Relations Between Replication and Transcription

Studying RNA–Protein Interactions of Pre-mRNA Complexes by Mass Spectrometry

“…Together, nucleic acids and proteins play a vital role in the major biological processes, such as transcription (Castro-Roa & Zenkin, 2011), DNA replication, recombination and repair (Antony et al, 2013), and RNA processing, e.g., mRNA splicing (Blencowe, 2006), localization (Lecuyer, Yoshida, & Krause, 2009), degradation (Garneau, Wilusz, & Wilusz, 2007;Tadros et al, 2007;Walser & Lipshitz, 2011), and translation (Wilhelm & Smibert, 2005). About 23% of the human genes so far functionally annotated correspond to nucleic acid-binding proteins (Ule, Jensen, Mele, & Darnell, 2005) and more than 800 RNA-binding proteins (RBPs) have been reported to be encoded by the mammalian genome (Castello et al, 2012).…”