Relation of stiffness parameter β to carotid arteriosclerosis and silent cerebral infarction in patients on chronic hemodialysis

Ogawa, Tetsuya; Shimada, Makoto; Ishida, Hideyuki; Matsuda, Nami; Fujiu, Ayuko; Ando, Yumiko; Nitta, Kosaku

doi:10.1007/s11255-009-9526-0

Cited by 26 publications

(23 citation statements)

References 33 publications

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“…The mean IMT was also significantly correlated with those variables except for BMI. Although there was a significant positive correlation between the stiffness parameter b and the mean IMT, the correlation was not strong (r = 0.33, P \ 0.0001), which is consistent with a previous report [21]. These results indicate that different mechanisms might contribute to arterial stiffness and thickness.…”

Section: Discussionsupporting

confidence: 86%

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The stiffness parameter β assessed by an ultrasonic phase-locked echo-tracking system is associated with plaque formation in the common carotid artery

et al. 2011

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Section: Discussionsupporting

confidence: 86%

“…A parameter for assessing arterial wall stiffness, the stiffness parameter b, has been developed and has been reported to be independent of blood pressure [16]. It has been used to evaluate arterial stiffness in patients with type 2 diabetes [17][18][19] and in patients with chronic renal disease [20,21].…”

Section: Introductionmentioning

confidence: 99%

The stiffness parameter β assessed by an ultrasonic phase-locked echo-tracking system is associated with plaque formation in the common carotid artery

et al. 2011

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“…All subjects underwent a brain MRI (EXCELART, Toshiba Co., Tokyo, Japan) with a superconducting magnet at a field strength of 1.5 T on proton density, T1-, and T2-weighted images were acquired in the axial planes at 10 minutes thick slices as previously described (12). Infarction was diagnosed when a focal area larger than 3 mm in diameter was observed on both T1-and T2-weighted images and was visible as a low-signal intensity area on the T1-weighted image and as a high-signal intensity area on the T2-weighted image.…”

Section: Diagnosis Of Scimentioning

confidence: 99%

Relation of Carotid Intima-Media Thickness and Silent Cerebral Infarction to Cardiovascular Events and All-Cause Mortality in Chronic Hemodialysis Patients

et al. 2012

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Objective Silent cerebral infarction (SCI) and increased carotid intima-media thickness (IMT) have been found to be associated with future stroke in the general population. We investigated whether a combination of SCI and increased IMT is a predictor of cardiovascular events and all-cause mortality in chronic hemodialysis (HD) patients. Methods We performed a retrospective cohort study of 70 HD patients who had one or more risk factors for atherosclerosis but no history of cardiovascular disease. We performed cranial magnetic resonance imaging (MRI) and measured carotid IMT at baseline, and then evaluated the risks of cardiovascular events and all-cause mortality by using Cox proportional hazards models. The Kaplan-Meier method and a log-rank test were used to compare event-free survival.Results SCI was present in 25 patients (35.7%) at baseline. During an average follow-up of 46.3±14.3 months (range: 19 to 56 months), 15 patients (21.4%) died and 16 (22.9%) experienced a new cardiovascular event. The presence of SCI in combination with increased carotid IMT at baseline was independently associated with cardiovascular events and all-cause mortality after adjustment for age, sex, duration of dialysis, and traditional vascular risk factors. Conclusion SCI, similar to carotid IMT, is an independent predictor of cardiovascular events and all-cause mortality in chronic HD patients.

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“…They concluded that recognition of this characteristic as an important predictor of mortality suggests that one goal of antihypertensive therapy in patients with PD should be to decrease elevated pulse pressure. Moreover, Ogawa et al [48] showed that arteriosclerosis assessed by stiffness parameter beta is associated with atherosclerotic changes of carotid arteries and with the presence of silent cerebral infarction in patients with HD . Haydar et al [49] found that PWV strongly correlates with total calcification scores assessed by means of EBCT, even after correction for age, dialysis therapy duration, prescribed dose of calcium-containing phosphate binders, and microinflammatory status.…”

Section: Pathogenesis Of Arterial Stiffnessmentioning

confidence: 99%

Arterial stiffness in dialysis patients: where are we now?

et al. 2009

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Patients with end-stage renal disease treated by chronic dialysis have an impressive mortality, which more than half of this mortality is attributable to cardiovascular disease. Despite stratification for sex, race, and the presence of diabetes, cardiovascular disease mortality is 10-30 times higher in dialysis patients compared to general population. In dialysis patients, both atherosclerosis (mainly affecting the intima of the arteries) and arteriosclerosis (affecting predominantly the media of large- and middle-sized arteries diffusely) are highly prominent. Arteriosclerosis characterized by reduced arterial compliance (i.e., reduced elasticity of the arteries) is due to increased fibrosis, loss of elastic fibers, and extensive vessel wall calcification. Arteriosclerosis is closely related to arterial stiffness. A generally accepted mechanistic view is that an increase in arterial stiffness causes a premature return of reflected waves in late systole, increasing central pulse pressure, thus systolic. An increased arterial stiffness can increase the risk of stroke through several mechanisms, including an increase in central pulse pressure, influencing arterial remodeling both at the site of the extracranial and intracranial arteries, increasing carotid wall thickness, and the development of stenosis and plaques, and the likelihood of plaque rupture. Very importantly, it was also suggested that arterial stiffness itself independently plays a role in exacerbating chronic kidney disease progression. This review deals briefly with the definition of arterial stiffness, methods of measuring arterial stiffness and pathophysiology of arterial stiffness, and factors related with arterial stiffness.

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Relation of stiffness parameter β to carotid arteriosclerosis and silent cerebral infarction in patients on chronic hemodialysis

Abstract: These results suggest that arteriosclerosis assessed by stiffness parameter beta is associated with atherosclerotic changes of carotid arteries and with the presence of SCI in HD patients.

Cited by 26 publications

References 33 publications

The stiffness parameter β assessed by an ultrasonic phase-locked echo-tracking system is associated with plaque formation in the common carotid artery

The stiffness parameter β assessed by an ultrasonic phase-locked echo-tracking system is associated with plaque formation in the common carotid artery

Relation of Carotid Intima-Media Thickness and Silent Cerebral Infarction to Cardiovascular Events and All-Cause Mortality in Chronic Hemodialysis Patients

Arterial stiffness in dialysis patients: where are we now?

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