Relations between Serum Reactive Oxygen Metabolites (ROMs) and Various Inflammatory and Metabolic Parameters in a Japanese Population

Hara, Hiroshi; Kawabe, Hiroshi; Komiya, Naoko; Saito, Ikuo

doi:10.5551/jat.e265

Cited by 46 publications

(46 citation statements)

References 33 publications

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“…Recent studies have shown the usefulness of the evaluation of oxidative stress using d-ROMs. [13][14][15][16] However, this is the first study to measure them simultaneously in a large number of subjects to evaluate oxidative stress from the viewpoint of lifestyle-related disease.…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies have also shown the positive correlation between the levels of hsCRP and d-ROMs. [14][15][16] Chronic inflammatory processes have been recognized to have a role in the pathogenesis of atherosclerosis. [22][23][24] Therefore, an increase of visceral fat tissue that promotes inflammation, as represented by hsCRP, may have a role in the pathogenesis of atherosclerosis; our result suggests the significance of measuring d-ROMs.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, simpler methods for detecting reactive oxygen species (ROS) using derivatives of reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) were developed, and reports on studies using these methods have been increasing. [10][11][12][13][14][15][16][17][18][19][20] Thus, in the present study, we measured d-ROMS and BAP as indices for the production of ROS and antioxidant potential, respectively. …”

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confidence: 99%

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Significance of measuring oxidative stress in lifestyle-related diseases from the viewpoint of correlation between d-ROMs and BAP in Japanese subjects

et al. 2011

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In recent years, oxidative stress has been postulated to be an important factor in the pathogenesis and development of lifestyle-related diseases. In this study, we investigated the association between the derivatives of reactive oxygen metabolites (d-ROMs), as an index of products of reactive oxygen species (ROS), and biological antioxidant potential (BAP), as an index of antioxidant potential. We also investigated the associations between d-ROMs or BAP and the risk factors for lifestyle-related diseases or metabolic syndrome-associated factors to evaluate their usefulness in preventive medicine. There were 442 subjects who underwent health checkup examination in our facilities. In addition to standard medical checkup items, we analyzed d-ROMs, BAP, brachial-ankle pulse wave velocity, high-sensitivity C-reactive protein level and visceral fat area (VFA) visualized on a computed tomography scan. The mean d-ROM value in females was significantly higher than that in males. There was a positive correlation between the d-ROM and VFA levels. On correlation analysis, there was a negative correlation between the d-ROM and creatinine levels. As factors that influence d-ROMs, the level of VFA was selected, suggesting the significance of oxidative stress measurement with d-ROMs. In addition, there was a positive correlation between d-ROMs and BAP values. Further research is required to resolve whether increased production of ROS or the antioxidant potential that can compensate for such an increase of ROS is more important in vivo. INTRODUCTIONOxidative stress may be involved in various disorders and pathogeneses, especially in lifestyle-related diseases, and it causes the progression and acceleration of atherosclerosis. 1-3 Biomarkers of oxidative stress, such as serum malondialdehyde level measured as thiobarbituric acid-reactive substances, oxidized low-density lipoprotein, oxidation injury of DNA, 8-hydroxydeoxyguanosine and urinary excretion of 8-iso-prostaglandin-F2a, are generally measured in laboratories. [4][5][6][7] On the other hand, as indices of antioxidant potential, intracellular levels of superoxide dismutase and glutathione peroxidase have mainly been measured. [8][9] However, these assay methods are complex and are not suitable for analysis of a large number of subjects. Recently, simpler methods for detecting reactive oxygen species (ROS) using derivatives of reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) were developed, and reports on studies using these methods have been increasing. [10][11][12][13][14][15][16][17][18][19][20] Thus, in the present study, we measured d-ROMS and BAP as indices for the production of ROS and antioxidant potential, respectively.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Significance of measuring oxidative stress in lifestyle-related diseases from the viewpoint of correlation between d-ROMs and BAP in Japanese subjects

et al. 2011

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“…Thus, selection for high growth potential might have impaired the ability to adapt to oxidative stress and/or accelerated ROS production through higher metabolic rate. Serum d-ROMs are also associated with inflammation (Hirose et al, 2009) and to physical activity (Bloomer and Fisher-Wellman, 2008) in humans. In our study, the differences between the two genotypes are unlikely to result from differences in inflammatory status, as the two breeds did not differ in their acute-phase proteins levels (see below paragraph).…”

Section: Discussionmentioning

confidence: 99%

Health and immune traits of Basque and Large White pigs housed in a conventional or enriched environment

Merlot

Vincent

Thomas

et al. 2012

Animal

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Since decades, production traits such as growth rate, feed efficiency or body composition have been drastically increased in pigs by genetic selection. Whether this selection impacted animal robustness is still unclear. In this study, we compared Large White (LW) pigs, a breed submitted to intense genetic selection for production traits, and Basque (B) pigs, a local rustic breed, reared in two different housing environments (conventionalv.enriched). Adaptation to housing conditions among each breed was evaluated at the level of endocrine and immune traits. These are known to be impacted by housing conditions and breed; however, the interaction effects between genotype and environment are less described. Animals (20 per breed and housing environment) entered the experiment at 35 kg of live weight. Levels of cortisol, acute-phase inflammatory proteins, immunoglobulins and hydrogen peroxide, blood formula, lymphocyte proliferation andin-vitrocytokine expression were measured at ∼115 kg of live weight. Animals were checked for skin injuries during the growing period. At slaughter, at the average live weight of 145 kg, carcasses were examined for pathological conditions of the respiratory tract. The major result was that the two breeds exhibited differences in response to the housing environment. Among the 24 sanitary, endocrine or immune traits investigated, the housing conditions affected eight variables in both breeds (salivary cortisol at 0700 and 1900 h, severity of pneumonia at slaughter) or only in B pigs (severe skin lesions) or LW pigs (salivary cortisol at 1500 h, granulocyte numbers and lymphocyte/granulocyte ratio and lymphocyte proliferation). These observations strengthen the hypothesis that selection for high meat production level might be associated with an increased susceptibility of animals to environmental stressors.

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“…In the present study, exercise training decreased the levels of the oxidative stress marker d-ROMs. The usefulness of d-ROMs as an oxidative stress marker has been demonstrated in several studies (28,29), suggesting their association with several diseases (2, 30, 31). In addition, although there was no significant interaction of interventions and time, serum HEL concentrations were significantly decreased in the Ex and S1Ex groups after 12 wk as compared with the baseline values.…”

Section: Discussionmentioning

confidence: 99%

Low-Volume Exercise Training and Vitamin E Supplementation Attenuates Oxidative Stress in Postmenopausal Women

Takahashi

Miyashita

Park

et al. 2013

J Nutr Sci Vitaminol

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SummaryThe purpose of this study was to investigate the effects of low-volume exercise training (90 min/wk) and vitamin E supplementation on oxidative stress markers in postmenopausal women. The participants were non-randomly assigned the following four groups: control (C, n58), vitamin E (S, n58), exercise (Ex, n56), or vitamin E and exercise (S1Ex, n57). The S and S1Ex groups were instructed to take vitamin E (a-tocopherol, 300 mg/d) capsules for 12 wk. The exercise program of Ex and S1Ex groups consisted of walking for a 30-60 min/session 2 d per week for 12 wk. The serum derivatives of reactive oxygen metabolites concentrations were significantly decreased in the Ex, and S1Ex groups after 12 wk compared with the baseline values (three-factor ANOVA, an interaction between exercise and time, p,0.05). Conversely, serum biological antioxidant potential concentrations in the S and Ex groups were significantly higher at 12 wk than at the baseline, but not in the S1Ex group (three-factor ANOVA, an interaction between supplementation, exercise and time, p,0.05). Plasma thioredoxin concentrations in the S, Ex, and S1Ex groups were significantly higher at 12 wk than at the baseline values (three-factor ANOVA, interactions between exercise and time, and between supplementation, exercise and time, p,0.05). Our findings suggest that low-volume physical activity may improve resting oxidative stress status in postmenopausal women.

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Relations between Serum Reactive Oxygen Metabolites (ROMs) and Various Inflammatory and Metabolic Parameters in a Japanese Population

Cited by 46 publications

References 33 publications

Significance of measuring oxidative stress in lifestyle-related diseases from the viewpoint of correlation between d-ROMs and BAP in Japanese subjects

Significance of measuring oxidative stress in lifestyle-related diseases from the viewpoint of correlation between d-ROMs and BAP in Japanese subjects

Health and immune traits of Basque and Large White pigs housed in a conventional or enriched environment

Low-Volume Exercise Training and Vitamin E Supplementation Attenuates Oxidative Stress in Postmenopausal Women

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