Relation of inflammation and left atrial remodeling in atrial fibrillation occurring in early phase of acute myocardial infarction

Hwang, Hye Jin; Ha, Jong Won; Joung, Boyoung; Choi, Eun Hee; Kim, Jae-Deok; Ahn, Min Soo; Lee, Moon Hyoung; Jang, Yangsoo; Chung, Namsik; Kim, Sung Soon

doi:10.1016/j.ijcard.2009.05.065

Cited by 37 publications

(22 citation statements)

References 32 publications

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“…Two studies had no data on preprocedural NT-proBNP levels. The foregoing studies were all excluded, and six observational studies [6][7][8][9]16,17] were finally included in our meta-analysis ( Figure 1). As a result, a total of 5861 patients were involved in our review: 438 in the new-onset AF group, and 5423 in the no-AF group.…”

Section: Resultsmentioning

confidence: 99%

“…We subsequently performed sensitivity analyses in order to identify the origin of this heterogeneity [12]. As shown in Figure 3, after excluding the studies by Dorje et al [16] and Hwang et al [9] the heterogeneity test showed no significant effects on the results (p ¼ 0.66; I 2 ¼ 0%), whereas the SMD in the NT-proBNP levels between the patients with and without AF was 0.42 units (95% CI 0.31-0.52), the z-score for overall effect was 7.66 (p < 0.00001).…”

Section: Resultsmentioning

confidence: 99%

“…Because this test has poor power in the event of few studies, we considered both the presence of significant heterogeneity at the 10% level of significance and values of I 2 exceeding 56% as an indicator of significant heterogeneity [14], so that a pooled effect could be calculated with a random-effects model that was used to take into account within-study and between-study variance, or otherwise, with a fixed-effects model. To explore sources of [16] Case-control study * * * * * * * 7 Hwang et al [9] Case-control study * * * * * * * 7 Parashar et al [17] Cohort study * * * * * * * * 8 Guenancia et al [8] Case-control study * * * * * * 6 Gal et al [7] Case-control study * * * * * * * * 8 *The Newcastle-Ottawa Scale criteria are listed in supplemental files. heterogeneity, we performed several sensitivity analyses.…”

Section: Methodsmentioning

confidence: 99%

“…In the past few years, several studies were performed in AF patients and non-AF controls after ACS to evaluate this association. Finally, some studies indicated positive association while others demonstrated negative results [6][7][8][9]. To better clarify the associations of NT-proBNP with new-onset AF after ACS, we conducted a comprehensive metaanalysis by collecting and analyzing previously published studies.…”

Section: Introductionmentioning

confidence: 99%

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Relation of N-terminal pro-brain natriuretic peptide and new-onset atrial fibrillation in patients with acute coronary syndrome: a systematic review and meta-analysis

Gao

Zeng

Liao

et al. 2016

Scandinavian Journal of Clinical and Laboratory Investigation

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Relation of N-terminal pro-brain natriuretic peptide and new-onset atrial fibrillation in patients with acute coronary syndrome: a systematic review and meta-analysis

Gao

Zeng

Liao

et al. 2016

Scandinavian Journal of Clinical and Laboratory Investigation

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“…[6][7][8] Editorial p. 3 Innate immune factors play important roles in most cardiac diseases. [9][10][11] As data has shown in recent research, toll-like receptors increase in either plasma or tissues as innate immune factors in ischemia heart diseases and arrhythmias diseases. [12][13][14] Notably, TLR4 could directly stimulate macrophages and induce atheroma formation, while TLR4 deficiency has been shown to have a protective effect against myocardial ischemic injury.…”

mentioning

confidence: 99%

Toll-Like Receptors 2 and 4 Predict New-Onset Atrial Fibrillation in Acute Myocardial Infarction Patients

Zhang

Shao

2018

Int. Heart J.

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SummaryMyocardial infarction (MI) can cause new-onset atrial fibrillation (AF) due to cardiac remodeling. As a recent study has shown, inflammatory factors are closely tied to cell death and survival in myocardial ischemia injury. Toll-like receptors (TLRs) have been shown to participate in the process of myocardial infarction as innate immune factors.The subjects were divided into 3 groups: healthy controls (n = 82), MI patients (n = 84), and AFMI (newonset atrial fibrillation after myocardial infarction) patients (n = 85). Peripheral blood mononuclear cell (PBMC) TLR mRNA expression was detected by rt-PCR. Western blot was used to analyze PBMC TLRs and their downstream signal protein expression. PBMCs were presented as TLR2 expression or TLR4 expression using flow cytometry.From mRNA to protein detection, PBMC TLR2 and TLR4 were significantly higher in the AFMI group than in the control group and MI group. A similar tendency was also observed in the expression of downstream signaling proteins. When further analyzed with TLR2 and TLR4 antibodies by flow cytometry, PBMC levels also appeared to be higher in AFMI patients than those in MI patients and the healthy control group.In our study, PBMC TLRs and their downstream signaling proteins were significantly higher in the acute myocardial infarction patients with new-onset atrial fibrillation compared with healthy people and acute myocardial infarction patients without new-onset atrial fibrillation. They have the potential to be novel biomarkers for new-onset atrial fibrillation after acute myocardial infarction.(Int Heart J 2018; 59: 64-70) Key words: Innate immune A s one component of the global burden of cardiac arrhythmia disease, atrial fibrillation (AF) is generally divided into valvular and non-valvular AF. Myocardial infarction (MI) is an independent risk factor for new-onset AF which occurs in 6% to 21% of acute MI patients due to post myocardial infarction remodeling. [1][2][3][4][5] Unfortunately, AF is highly associated with substantial morbidity and mortality increases after myocardial infarction. 6-8) Editorial p.3Innate immune factors play important roles in most cardiac diseases. [9][10][11] As data has shown in recent research, toll-like receptors increase in either plasma or tissues as innate immune factors in ischemia heart diseases and arrhythmias diseases. [12][13][14] Notably, TLR4 could directly stimulate macrophages and induce atheroma formation, while TLR4 deficiency has been shown to have a protective effect against myocardial ischemic injury. 15,16) Furthermore, there is some evidence for TLR4 in ventricular remodeling after acute myocardial infarction. 17,18) However, the effect of TLR2 on heart disease remains controversial. In TLR2 knock-out mice, there was no obvious difference in infarct size compared to wild type mice, although a negative effect on fibrosis in the non-infarcted area and a positive effect on left ventricular remodeling have been reported. 19,20) However, TLR2 also has been found to trigger atrial fibrillation and fa...

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Mechanisms of new-onset atrial fibrillation complicating acute coronary syndrome

Wang

Yang

Zhu

2014

Herz

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Atrial fibrillation (AF) is one of the most common arrhythmia complications of acute coronary syndrome (ACS). The incidence of new-onset AF is 2.3-37 %, and it is an important predictor of a patient's morbidity, mortality, and prolonged hospitalization. Various risk factors for the development of new-onset AF after ACS have been identified, including: old age, higher Killip class, relevant history (e.g., hypertension), and enlarged left atrium. Insights into the pathophysiological mechanisms of new-onset AF have been provided by both experimental and clinical investigations and show that new-onset AF is multifactorial, involving atrial ischemia and atrial stretch, inflammation, autonomic nervous system activity, and hormone activation. An understanding of the mechanisms underlying new-onset AF complicating ACS can provide new insight of therapeutic importance.

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Relation of inflammation and left atrial remodeling in atrial fibrillation occurring in early phase of acute myocardial infarction

Cited by 37 publications

References 32 publications

Relation of N-terminal pro-brain natriuretic peptide and new-onset atrial fibrillation in patients with acute coronary syndrome: a systematic review and meta-analysis

Relation of N-terminal pro-brain natriuretic peptide and new-onset atrial fibrillation in patients with acute coronary syndrome: a systematic review and meta-analysis

Toll-Like Receptors 2 and 4 Predict New-Onset Atrial Fibrillation in Acute Myocardial Infarction Patients

Mechanisms of new-onset atrial fibrillation complicating acute coronary syndrome

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