Relation of a common variant of the adiponectin gene to serum adiponectin concentration and metabolic traits in an aged Japanese population

Abstract

Adiponectin is an adipocyte-derived protein that is down-regulated in obesity-linked disorders. Variants of the adiponectin gene (ADIPOQ) have been shown to affect adiponectin level. We have now examined the relation of polymorphisms of ADIPOQ to adiponectin concentration and to metabolic disorders in the Kita-Nagoya Genomic Epidemiology study, a population-based study of elderly Japanese. The genomic region including ADIPOQ was genotyped for 30 single nucleotide polymorphisms in 500 subjects of a screening population with the use of a fluorescence-or colorimetry-based allele-specific DNA primer-probe assay system. Four polymorphisms were then selected for genotyping in an additional 2797 subjects. Serum adiponectin level was negatively associated with metabolic abnormalities after adjustment for age and sex. The minor alleles of the rs1656930, Ile164Thr, and rs9882205 polymorphisms were associated with a low serum adiponectin level. Whereas the minor alleles of rs1656930 and rs9882205 were common (minor allele frequency of 6.2 and 38.5%, respectively), that of Ile164Thr was rare (0.9%). The minor allele of rs1656930 was positively associated with systolic blood pressure and the prevalence of hypertension. The association of rs1656930 with adiponectin level was replicated in an independent population. A subject with the 164Thr/Thr genotype had an extremely low serum adiponectin level (0.6 lg/ml) and the phenotype of metabolic syndrome. Our results suggest that a common variant of ADIPOQ, the minor allele of rs1656930, is associated with hypoadiponectinemia and hypertension. Screening for a common genetic background underlying low adiponectin levels might provide important information for assessment and management of metabolic disorders.

Population-specific coding variant underlies genome-wide association with adiponectin level

“…Nelson et al, manuscript in preparation). A different ADIPOQ missense variant (I164T) with low frequency in Japanese (MAF ¼ 0.009) has been shown to be associated with lower adiponectin levels (12), consistent with biochemical evidence that the I164T-containing adiponectin does not form trimers or high-molecular-weight multimers and impairs secretion from the adipocyte (17). However, we did not observe I164T or any other of seven known missense variants among the CLHNS samples.…”

ADIPOQ and ADIPOR2 gene polymorphisms: association with overweight/obesity in Mexican children

“…Regarding links between rs266729 and MetS, early studies reported varying results. 27,28 The rs182052 was associated with an increased risk of the prevalence of obesity in adult Korean women, but there were no significant interactions observed between the genotype of ADIPOQ rs182052 and dietary intake on BMI and body fat mass. These findings suggest that the obesity-related variables may be more dominantly affected by the genotype of ADIPOQ rs182052 than dietary intake in middle-aged Korean women.…”

ADIPOQ gene is linked to emotional eating behaviour in young Nigerian adults independent of psychological traits

“…In addition, our study observed relationship between psychological traits and EB that failed to reach statistical significance in the adjusted model. Though adiponectin gene is a known predictor of adiponectin concentrations in several populations (Hivert et al 2008;Cohen et al 2011;Tanimura et al 2011; de Luis et al 2016), we have no serum adiponectin levels available in the present study to confirm this in the young Nigerian population. Further studies are thus warranted to shed more light on the complexity of our results.…”