Relationship Among Endothelial Response to Hyperemia, Bone Marrow-Derived Progenitor Cells, and Parathyroid Hormone in Renal Transplantation

Fatini, Cinzia; Sticchi, Elena; Cesari, Francesca; Gori, Anna Maria; Cioni, Gabriele; Stefano, Margherita De; Bertoni, E.; Paudice, N.; Salvadori, Maurizio; Zanazzi, M.; Abbate, Rosanna

doi:10.1097/tp.0b013e318247a75d

Cited by 5 publications

(4 citation statements)

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Section: Discussionmentioning

confidence: 99%

“…Moreover, in a group of patients at high risk for vascular events as patients undergo renal transplantation, we found that PAT correlates with endothelial progenitor cells and parathyroid hormone values. 21 The favorable effects of close adherence to Mediterranean diet in improving endothelial function were demonstrated by using FMD methodology. Rallidis et al 11 showed an increase in FMD in 90 subjects with abdominal obesity, but without 22 provided the evidence of an improvement in the postprandial endothelial function, assessed by FMD, in healthy subjects, after acute consumption of both red wine and green olive oil, 2 main components of Mediterranean diet.…”

Section: Discussionmentioning

confidence: 99%

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Peripheral-Arterial Tonometry for Assessing Endothelial Function in Relation to Dietary Habits

Cioni

Boddi

Fatini

et al. 2013

Journal of Investigative Medicine

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BackgroundPeripheral-arterial tonometry (PAT) provides, with good reproducibility, measures of nitric oxide–mediated endothelial response, which correlate with flow-mediated dilation (FMD) findings obtained by brachial artery ultrasound. Few data about the ability of exploring endothelial function by PAT in relation to dietary habits are available. The aim of this study was to evaluate natural logarithm of reactive hyperemia index (lnRHI) in subjects referred for primary prevention, in relation to classic risk factors, in particular to adherence to Mediterranean diet and red wine consumption.MethodsThe study population was composed of 95 consecutive clinically stable subjects in primary prevention for cardiovascular diseases. All subjects underwent medical questionnaire, clinical examination, and PAT for endothelial function evaluation.ResultsA significant inverse correlation between lnRHI values and body mass index (r = −0.284; P = 0.022) was found. We described a gradual reduction in lnRHI values, corresponding to the increase in the number of risk factors (0.75 [0.31–1.26], 0.66 [0.25–0.97], 0.63 [0.37–1.19], 0.48 [0.32–0.71], 0.43 [0.31–0.91], respectively, for none, 1, 2, 3, and 4 cardiovascular risk factors; P = 0.004). A significant positive correlation between score of adherence to Mediterranean diet and lnRHI values was found (r = 0.307; P = 0.002). Higher adherence to Mediterranean diet was found in subjects with lnRHI values greater than 0.40 in comparison to others (39 [27–50] vs 33 [28–45], respectively; P = 0.064). The lnRHI values were significantly higher in regular drinkers in comparison to nonregular drinkers (0.46 [0.25–0.83] vs 0.70 [0.32–1.26], respectively; P < 0.0001).Relationship between reactive hyperemia index and red wine consumption remained statistically significant even after adjustment for age, sex, body mass index, smoking habit, hypertension, and adherence to Mediterranean diet.ConclusionsOur findings strengthen the ability of PAT to evaluate alterations of endothelium response to ischemia, in relation to physiological and clinical conditions, so indicating possible usefulness to optimize and personalize risk stratification.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Peripheral-Arterial Tonometry for Assessing Endothelial Function in Relation to Dietary Habits

Cioni

Boddi

Fatini

et al. 2013

Journal of Investigative Medicine

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“…Plasma SDF-1 level in patients with functioning renal graft was increased when compared to patients with an essential hypertension and normal kidney function (Di Marco et al, 2011). Indices of endothelial dysfunction related to hyperemia were associated with a reduced EPCs number and an increased serum parathyroid hormone concentration (Fatini et al, 2012).…”

Section: Kidney Transplantationmentioning

confidence: 91%

Endothelial progenitor cells participation in cardiovascular and kidney diseases: a systematic review

et al. 2016

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Endothelial progenitor cells (EPCs) represent a small population of blood cells (5-40 cells/mm(3)), with an ability to differentiate into endothelial cells that form the lining of the blood vessels and contribute to postnatal angiogenesis. Abundant evidence shows that recruitment of EPCs from the bone marrow, the monocyte/macrophage lineage and the organs facilitate the endothelial regeneration and repair. Changes in the number of EPCs were observed in both, chronic kidney and cardiovascular diseases. Thus, these cells were tested for usage in diagnosis and therapy. In this paper, we review the current knowledge on the EPC biology and contribution of these cells to the kidney and cardiovascular diseases.

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“…An extensive description of this method and of the analyses algorithm was provided elsewhere [16]. According to literature [17], Ln-RHI>0.4 was considered as cut off for normal values. We performed PAT assessment at T0, T1, T2 and T3.…”

Section: Reactive Hyperaemia By Peripheral Arterial Tonometrymentioning

confidence: 99%

The Impact of a Single Apheretic Procedure on Endothelial Function Assessed by Peripheral Arterial Tonometry and Endothelial Progenitor Cells

Cioni¹

2017

Arch Vas Med

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Introduction: Endothelial progenitor cells (EPC) are involved in vascular repair and proliferation, contributing to the long-term outcomes of apheretic treatment. Aim of this study was to investigate the relationships between endothelial function, assessed by levels of bone marrow-derived progenitor cells and endothelial response to hyperaemia, and clinical and biohumoral parameters in high vascular risk patients before, immediately after, 24-hours and 72 hours after a single lipid apheresis procedure. Material and Methods:We evaluated lipid profi le, endothelial function and endothelial progenitor cells before (T0), immediately after (T1), 24h after (T2) and 72h after (T3) a lipoprotein apheresis procedure, in 8 consecutive patients [Sex: 62.5% M; Age; 63.29(12), mean, (range) years] with a personal history of acute coronary syndrome, symptomatic peripheral arterial disease and elevated plasma levels of lipoprotein (a) [Lp(a)]. Patients were on regularly weekly or biweekly lipoprotein apheresis, and they were treated with the FDA-approved Heparin-induced Extracorporeal LDL Precipitation (H.E.L.P.) (Plasmat Futura, B.Braun, Melsungen, Germany) technique. PAT values were expressed as the natural logarithm (Ln-RHI, normal values≥0.4) of the reactive hyperaemia index (RHI), which is the parameter automatically calculated by the device. Results:We found a reduction in the natural logarithm of reactive hyperaemia index (Ln-RHI), assessed immediately after the procedure (0.57±0.21 vs 0.72± 0.29); difference between T2 and T0 was statistically signifi cant (0.43±0.24 vs 0.72±0.29; p=0.006). Reduction in Ln-RHI values was documented in all patients, two subjects showing a Ln-RHI<0.4 at T1, and four at T2. At T3, PAT values were increased signifi cantly (0.91±0.18) in comparison to T1 and T2, showing a median value higher than at T0. Cd34+/Kdr+ and Cd133+/Kdr+ showed a minimum increase in median values at T1, and a higher increase at T2, in comparison to baseline. Differences in Cd34+/133+/Kdr+ values at different times were not statistically signifi cant. A signifi cant reduction in circulating endothelial cells (CEC) count at T2 in comparison to T0 was found (12.00±8.85 vs 23.86±12.39; p=0.024). Discussion:At 24h and 72h after procedures, we found an improvement in endothelial function, expressed by an increase in PAT values and EPC levels, and by a reduction in CEC.

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Relationship Among Endothelial Response to Hyperemia, Bone Marrow-Derived Progenitor Cells, and Parathyroid Hormone in Renal Transplantation

Abstract: This study shows an altered endothelial response, associated with reduced EPCs, and increased PTH in RTRs; the evaluation of endothelial status in RTRs may contribute to better assess the risk profile of these patients.

Cited by 5 publications

References 30 publications

Peripheral-Arterial Tonometry for Assessing Endothelial Function in Relation to Dietary Habits

Peripheral-Arterial Tonometry for Assessing Endothelial Function in Relation to Dietary Habits

Endothelial progenitor cells participation in cardiovascular and kidney diseases: a systematic review

The Impact of a Single Apheretic Procedure on Endothelial Function Assessed by Peripheral Arterial Tonometry and Endothelial Progenitor Cells

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