Relationship between 25 hydroxyvitamin D and lipid profile in Lebanese school children

Gannagé‐Yared, Marie‐Hélène; Sabbagh, Ramsey S.; Chedid, Rima

doi:10.1007/s40618-018-0840-1

Cited by 8 publications

(2 citation statements)

References 41 publications

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“…Results from cross-sectional studies in children and adolescents revealed an inverse association between vitamin D status and cardiometabolic risk markers, in particular insulin resistance, fasting glucose (FG), triglycerides (TRG), non-high density lipoprotein (Non-HDL), low density lipoprotein (LDL), apolipoprotein B (ApoB), and hypertension as well as a positive association with HDL and apolipoprotein A1 (ApoA1) (14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26) although not all studies reported associations (27,28).…”

Section: Introductionmentioning

confidence: 99%

Longitudinal Associations Between Vitamin D Status and Cardiometabolic Risk Markers Among Children and Adolescents

Wolters

Marron

Foraita

et al. 2023

The Journal of Clinical Endocrinology &Amp; Metabolism

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Background Vitamin D status has previously been associated with cardiometabolic risk markers in children and adolescents. In particular, it has been suggested that children with obesity are more prone to vitamin D deficiency and unfavorable metabolic outcomes compared to healthy-weight children. However, to date, there have been few longitudinal studies assessing this association in children stratified by BMI category. Methods Children from the pan-European IDEFICS/I.Family cohort with at least one measurement of serum 25-hydroxyvitamin D (25(OH)D) at cohort entry or follow-up (n=2,171) were included in this study. Linear mixed-effect models were used to assess the association between serum 25(OH)D as an independent variable and z-scores of cardiometabolic risk markers [waist circumference (WC), systolic (SBP) and diastolic blood pressure (DBP), high (HDL) and low density lipoprotein, non-HDL, triglycerides (TRG), apolipoprotein A1 and B (ApoB), fasting glucose (FG), homeostatic model assessment for insulin resistance (HOMA-IR), metabolic syndrome score] as dependent variables. Results After adjustment for age, sex, study region, smoking and alcohol status, sports club membership, screen time, BMI, parental education, and month of blood collection, 25(OH)D levels were inversely associated with SBP, DBP, FG, HOMA-IR and TRG. The HOMA-IR z-score decreased by 0.07 units per 5 ng/ml increase in 25(OH)D. 25(OH)D was consistently associated with HOMA-IR irrespective of sex or BMI category. Conclusion Low serum 25(OH)D concentrations are associated with unfavorable levels of cardiometabolic markers in children and adolescents. Interventions to improve vitamin D levels in children with a poor status early in life may help to reduce cardiometabolic risk.

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Section: Introductionmentioning

confidence: 99%

Longitudinal Associations Between Vitamin D Status and Cardiometabolic Risk Markers Among Children and Adolescents

Wolters

Marron

Foraita

et al. 2023

The Journal of Clinical Endocrinology &Amp; Metabolism

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“…Розпочато вивчення ролі цього вітаміну в дорослих при цукровому діабеті 2-го типу, серцево-судинній патології, злоякісних пухлинах, інфекційних хворобах (туберкульозі); показана висока частота його дефіциту при ожирінні [7]. Вітамін D чинить суттєвий вплив на кальцієвий обмін, метаболізм кальційзалежних гормонів і ліпідний профіль [8,9]. Крім того, показано, що в дітей дефіцит цього вітаміну дуже небезпечний, оскільки може призводити до гіпокальціємічних станів, переломів, затримки розвитку й формування кісток і зубів, анемії, кардіореспіраторних станів і навіть летального наслідку [10].…”

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An interaction between growth hormone/insulin-like growth factor-1 and vitamin D in children with short stature

Bolshova

Kvacheniuk

Muz

et al. 2022

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There are disorders in the growth hormone (GH)/growth factors system in a significant part of patients with short stature; first of all, this concerns such diseases as growth hormone deficiency, where there is a sharp decrease in GH, insulin-like growth factor-1 (IGF-1). The association between vitamin D and GH/growth factor system remains unclear. It was found that vitamin D is able to increase IGF-1 level in healthy individuals. Linear growth is accelerated after treatment of vitamin D deficiency in children, which may indicate the linking role of vitamin D between the proliferative cells of the growth plate cartilage and GH/growth factor system.Research objective: to determine 25-hydroxyvitamin D level in blood plasma in children with short stature, depending on the state of GH/IGF-1 system.Materials and methods. Study included 101 children with short stature: 33 children with partial somatotropic insufficiency (group 1); 44 children with complete somatotropic insufficiency (group 2); 24 children with syndrome of biologically inactive GH (group 3). Patients in groups 1 and 2 had a confirmed GH deficiency and a decrease or sharp decrease in of IGF-1 level; patients in group 3 had a normal stimulated release of GH against the background of a reduced IGF-1 level. GH, IGF-1, 25-hydroxyvitamin D, thyroid-stimulating hormone, and free thyroxine were determined in all children.Results. The average level of vitamin D in three groups corresponded to the vitamin deficiency according to international standards and was 52.24 ± 5.99 nmol/l in patients with partial somatotropic insufficiency, 67.6 ± 5.35 nmol/l in patients with complete somatotropic insufficiency and 58, ± 7.91 nmol/l in patients with syndrome of biologically inactive GH. A direct correlation was found between vitamin D and background GH level, stimulated GH level in children with both partial and complete somatotropic insufficiency. A direct correlation between vitamin D and IGF-1 level in this group of patients was also detected.Conclusions. It is advisable to determine the serum 25(OH)D in all children with short stature. Vitamin D levels should be taken into account in insulin/clonidine diagnostic tests in order to obtain a realistic indication of stimulated GH and IGF-1 levels.

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Vitamin D is negatively associated with triglyceride in overweight/obese patients with type 2 diabetes

Gong

Han

et al. 2022

Endocrine

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Relationship between 25 hydroxyvitamin D and lipid profile in Lebanese school children

Abstract: An independent relationship is observed between 25(OH)D and cardiometabolic risk factors in the pediatric Lebanese population Further studies are needed to evaluate the long-term consequences of this relationship.

Cited by 8 publications

References 41 publications

Longitudinal Associations Between Vitamin D Status and Cardiometabolic Risk Markers Among Children and Adolescents

Longitudinal Associations Between Vitamin D Status and Cardiometabolic Risk Markers Among Children and Adolescents

An interaction between growth hormone/insulin-like growth factor-1 and vitamin D in children with short stature

Vitamin D is negatively associated with triglyceride in overweight/obese patients with type 2 diabetes

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