Relation of angiographically defined coronary artery disease to plasma lipoprotein subfractions and apolipoproteins.

Miller, N. E.; Hammett, F.; Saltissi, S; Rao, Suresh Ranga; Zeller, H.; Coltart, J; Lewis, Basil S.

doi:10.1136/bmj.282.6278.1741

Cited by 468 publications

(113 citation statements)

References 21 publications

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“…On the basis of their density, HDLs are currently divided into two main subclasses, HDL 2 and HDL 3 (Eisenberg, 1984) and the alcohol induced increase in HDL-C has been shown to be mainly due to the increase of the HDL 3 subfraction (Haskel et al, 1984;Va Èlima Èki et al, 1991;Williams et al, 1985) which is believed to be less antiatherogenic than HDL 2 (Miller et al, 1981).…”

Section: Introductionmentioning

confidence: 99%

Association of alcohol consumption with HDL subpopulations defined by apolipoprotein A-I and apolipoprotein A-II content

Branchi

Rovellini

Tomella³

et al. 1997

Eur J Clin Nutr

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Section: Introductionmentioning

confidence: 99%

Association of alcohol consumption with HDL subpopulations defined by apolipoprotein A-I and apolipoprotein A-II content

Branchi

Rovellini

Tomella³

et al. 1997

Eur J Clin Nutr

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“…cott et al, 1978 31 Anderson et al, 1978 32 Wieland et al, 1980" Zampogna et al, 1980 54 Holmes et al, 19815 ' Miller et al, 1981 56 Kukita et al, 1982 57 Reardon et al, 1985 58 Aro et al, 1986 3 Ellipses indicate data not available.…”

Section: Jenkins Et Al 19785°smentioning

confidence: 99%

Plasma triglyceride and coronary heart disease.

Austin

1991

Arterioscler Thromb

599

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Although the literature on epidemiological associations between plasma triglyceride and CHD is not completely consistent, trends do emerge from the studies described here. First, the majority of observational studies demonstrate a significant univariate relation, although the results of case-control and cross-sectional studies are more uniform than those from prospective study designs. In many but not all studies, triglyceride remains a significant predictor of CHD in multivariate statistical analyses after controlling for TC or LDL-C. Perhaps the least consistent result is that the triglyceride association does not persist in some analyses controlling for HDL-C, while in other studies, the association remains significant. Although most studies have been conducted in men, the studies providing data on women, normocholesterolemic subjects, and diabetic subjects have generally found triglyceride to be, at the very least, a univariate risk factor. The results of intervention trials differ considerably, but no such study to date has been specifically designed to evaluate triglyceride-lowering effects on primary prevention of CHD. Important statistical properties must be taken into consideration in evaluating triglyceride as a risk factor for CHD. The large variability of triglyceride measurements and the correlation of triglyceride values with other lipid measures appears to result in the underestimation of the association between triglyceride and disease in multivariate analyses. Finally, individual genetic susceptibility may play an important role in the relation between plasma triglyceride levels and CHD. For example, risk of CHD clearly varies among the well-established familial forms of hypertriglyceridemia. A predominance of small, dense, LDL particles (LDL subclass pattern B) also appears to be a genetic trait associated with both increased risk of MI and increases in plasma triglyceride levels.

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“…19 Thus, a low HDLj concentration may reflect an inefficient lipolytic process, 7 perhaps increasing the intravascular residence time of certain atherogenic intermediates. 5 On the other hand, a reduced HDLj level might be partly due to increased catabolism of HDLj via hepatic lipase. 20 Female diabetics with Ml had higher levels of total, LDL, and VLDL triglycerides than female diabetics without Ml or without CHD; however, such a difference was not observed in males.…”

Section: Discussionmentioning

confidence: 99%

Association of low HDL and HDL2 cholesterol with coronary heart disease in noninsulin-dependent diabetics.

Laakso¹,

Voutilainen²,

Pyörälà³

et al. 1985

Arteriosclerosis

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Lipids and lipoproteins were measured in 139 men and 145 women who were noninsulin-dependent diabetics (NIDDs) aged 45 to 64 years. Of these, 27 men and 16 women had had a previous definite myocardial infarction (Ml). The NIDDs with Ml (Ml+ ) showed lower values of HDL and HDL 2 cholesterol concentrations than NIDDs without previous Ml (Ml-) or NIDDS without any symptoms or electrocardiographic signs of coronary heart disease (CHD-). The inverse relationship between HDL, HDL 2 , and CHD was evident in both sexes, but it was particularly strong among male NIDDs. The difference in HDL and HDL 2 cholesterol concentrations between the MI + and Ml -groups or between the Ml + and CHD -groups persisted after adjustment by analysis of covariance for the effect of physical activity, alcohol intake, obesity, duration of diabetes, and glycemic control. It is concluded that in a cross-sectional study, even among NIDDs with generally low HDL and HDL 2 cholesterol concentrations, the presence of CHD is associated with a further depression of HDL and HDL 2 cholesterol levels. Prospective studies are needed, however, to confirm that the association is predictive and not a consequence of CHD. (Arteriosclerosis 5:653-658, November/December 1985) L ow concentration of serum high density lipoprotein (HDL) cholesterol has been shown to be strongly associated with an increased risk of coronary heart disease (CHD) in nondiabetic populations. 1 " 6 Among diabetics, patients with noninsulindependent diabetes (NIDDs) have a lower level of HDL cholesterol than corresponding nondiabetic control subjects. 7 At present, it is unclear whether the presence of CHD is associated with a further lowering of HDL cholesterol in this diabetic population which has a generally low level of HDL cholesterol. Therefore, our study compared lipid and lipoprotein levels in NIDDs with and without CHD. Methods PatientsAll diabetic patients in Finland needing drug therapy are provided with it free of charge accord- Received March 6, 1985; revision accepted June 26, 1985. ing to the Sickness Insurance Act. The Social Insurance Institution maintains a central register of diabetics who receive drug reimbursement. On the basis of this register, we identified 791 diabetic patients aged 45 to 64 years who had been diagnosed as diabetic after the age of 30 years and who lived near Kuopio University Central Hospital, East Finland. The main purpose was to obtain a population for a study that would compare the prevalence of CHD and its risk factors in middleaged NIDDs living in East and West Finland. 8 Among the total population of 791 diabetics, we selected 284 persons (139 men, 145 women) for the present study. The criteria were as follows:1. Diet-treated diabetics. There were 104 eligible diabetics (57 men, 47 women) of whom 88 participated (48 men, 40 women; participation rate, 85%). These patients' diabetes medication had been stopped at least 3 months before the study.2. Diabetics treated with oral hypoglycemic drugs. A random sample of 173 diabetics (90 me...

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Relation of angiographically defined coronary artery disease to plasma lipoprotein subfractions and apolipoproteins.

Cited by 468 publications

References 21 publications

Association of alcohol consumption with HDL subpopulations defined by apolipoprotein A-I and apolipoprotein A-II content

Association of alcohol consumption with HDL subpopulations defined by apolipoprotein A-I and apolipoprotein A-II content

Plasma triglyceride and coronary heart disease.

Association of low HDL and HDL2 cholesterol with coronary heart disease in noninsulin-dependent diabetics.

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