Relation Between Schistosome Past Infection and Metabolic Syndrome

Mohamed, Sabah M. A; Saber, Taha; Taha, Afaf A; Roshdy, Hisham Samir; Shahien, Noha E.

doi:10.21608/jesp.2017.78014

Cited by 6 publications

(27 citation statements)

References 21 publications

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“…Furthermore, the greatest beneficial impact was reported in people with active infections of S. mansoni (51) presented as the largest decrease in fasting blood glucose levels. In contrast, past infection with either S. japonicum (45) or Schistosoma spp (52,53). had only a modest effect.…”

Section: Meta-analysis Of Selected Studies Association Between Parasite Infection and Fasting Blood Glucosementioning

confidence: 80%

“…Pooled data from the three studies that compared the prevalence of T2D in infected vs. non-infected populations (49,52,53) demonstrated no difference in the prevalence of T2D (Figure 5A, OR 1.03, 95% CI 0.34, 3.09; I 2 = 96%). However, sub-group analysis demonstrated that the prevalence of T2D was 46% lower among those infected with Schistosoma spp.…”

Section: Prevalence Of Type 2 Diabetes In Infected and Non-infected Populationsmentioning

confidence: 97%

“…Of the fourteen studies assessed, nine reported that infection with a parasitic worm had protective effects on diabetes-related parameters (26,(44)(45)(46)(47)(50)(51)(52)(53), however three studies (48,49,55) reported a positive association between specific infections and T2D diagnosis, and two studies (54,56) reported no association. Individual glucose homeostasis related outcomes are summarized in Supplementary Table 4.…”

Section: Study Findingsmentioning

confidence: 97%

“…For glycated hemoglobin (HbA1c), the studies included in this review used the DCCT (%) unit, where ≥6.5% was considered abnormal/diabetic. The MetS was characterized by central obesity and any two (45,53) or three (52) of the following criteria defined by the International Diabetes Federation (2): (1) BP≥ 130/85mmHg or taking antihypertensive drugs; (2) TG≥150 mg/dl; (3) HDL-C <40 mg/dl in men, < 50 mg/dl in women; (4) FBG ≥100 mg/dl or taking hypoglycemic medications.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The only studies that examined the prevalence of the metabolic syndrome (MetS) were conducted in populations that had been previously infected with Schistosome parasites (45,52,53). Analyzing the pooled data from these, demonstrated that the prevalence of MetS was 56% lower among infected populations (Figure 4, OR 0.44, 95% CI 0.29, 0.67; I 2 = 84%).…”

Section: Association Between Parasite Infection and The Prevalence Of The Metsmentioning

confidence: 99%

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The Impact of Helminth Infection on the Incidence of Metabolic Syndrome: A Systematic Review and Meta-Analysis

et al. 2021

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BackgroundThere are a growing number of publications that report an absence of inflammatory based disease among populations that are endemic to parasitic worms (helminths) demonstrating the ability of these parasites to potentially regulate human immune responses. The aim of this systematic review and meta-analysis was to determine the impact of helminth infection on metabolic outcomes in human populations.MethodsUsing PRISMA guidelines, six databases were searched for studies published up to August 2020. Random effects meta-analysis was performed to estimate pooled proportions with 95% confidence intervals using the Review Manager Software version 5.4.1.ResultsFourteen studies were included in the review. Fasting blood glucose was significantly lower in persons with infection (MD -0.22, 95% CI -0.40- -0.04, P=0.02), HbA1c levels were lower, although not significantly, and prevalence of the metabolic syndrome (P=0.001) and type 2 diabetes was lower (OR 1.03, 95% CI 0.34-3.09, P<0.0001). Infection was negatively associated with type 2 diabetes when comparing person with diabetes to the group without diabetes (OR 0.44, 95% CI 0.29-0.67, P=0.0001).ConclusionsWhile infection with helminths was generally associated with improved metabolic function, there were notable differences in efficacy between parasite species. Based on the data assessed, live infection with S. mansoni resulted in the most significant positive changes to metabolic outcomes.Systematic Review RegistrationWebsite: PROSPERO Identified: CRD42021227619.

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Section: Meta-analysis Of Selected Studies Association Between Parasite Infection and Fasting Blood Glucosementioning

confidence: 80%

Section: Prevalence Of Type 2 Diabetes In Infected and Non-infected Populationsmentioning

confidence: 97%

Section: Study Findingsmentioning

confidence: 97%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Association Between Parasite Infection and The Prevalence Of The Metsmentioning

confidence: 99%

See 3 more Smart Citations

The Impact of Helminth Infection on the Incidence of Metabolic Syndrome: A Systematic Review and Meta-Analysis

et al. 2021

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Regulation of host metabolic health by parasitic helminths

Sikder,

Pierce,

Sarkar

et al. 2024

Trends in Parasitology

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Effect of experimental hookworm infection on insulin resistance in people at risk of type 2 diabetes

Pierce¹,

McDonald²,

Merone³

et al. 2023

Nat Commun

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The reduced prevalence of insulin resistance and type 2 diabetes in countries with endemic parasitic worm infections suggests a protective role for worms against metabolic disorders, however clinical evidence has been non-existent. This 2-year randomised, double-blinded clinical trial in Australia of hookworm infection in 40 male and female adults at risk of type 2 diabetes assessed the safety and potential metabolic benefits of treatment with either 20 (n = 14) or 40 (n = 13) Necator americanus larvae (L3) or Placebo (n = 13) (Registration ACTRN12617000818336). Primary outcome was safety defined by adverse events and completion rate. Homoeostatic model assessment of insulin resistance, fasting blood glucose and body mass were key secondary outcomes. Adverse events were more frequent in hookworm-treated participants, where 44% experienced expected gastrointestinal symptoms, but completion rates were comparable to Placebo. Fasting glucose and insulin resistance were lowered in both hookworm-treated groups at 1 year, and body mass was reduced after L3-20 treatment at 2 years. This study suggests hookworm infection is safe in people at risk of type 2 diabetes and associated with improved insulin resistance, warranting further exploration of the benefits of hookworms on metabolic health.

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Relation Between Schistosome Past Infection and Metabolic Syndrome

Cited by 6 publications

References 21 publications

The Impact of Helminth Infection on the Incidence of Metabolic Syndrome: A Systematic Review and Meta-Analysis

The Impact of Helminth Infection on the Incidence of Metabolic Syndrome: A Systematic Review and Meta-Analysis

Regulation of host metabolic health by parasitic helminths

Effect of experimental hookworm infection on insulin resistance in people at risk of type 2 diabetes

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