Relation of plasma ceramides to visceral adiposity, insulin resistance and the development of type 2 diabetes mellitus: the Dallas Heart Study

Neeland, Ian J.; Singh, Shruti; McGuire, Darren K.; Vega, Gloria Lena; Roddy, Thomas P.; Reilly, Dermot F.; Castro-Perez, José; Kozlitina, Julia; Scherer, Philipp E.

doi:10.1007/s00125-018-4720-1

Cited by 73 publications

(62 citation statements)

References 40 publications

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“…We replicated these results in another cohort, the CoLaus study [2]. Other recent cohort studies yielded similar results with ceramides, but did not report plasma dihydroceramide concentrations [3,4].…”

Section: Introductionsupporting

confidence: 79%

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Dairy consumption is associated with lower plasma dihydroceramides in women from the D.E.S.I.R. cohort

Fumeron¹,

Nicolás²,

Bastard³

et al. 2020

Diabetes & Metabolism

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Aim: In the D.E.S.I.R. cohort, a higher consumption of dairy products is associated with a lower incidence of hyperglycemia, and dihydroceramide concentrations are higher in people who progress to diabetes. Our aim here is to study relationships between dairy consumption and concentrations of dihydroceramides and ceramides. Methods: In the D.E.S.I.R. cohort, men and women aged 30-65 years, volunteers from western-central France, were included for a 9-year follow-up, with examinations every 3 years, including food frequency questionnaires. Two items concerned dairy products (cheese, other dairy products). At each examination, dihydroceramides and ceramides were determined by mass spectrometry in a subset of the cohort; we analyzed the 105 people who did not progress to diabetes, because disease per se might be a confounding factor. Results: A higher consumption of dairy products (except cheese) was associated with total plasma dihydroceramides during follow-up, but only in women (sex interaction P=0.01): dihydroceramide levels were lower in women with a high consumption as compared to the low consumers (P=0.03), and significantly increased during the follow-up (P=0.01) in low consumers only. There was also a trend for lower ceramides in women with a high intake of dairy (except cheese) (P=0.08). Cheese was associated with dihydroceramides and ceramides changes during follow-up (P=0.04 for both), but no clear trend could be seen in either the low or high consumers. Conclusion: These results show, in women, an inverse association between fresh dairy product consumption and predictive markers of type 2 diabetes, the dihydroceramides.

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Section: Introductionsupporting

confidence: 79%

“…Among the strengths are the prospective nature of the data. The size of our study may seem limited, however repeated measurements of ceramides were performed, which is not the case in larger cohort studies with only one single measurement [3,4]. We were also able to adjust for confounders such as lifestyle factors.…”

Section: Discussionmentioning

confidence: 99%

Dairy consumption is associated with lower plasma dihydroceramides in women from the D.E.S.I.R. cohort

Fumeron¹,

Nicolás²,

Bastard³

et al. 2020

Diabetes & Metabolism

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show abstract

“…Indeed, in a large multi-ethnic Dallas Heart Study, plasma short-chain saturated ceramides, such as C16:0 and C18:0 were positively linked with insulin resistance, dyslipidemia and visceral adiposity. In contrast, plasma polyunsaturated ceramides (C24:2, C30:10 and C32:11) were inversely associated with these unfavorable phenotypes [130]. These findings suggest that C16:0 and C18:0 ceramides are linked with de-regulated adiposity.…”

Section: Targeting Ceramide Biosynthesis In Adipose Tissuementioning

confidence: 83%

Ceramide and sphingosine 1-phosphate in adipose dysfunction

Fang

Pyne

2019

Progress in Lipid Research

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The increased adipose tissue mass of obese individuals enhances the risk of metabolic syndrome, type 2 diabetes and cardiovascular diseases. During pathological expansion of adipose tissue, multiple molecular controls of lipid storage, adipocyte turnover and endocrine secretion are perturbed and abnormal lipid metabolism results in a distinct lipid profile. There is a role for ceramides and sphingosine 1-phosphate (S1P) in inducing adipose dysfunction. For instance, the alteration of ceramide biosynthesis, through the deregulation of key enzymes, results in aberrant formation of ceramides (e.g. C16:0 and C18:0) which block insulin signaling and promote adipose inflammation. Furthermore, S1P can induce defective adipose tissue phenotypes by promoting chronic inflammation and inhibiting adipogenesis. These abnormal changes are discussed in the context of possible therapeutic approaches to re-establish normal adipose function and to, thereby, increase insulin sensitivity in type 2 diabetes. Such novel approaches include blockade of ceramide biosynthesis using inhibitors of sphingomyelinase or dihydroceramide desaturase and by antagonism of S1P receptors, such as S1P2.

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“…With a targetted analysis for the identification of 13 selected species, we found in almonds and pistachios a prevalence of C16:0 ceramide. A recent article (Neeland et al, 2018), reports that circulating shorter-chain saturated fatty acid ceramides (C16:0, C18:0)…”

Section: O-β-d-glucopyranosyl-(2s3r4e8z)-2-[(2r)-2-hydroxyhexadecamentioning

confidence: 99%

Bioactive phytochemicals of tree nuts. Determination of the melatonin and sphingolipid content in almonds and pistachios

Paroni

Dei

Rizzo

et al. 2019

Journal of Food Composition and Analysis

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Tree nuts are healthy foods rich in bioactive phytochemicals. Their regular, moderate consumption has been associated with a reduced risk of chronic-degenerative diseases, in the context of a healthy diet and lifestyle. This study aimed to investigate the phytochemical profile of almonds and pistachios, in order to add new elements in the complex scenario of nut chemistry. A LC-MS/MS method was developed to quantify melatonin and ceramides in almonds and pistachios. In general, pistachios were richer in melatonin (2609±3096 vs 1222±500 pg/g) and total ceramides (302±77 vs 165±21 pmol/g) than almonds. Among total ceramides fatty acyl homologs, the most represented was the C16:0 species, both for ceramides and dihydroceramides, and both in almonds (37-40%) and pistachios (51-74%). Overall, these results add a piece of information to elucidate the chemical composition of almonds and pistachios and provide a rationale for the nutraceutical potential of nuts in the Mediterranean diet.

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Relation of plasma ceramides to visceral adiposity, insulin resistance and the development of type 2 diabetes mellitus: the Dallas Heart Study

Abstract: Plasma ceramides demonstrate a biologically complex relationship with metabolic and imaging indicators of dysfunctional adiposity. The role of ceramides in a shared pathway of metabolic dysfunction linking visceral adiposity and insulin resistance requires further investigation.

Cited by 73 publications

References 40 publications

Dairy consumption is associated with lower plasma dihydroceramides in women from the D.E.S.I.R. cohort

Dairy consumption is associated with lower plasma dihydroceramides in women from the D.E.S.I.R. cohort

Ceramide and sphingosine 1-phosphate in adipose dysfunction

Bioactive phytochemicals of tree nuts. Determination of the melatonin and sphingolipid content in almonds and pistachios

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