão relacionados ao baixo nível socioeconômico e o mecanismo de transmissão permanece desconhecido. AbstractThe scope of the review is to study the epidemiological aspects of Helicobacter pylori infection and its importance during childhood and adolescence, focusing on incidence, prevalence, transmission and risk factors. The study's references included the following databases: LILACS (PAHO/ Bireme), MEDLINE, the US's National Library of Medicine and the thesis developed at University of São Paulo for the period 1983 to 1999. It was noted that Helicobacter pylori infection is mainly acquired during childhood, age-related prevalence, main risk factors are associated to low socioeconomic status, and its transmission mechanism remains unclear.

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Relation between infection with Helicobacter pylori and living conditions in childhood: evidence for person to person transmission in early life

Cited by 323 publications

References 17 publications

Prevalence of Helicobacter pylori infection among Egyptian children: impact of social background and effect on growth

Prevalence of Helicobacter pylori infection among Egyptian children: impact of social background and effect on growth

Number of siblings and the risk of solid tumours: a nation-wide study

Aspectos epidemiológicos do Helicobacter pylori na infância e adolescência

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