Relation of anatomy with function following the surgical treatment of idiopathic epiretinal membrane: a multicenter retrospective study

Özdek, Şengül; Zeydanlı, Ece Özdemir; Karabaş, Levent; Teke, Mehmet Yasin; Yılmaz, Gürsel; Çıtırık, Mehmet; Koçak, Nilüfer; Durukan, Hakan

doi:10.1007/s00417-020-05002-1

“…The EZ defect was considered to be the extent with the loss of the hyperreflective signal that characterizes the layer at the horizontal one passing through the fovea [ 17 ]. Previous reports have demonstrated a relationship between vision loss associated with ERM and disruption of the EZ and outer photoreceptor segments [ 9 , 18 ]. Disruption of the EZ has been widely recognized to be related with visual prognosis in various macular diseases, such as macular holes and edema [ 19 – 21 ].…”

Section: Methodsmentioning

confidence: 99%

Novel Optical Coherence Tomography Parameters as Prognostic Factors for Stage 3 Epiretinal Membranes

Park

¹

,

Hong

²

,

Roh

³

2020

Journal of Ophthalmology

View full text Add to dashboard Cite

Purpose. We aimed to describe the visual prognosis of eyes with ectopic inner foveal layers (EIFLs) after epiretinal membrane (ERM) surgery. Methods. This retrospective study enrolled patients diagnosed with stage 3 ERM based on the EIFL staging scheme who underwent ERM surgery with a minimum follow-up period of 12 months. Central foveal thickness (CFT), EIFL thickness, and the length of the ellipsoid zone defect were evaluated at baseline and at 1 month, 6 months, and 12 months after surgery based on pre- and postoperative swept-source optical coherence tomography (OCT) images. The association of EIFL thickness and other OCT parameters with pre- and postoperative best-corrected visual acuity (BCVA) was analyzed. Results. Sixty-nine eyes with stage 3 ERMs were analyzed. Preoperative BCVA was correlated with preoperative CFT (r = 0.517, p < 0.001 ) and preoperative EIFL thickness (r = 0.652, p < 0.001 ). At 12 months, postoperative BCVA was correlated negatively with preoperative CFT (r = 0.470, p = 0.016 ) and preoperative EIFL thickness (r = 0.582, p = 0.004 ). The improvement in BCVA was not associated with postoperative reduction in CFT p = 0.06 , although it was significantly associated with postoperative reduction in EIFL thickness (r = 0.635, p = 0.007 ). Conclusions. EIFL thickness should be considered a negative prognostic factor for postoperative anatomical and functional recovery in patients with stage 3 ERMs.

show abstract

“…Specifically, the transdifferentiation of various precursor cells into myofibroblasts and the massive production of extracellular matrix proteins containing extracellular fibrils results in fibrous contraction and distortion of the normal tissue structure ( 4 ). Retinal thickening, disorganization, and altered foveal morphology can be caused by the vertical traction and horizontal tangential forces of iERM ( 11 , 27 – 29 ). The area and depth of iERM traction were correlated with the foveal alteration and BCVA ( 30 ).…”

Section: Discussionmentioning

confidence: 99%

“…There has been increasing interest in central macular thickness (CMT) and ectopic inner foveal layer (EIFL), which primarily react to retinal alterations caused by vertical iERM traction (6,(8)(9)(10)(11). However, iERM contraction or shrinkage can cause foveal displacement.…”

Section: Introductionmentioning

confidence: 99%

Total and horizontal distances of the foveal stereotaxic displacement can be prognostic indicators for patients with idiopathic epiretinal membrane

Zhang

¹

,

Mao²,

Lao³

et al. 2023

Front. Med.

0

View full text Add to dashboard Cite

IntroductionThis study aimed to examine the foveal stereo deviations in the different ectopic inner foveal layer (EIFL) stages of idiopathic epiretinal membrane (iERM) and assess its predictive utility for the baseline and postoperative best-corrected visual acuity (BCVA).MethodsBased on the calculational combination of foveal displacements in the horizontal and vertical axial optical coherence tomography (OCT) images, the foveal stereotaxic displacement was estimated through the total distance (TD, the distance from the foveal bottom to the inner edge of displaced central foveal) and horizontal distance (HD, projection of the TD in the retinal plane). The preoperative TD, HD, and other OCT- and OCT angiography (OCTA)-related indicators were obtained. The correlations between structural parameters and baseline and postoperative BCVA were evaluated through correlation and multiple linear regression analyses.ResultsIn patients with advanced EIFL stage, there was a significant increase in the HD, TD, baseline log of the minimum angle of resolution unit for BCVA, central macular thickness (CMT), acircularity index, and incidence of microcystic macular edema (MME; p < 0.05). Further, they showed a decreased foveal avascular zone (FAZ) area and perimeter (p < 0.001). HD, TD, CMT, MME, FAZ area, and FAZ perimeter were significantly correlated with the baseline and postoperative BCVA (p < 0.05). TD had the highest correlation indexic and was an individual predictor of the baseline and postoperative BCVA. Moreover, FD-300 and MME were individual predictors of postoperative BCVA.DiscussionStereoscopic foveal deviations significantly correlated with the baseline and postoperative visual acuity. TD may be used as an independent prognostic factor for BCVA.

show abstract

“…In 2017, Ozdemir and Karacorlu reported a case with FH in an eye with ERM [ 15 ]. A multicentre, retrospective study by Ozdek et al and a retrospective case series by Ozkaya et al analysed the surgical outcome of the eyes with iERM and among them FH [ 12 , 13 ]. The incidence of FH were reported as 20.1% in 634 eyes that underwent a macular surgery for iERM [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical and morphological characteristics of patients with idiopathic epiretinal membrane with foveal herniation

Uzel

¹

,

Gelişken

²

,

Konrad

³

et al. 2022

Eye

1

0

View full text Add to dashboard Cite

Purpose To analyse the clinical and morphological characteristics of eyes with idiopathic epiretinal membrane (iERM) and foveal herniation (FH). Methods Clinical findings and OCT features of patients with iERM and FH were retrospectively analysed. Primary outcome were changes of the best-corrected-visual-acuity (BCVA) and OCT features from baseline to the last visit. FH patients were divided into two groups based on herniated layers: ganglion cell complex (GCC)-group and sub-GCC-group. Surgical outcome was also assessed. Results In this study, 3882 patients with iERM were screened, of whom 51 (1.3%) were identified with FH. The GCC-group (n = 16) had a better baseline BCVA and thinner central foveal thickness (CFT) in comparison to the sub-GCC-group (n = 35) but without statistical significance (p = 0.330, p = 0.417, respectively). The postoperative BCVA-improvement was similar between the two groups (p = 0.280). Fibrillary surface changes were detected in 42/51 (82.3%) patients, significantly more often in the sub-GCC group (p = 0.020). The baseline BCVA was a predictive factor for the postoperative vision change. Conclusion FH presents with a unique macular morphology in eyes with iERM. Affected eyes experience varying visual disturbances based on the involvement of the inner retinal layers in the foveal herniation. Macular surgery is successful in restoring vision, even though foveal morphology does not fully recover.

show abstract

Relation of anatomy with function following the surgical treatment of idiopathic epiretinal membrane: a multicenter retrospective study

Cited by 12 publications

References 38 publications

Novel Optical Coherence Tomography Parameters as Prognostic Factors for Stage 3 Epiretinal Membranes

Novel Optical Coherence Tomography Parameters as Prognostic Factors for Stage 3 Epiretinal Membranes

Total and horizontal distances of the foveal stereotaxic displacement can be prognostic indicators for patients with idiopathic epiretinal membrane

Clinical and morphological characteristics of patients with idiopathic epiretinal membrane with foveal herniation

Contact Info

Product

Resources

About