Relation between platelet indices and branch retinal vein occlusion in hypertensive patients

“…Sistemik hastalıkların yanında oküler vasküler hastalıklarda da OTH ile hastalık ilişkisi çalışılmıştır. Retinal ven tıkanıklıkları ile OTH arasındaki ilişkiyi inceleyen çalışmalarda OTH değerlerinin kontrol olgularına göre daha yüksek olduğu saptanmıştır [5,14]. Bu çalışmalarda OTH'nin retinal ven tıkanıklıklarının tahmin edilmesinde belirteç olabileceği öne sürülmüştür.…”

Section: Introductionunclassified

Mean platelet volume in patients with retinopathy of prematurity

Yüksel

Şahin²,

Şahin³

et al. 2014

J Clin Exp Invest

View full text Add to dashboard Cite

Objective: We aimed to evaluate the mean platelet volume (MPV) in patients with retinopathy of prematurity (ROP) with respect to development of type 1 ROP Methods: The medical records of the premature infants were evaluated. Babies with a birth weight under 1500 g and a gestational age under 32 weeks were enrolled to the study. Birth weight, gestational age, onset and grade of retinopathy, presence of plus disease were analyzed. At the time of type 1 ROP diagnosis, blood samples were obtained. In the patients without type 1 ROP the blood samples were also obtained at similar gestational age. Hemoglobin, hematocrit, platelet count, and MPV results were recorded. Results: Sixty-three infants were studied. 22 of them had type 1 ROP and 41 had not developed type 1 ROP. The mean gestational age and the mean birth weight between groups were not statistically significant. The mean MPV values in patients with type 1 ROP and without type 1 ROP was 9,1±2,0 fL and 9,4±1,8 fL, respectively (p=0.61). Conclusion: The results demonstrated that MPV values were not associated with severity of ROP in our study population.

show abstract

“…In our study, the MPV values in RVO patients were also higher than in the control group but not statistically significant. However, a few studies reported that the MPV values were significantly higher in patients with RVO [18, 35], and inconsistent results were also reported where the MPV was significantly lower in patients with RVO than the control group [19]. Therefore, we expect future studies to confirm the relationship between MPV and patients with NVG secondary to RVO.…”

Section: Discussionmentioning

confidence: 84%

Role of Platelet Parameters on Neovascular Glaucoma: A Retrospective Case-Control Study in China

Cao

Sun

2016

PLoS ONE

View full text Add to dashboard Cite

PurposeRetinal vein occlusion (RVO) and diabetic retinopathy (DR) are two major sight-threatening diseases which may lead to neovascular glaucoma (NVG). The aim of this study was to explore the association between platelet parameters and NVG.MethodsA total of 185 subjects were enrolled for the study from January, 2012 to December, 2015 at the Eye-ENT Hospital of Fudan University. Patients include those with NVG secondary to RVO (RVO group, n = 38), patients with NVG secondary to DR (DR group, n = 47), diabetics mellitus without retinopathy (DM group, n = 52), and healthy individuals (control group, n = 48). A complete ophthalmological examination including visual field examination, A-scan ultrasound, Fundus photography, and measurement of platelet parameters were performed for NVG subjects.ResultsThere was no statistical difference in the mean age and gender among the RVO, DR, and control groups (p>0.05). The mean level of platelet distribution width (PDW) was higher (p<0.001) in the RVO group (15.16±2.13fl) and DR group (16.17±1.66fl) when compared with the control group (13.77±2.99fl). The mean plateletcrit (PCT) value of the RVO group (0.229±0.063%) was also higher (p = 0.049) than the control group (0.199±0.045). In the DR group, mean platelet volume (MPV) value (10.72±1.57fl) was significantly higher (p = 0.002) than the control group (9.75±0.89fl). A similar trend was observed when platelet parameters were compared among the 3 groups with respect to age. The mean level of PDW was significantly higher (p<0.001) in the DR group (16.17±1.66fl) compared with the DM group (13.80±3.32fl). Stepwise multiple logistic regression analysis revealed that PDW (OR = 1.44, 95%CI = 1.149–1.805, p = 0.002) and MPV (OR = 1.503, 95%CI = 1.031–2.192, p = 0.034) were associated with the DR group, PDW (OR = 1.207, 95%CI = 1.010–1.443, p = 0.039) and PCT (OR = 1.663, 95%CI = 1.870–2.654, p = 0.036) were associated with the RVO group.ConclusionOur results suggest that increased PDW and MPV are associated with the NVG secondary to DR group, elevated PDW and PCT are associated with the RVO group. It indicates that platelets might be an important factor in the onset and/or development of NVG.

show abstract

Relation between platelet indices and branch retinal vein occlusion in hypertensive patients

Cited by 24 publications

References 25 publications

Neutrophil/lymphocyte ratio and mean platelet volume in branch retinal vein occlusion

Neutrophil/lymphocyte ratio and mean platelet volume in branch retinal vein occlusion

Mean platelet volume in patients with retinopathy of prematurity

Role of Platelet Parameters on Neovascular Glaucoma: A Retrospective Case-Control Study in China

Contact Info

Product

Resources

About