Relation between Insulin Resistance and Lipid profile in a Sample of Iraqi Type 2 Diabetic Patients

Abstract

Insulin resistance syndrome refers to a group of disorders that are more common in people who are Metabolic syndrome, one of them such as dyslipidemia. Through alterations in insulin metabolic signaling and reductions in bioavailable NO, compensatory hyperinsulinemia associated with insulin resistance contributes significantly to the pro-inflammatory, prooxidative milieu that contributes to endothelial dysfunction and compromises endothelial integrity. Objective, this study was planned to determine level in T2DM patients, and interpretation of insulin resistance HOMA-IR with lipid profile level-Methods, sixty patients and thirty controls were nvolved for this study.It is found that, insulin, FPG, HbA1c, lipid profile were measured for all subjects. It is found that (20.49vs.14.21µIU/ml) and HOMA-IR (12.60 vs.5.72) were significantly higher in patients as have elevated lipid levels. Serum insulin was found to be significantly higher in diabetic patients compared with healthy control group (P<0.0001). A significant high level of insulin resistance in diabetic groups when compared with healthy control. There is a negative correlation between HOMA-IR and HDL-C in diabetic patients. In patients group HOMA-IR