Relation of Increasing QRS Duration Over Time and Cardiovascular Events in Outpatients With Heart Failure

Alfraidi, Hassan; Seifer, Colette; Hiebert, Brett; Torbiak, Lindsay; Zieroth, Shelley; McIntyre, William F.

doi:10.1016/j.amjcard.2019.09.018

Cited by 9 publications

(4 citation statements)

References 16 publications

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“…QRS duration represents ventricular depolarization and prolongation in QRS duration was found to be associated with an increased risk of arrhythmia and cardiovascular events 23 . In a retrospective multicenter study, Hathaway et al reported that prolonged QRS duration has prognostic significance in predicting mortality in patients with myocardial infarction 24 .…”

Section: Discussionmentioning

confidence: 99%

“…Lastly, the fibrogenic mechanism negatively affects cardiac functions and heightens the risk of arrhythmia since the cardiac conduction system is also affected by fibrosis [22]. QRS duration represents ventricular depolarization and prolongation in QRS duration was found to be associated with an increased risk of arrhythmia and cardiovascular events [23]. In a retrospective multicenter study, Hathaway et al reported that prolonged QRS duration has prognostic significance in predicting mortality in patients with myocardial infarction [24].…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of QRS duration and presence of fragmented QRS in patients with inflammatory bowel disease

Güven,

Candemir,

Kayacetin

2024

Int. J. Med. Sci.

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Background: Inflammatory Bowel Disease (IBD) is mostly characterized by gastrointestinal tract involvement, however can also be accompanied with cardiac manifestations. QRS prolongation and the presence of QRS fragmentation (fQRS) have been previously evaluated in many chronic inflammatory diseases, as an independent predictor of cardiac events. In this study, we aimed to evaluate the QRS duration and fQRS in patients with IBD. Methods: The presented study was designed as a single-center retrospective cohort study. The study population consisted of 217 patients with IBD and 195 healthy controls. QRS duration and presence of fQRS were evaluated using a 12-lead electrocardiogram. These parameters were compared between groups. Results: QRS duration was demonstrated to be higher in the IBD group compared to the control group (92 (86-98) vs. 82 (75-90), p<0.001). The presence of fQRS was significantly higher in the IBD group (n=101 (47%) vs n=59 (30%), p=0.006). In addition, a positive correlation was demonstrated between QRS duration and disease duration (Spearman's Rho= 0.4, p<0.001). Notably, disease and QRS duration were significantly higher in the fQRS (+) group (102 (56.5-154) vs. 55 (24.3-118.3), <0.001; 94 (86-100) vs. 92 (84-96), 0.016; respectively). Conclusion: Our results demonstrated that QRS prolongation and the presence of fQRS (+) were more common in IBD patients, and associated with longer disease duration. These findings may indicate subclinical cardiac involvement in IBD. Therefore, IBD patients, especially those with long-standing disease, should be followed more closely in terms of cardiac manifestations.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluation of QRS duration and presence of fragmented QRS in patients with inflammatory bowel disease

Güven,

Candemir,

Kayacetin

2024

Int. J. Med. Sci.

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“…6) Furthermore, Hassan, et al revealed that mortality and heart failure hospitalization rates increased as the QRS duration was wider in patients with heart failure. 7) The aim of CRT is to obtain electrical resynchronization, and QRS narrowing is one of the most important outcomes. A metaanalysis of CRT studies has shown a significant association between QRS narrowing during BiV-CRT and CRT response, and CRT responders had greater QRS narrowing compared with non-responders.…”

Section: Discussionmentioning

confidence: 99%

Conduction System Pacing Upgrade in Chronic Heart Failure with Severe Left Ventricular Dysfunction and Chronic Atrial Fibrillation

et al. 2023

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Cardiac resynchronization therapy (CRT) is a standard treatment for patients with severe congestive heart failure. However, one-third of patients receiving CRT are non-responders. Conduction system pacing (CSP), including His-bundle pacing (HBP) and left bundle branch area pacing (LBBAP), has become an alternative to CRT therapy. Furthermore, CRT therapy with CSP has shown to be more effective than CRT alone. When an implantable cardiac defibrillator or CRT-defibrillator is implanted with CSP, the problem of which port the HBP lead and LBBAP lead should be connected to arises. We report 2 cases of upgrading to CRT with CSP by utilizing the atrial ports for HBP and LBBAP leads. The procedure is a simple, reasonable, and effective therapy for end-stage heart failure.

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“…1 IVCD and QRS widening have generally been recognized as poor prognostic factors and require special attention from clinicians. 2,3 Given its poorer prognosis, this wide spectrum of conduction diseases deserves to be better defined to optimize patient care, but good quality data have been lacking regarding the long-term prognosis of IVCD in the population of patients referred for coronary angiograms.…”

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confidence: 99%

The Prognostic Value of Intraventricular Conduction Disturbances: A Matter of Time?

Marquis‐Gravel

Raymond-Paquin

McIntyre

2020

Canadian Journal of Cardiology

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Relation of Increasing QRS Duration Over Time and Cardiovascular Events in Outpatients With Heart Failure

Cited by 9 publications

References 16 publications

Evaluation of QRS duration and presence of fragmented QRS in patients with inflammatory bowel disease

Evaluation of QRS duration and presence of fragmented QRS in patients with inflammatory bowel disease

Conduction System Pacing Upgrade in Chronic Heart Failure with Severe Left Ventricular Dysfunction and Chronic Atrial Fibrillation

The Prognostic Value of Intraventricular Conduction Disturbances: A Matter of Time?

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