Relationship Between A Range of Tissue Temperature and Local Oxygen Uptake in the Human Forearm. II. Changes Observed After Arterial Occlusion, in the Period of Reactive Hyperemia12

Relationship Between a Range of Tissue Temperature and Local Oxygen Uptake in the Human Forearm. Iii. Changes Observed After Anaerobic Work, in the Postexercise Period*†

“…were approximately the same as the figures reported in previous papers (4,5). The difference observed between the average resting oxygen uptake at a bath temperature of 45°and that at 28 to 300 (Table I) was found to be statistically significant, with a p < 0.01 (8).…”

“…Nevertheless, it is necessary to know whether or not the change due to anoxia alone was of equal magnitude at the two bath temperatures. Of interest in this respect is the observation in a previous study (5) that the oxygen repayment following a five minute period of arterial occlusion, in excess of the baseline, was significantly greater at a higher than at a lower tissue temperature. On the basis of such findings, it would be safe to assume that if there had been a difference in the response to the one-half minute of arterial occlusion at the two bath temperatures, this would have manifested itself in the form of an increase in the excess oxygen uptake at the higher level, thus making the calculated difference between this figure and the one obtained at the lower bath temperature less than the true value.…”

“…Immediately after the termination of the exercise and the release of the arterial occlusion pressure on the arm, blood flow readings (Figure 1), venous blood samples and temperature recordings were obtained at rapid intervals, generally three or four in the first minute of the postexercise period, two in the second and five spaced over the next 10 to 20 minutes. In every instance care was taken not to draw a blood sample at the same time as blood flow was being recorded (5). After the various readings had returned to the preexercise baseline, the bath temperature was changed to either the higher or the lower one, depending upon which had been used initially 2 and the procedure already de- 2 The order in which the experiments were performed in no way affected the results.…”

“…This approach was undertaken because of the data previously obtained indicating that the resting oxygen uptake (4) and the oxygen debt resulting from five minutes of arterial occlusion (5) were increased by raising tissue temperatures and decreased by low-t This paper was presented before the Thirty-first Annual Meeting of the Central Society for Clinical Research, Chicago, Illinois, October 31 and November 1, 1958. ering them. Anaerobic exercise was used in order to ascertain accurately the entire oxygen debt through a study of the excess oxygen repayment in the postexercise period.…”

Local Temperature Changes and Human Skeletal Muscle Metabolism.

“…This observation seems to be in agr eement with nea r i nfrar ed measurem ents o f haemoglobin saturation, were it was demonstrated that, for 4-5 min arterial occlusion at normothermia, the metabolism of the forearm (Hamaoka et al, 1996) or calf (Binzoni et al, 1998) may remain reasonably aerobic. At low temperature, due to vasoconstriction, blood stores should be reduced and thus the measured O 2 debt values should be near the theoretical values (Abramson et al, 1958b). Binzoni et al (1999) and Binzoni et al (2001) found, by near infrared spectroscopy, a Q 10 value of ~2 for the human "forearm" muscle O 2 ) 355 ± 71, 343 ± 134, 285 ± 38 and 381 ± 102 ml min-1 at 35.3 ± 0.4, 35.4 ± 0.4, 38.9 ± 0.1 and 38.6 ± 0.3°C (vastus lateralis), respectively.…”