Relationship between 5,10-methylenetetrahydrofolate reductase C677T gene polymorphism and methotrexate related toxicity in patients with autoimmune diseases receiving folic acid supplementation

Methotrexate pharmacogenetics: The first step toward individualized therapy in rheumatoid arthritis

“…Surprisingly, toxicity was more frequent in patients with the wild‐type (CC) genotype as compared with those who carried the polymorphism ( P = 0.005). The authors postulated a protective effect of the MTHFR C677T SNP on MTX toxicity, although it should be noted that the number of patients in this study was small; it is unclear how many of the patients had RA, and no details on MTX dosage and toxicity were provided (64).…”

“…A more recent study genotyped 63 patients with autoimmune diseases who were taking MTX and folate supplements for the MTHFR C677T polymorphism (64). Toxicity information was collected retrospectively.…”

Associations between single-nucleotide polymorphisms of RFC-1, GGH, MTHFR , TYMS, and TCII genes and the efficacy and toxicity of methotrexate treatment in patients with rheumatoid arthritis

“…30 Different results were obtained in a study of 63 patients with RA, psoriatic arthritis, polymyositis, and ankylosing spondylitis. 31 The study showed that adverse effects were more common in a group of patients with the 677CC genotype. It should be noted that the study group was heterogeneous in relation to the type of disease, the number of patients was low, and adverse effects were analyzed as a whole.…”

“…It should be noted that the study group was heterogeneous in relation to the type of disease, the number of patients was low, and adverse effects were analyzed as a whole. 31 In 3 other studies on occurrence of adverse effects, especially in combination with the TYMS 3-UTR 6-bp del allele. 20 Different results related to the RFC-1 polymorphism and adverse effects were obtained by other investigators.…”

The Relationship of Plasma Homocysteine Levels and the Methylenetetrahydrofolate Reductase C677T Gene Polymorphism to Ankylosing Spondylitis in a Chinese Population

“…In the treatment of cancer and rheumatic diseases, the polymorphism of MTHFR C677T can increase the incidence of methotrexate toxicity, but folic acid supplements can reduce the toxicity of methotrexate and do not affect the treatment. [15,16] This prompted us to hypothesize that certain nutritional factors may be related to the incidence and treatment of AS. It is likely that a complicated process related to the control of gene cytokines and other factors has led to the incidence of AS, but the specific mechanisms still need further study.…”