Relation between umbilical cord blood pH, base deficit, lactate, 5‐minute Apgar score and development of hypoxic ischemic encephalopathy

Wiberg, Nana; Källén, Karin; Herbst, Andreas; Olofsson, Per

doi:10.3109/00016349.2010.513426

Cited by 82 publications

(74 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Prediction of HIE The neurological outcome was HIE using the Sarnat and Sarnat criteria 59 in three studies 36,37,58 and a combined neurological abnormality which included HIE in one study. 35 HIE was considered the common threshold outcome in these studies.…”

Section: Neonatal Outcomesmentioning

confidence: 99%

“…Alternatively, lactate has repeatedly been shown to correlate with umbilical cord pH and to have reasonable accuracy in predicting poor neonatal outcome. [28][29][30][31][32][33][34][35][36][37][38][39] Moreover, it can be measured using a hand-held meter with as little as 5 ll of blood. 30,40 This review aims to synthesise evidence on the diagnostic test accuracy of umbilical cord lactate in measuring acidosis and predicting poor neonatal outcome by comparing umbilical cord lactate with other assessments of acidosis in the immediate newborn and by assessing the ability of umbilical cord lactate to predict neonatal outcomes.…”

Section: Introductionmentioning

confidence: 99%

“…lactate/pyruvate ratio, 58 the need for neonatal resuscitation, 27 and umbilical artery pH 37 ) to predict neonatal risk. As our objective was to look at the ability of lactate to classify neonatal outcome, we extracted only data on the role of umbilical cord lactate as an isolated marker.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Umbilical lactate as a measure of acidosis and predictor of neonatal risk: a systematic review

Allanson

Waqar

White

et al. 2016

BJOG

View full text Add to dashboard Cite

Background Umbilical cord lactate is one approach to measuring acidosis and intrapartum hypoxia, knowledge of which may be helpful for clinicians involved in the care of women and newborns.Objective To synthesise the evidence on accuracy of umbilical cord lactate in measuring acidosis and predicting poor neonatal outcome.Search strategy Studies published and unpublished between 1990 and 2014 from PubMed/Medline, EMBASE, Cochrane Central Register of Controlled Trials, and clinicaltrials.gov were assessed.Selection criteria Cross-sectional and randomised studies that assessed fetal acidosis (using lactate as the index test) with or without an assessment of neonatal outcome.Data collection and analysis Correlations between index and reference test(s) were recorded, as were the raw data to classify the predictive ability of umbilical lactate for neonatal outcomes. Metaanalysis of correlation was performed. We plotted estimates of the studies' observed sensitivities and specificities on Forest plots with 95% confidence intervals (CI). Where possible, we combined data using meta-analysis, applying the hierarchical summary receiver operating characteristics model and a bivariate model.Main results Twelve studies were included. Umbilical lactate correlated with pH [pooled effect size (ES) À0.650; 95% CI À0.663 to À0.637, P < 0.001], base excess (ES À0.710; 95% CI À0.721 to À0.699, P < 0.001), and Apgar scores at 5 minutes (ES 0.300; 95% 0.193-0.407, P < 0.001). Umbilical lactate had pooled sensitivity and specificity for predicting neonatal neurological outcome including hypoxic ischaemic encephalopathy of 69.7% (95% CI 23.8-94.4%) and 93% (95% CI 86.8-96.3%).Authors' conclusion Umbilical cord lactate is a clinically applicable, inexpensive and effective way to measure acidosis and is a tool that may be used in the assessment of neonatal outcome.

show abstract

Section: Neonatal Outcomesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Umbilical lactate as a measure of acidosis and predictor of neonatal risk: a systematic review

Allanson

Waqar

White

et al. 2016

BJOG

View full text Add to dashboard Cite

show abstract

“…However, there is already an association with adverse short-term newborn outcome when pH values are below 7.05 and BD ecf values are above 10 mmol/L [7]. Alternatively, umbilical artery blood lactate concentration may be used to quantify metabolic acidosis, and values exceeding 10 mmol/L have been strongly associated with adverse short-term newborn outcome [8]. However, analyzing devices are often calibrated differently or measure lactate concentrations in different blood compartments, therefore reference values may vary according to the device [9].…”

Section: Contents Lists Available At Sciencedirectmentioning

confidence: 99%

FIGO consensus guidelines on intrapartum fetal monitoring: Physiology of fetal oxygenation and the main goals of intrapartum fetal monitoring

Ayres-de-Campos

Arulkumaran

2015

Intl J Gynecology & Obste

106

102

View full text Add to dashboard Cite

“…o Clinical features including blood pH, base deficit and Apgar score are also associated with outcome after HIE [245]. It would be useful to explore these additional features along with EEG features.…”

Section: Limitations Of the Study And Proposed Recommendationsmentioning

confidence: 99%

Design and optimisation of time-frequency analysis for multichannel neonatal EEG background features in term neonates with hypoxic ischaemic encephalopathy: characterisation, classification and neurodevelopmental outcome prediction

Awal¹

View full text Add to dashboard Cite

Neonatal Hypoxic Ischaemic Encephalopathy (HIE) is a major cause of morbidity and mortality in newborns throughout the world with an incidence of 1-8/1000 newborns in developed countries and up to 26/1000 newborns in developing countries. It causes one million neonatal deaths globally per year. Electroencephalography (EEG) is a useful method for assessment of brain activity in newborns with HIE. EEG performs well in the early diagnosis and classification of HIE severity and in predicting neurodevelopmental outcome. A normal EEG is highly predictive of a normal outcome and various abnormal EEG features are associated with neurological abnormalities or death.A systematic review and meta-analysis of the literature was undertaken to determine which specific background features of the EEG best predict outcome (Aim 1). Automatic detection and classification

show abstract

Relation between umbilical cord blood pH, base deficit, lactate, 5‐minute Apgar score and development of hypoxic ischemic encephalopathy

Cited by 82 publications

References 27 publications

Umbilical lactate as a measure of acidosis and predictor of neonatal risk: a systematic review

Umbilical lactate as a measure of acidosis and predictor of neonatal risk: a systematic review

FIGO consensus guidelines on intrapartum fetal monitoring: Physiology of fetal oxygenation and the main goals of intrapartum fetal monitoring

Design and optimisation of time-frequency analysis for multichannel neonatal EEG background features in term neonates with hypoxic ischaemic encephalopathy: characterisation, classification and neurodevelopmental outcome prediction

Contact Info

Product

Resources

About