Relationship between ABO blood groups and von Willebrand factor, ADAMTS13 and factor VIII in patients undergoing hemodialysis

Rios, Danyelle Romana Alves; Fernandes, Ana Paula; Figueiredo, Rachel; Guimarães, Daniela Amorim Melgaço; Ferreira, Cláudia N.; Silva, Ana Cristina Simões e; Carvalho, Maria G.; Gomes, Karina Braga; Dusse, Luci Maria Sant’Ana

doi:10.1007/s11239-012-0719-5

Cited by 19 publications

(17 citation statements)

References 33 publications

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“…In both arterial and venous thromboembolism, non-O (A, B, or AB) individuals show significantly increased risk (Franchini & Mannucci, 2014; Liumbruno & Franchini, 2013), whereas group O individuals have more pronounced inherited bleeding tendency and von Willebrand disease (Gallinaro et al, 2008; Rios et al, 2012). A scientific basis for this result is that ABO blood group determines the two coagulation glycoproteins levels VWF and FVIII (Song et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…The proteolysis appears to be faster in group O subjects than in non-O carriers (O’Donnell et al, 2005). The differences in glycane structure between group O and non-O individuals could alter the susceptibility of VWF for cleavage by ADAMTS13 (a disintegrin-like and metalloprotease with thrombospondin type I motif, 13), which affects the conformation of VWF and the accessibility of the ADAMTS13 cleavage site (Casari et al, 2013; O’Donnell et al, 2005; Rios et al, 2012). The effects of ABO blood groups on FVIII are mainly mediated by an effect on VWF antigen levels, but several other factors (e.g., pregnancy and use of oral contraceptive) are also correlated with FVIII levels (Rios et al, 2012; Song et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Influences of ABO blood group, age and gender on plasma coagulation factor VIII, fibrinogen, von Willebrand factor and ADAMTS13 levels in a Chinese population

Wang

Dou

et al. 2017

PeerJ

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BackgroundABO blood group is a hereditary factor of plasma levels of coagulation factor VIII (FVIII) and von Willebrand factor (VWF). Age and gender have been shown to influence FVIII, VWF, fibrinogen (Fbg), and ADAMTS13 (A disintegrin and metalloprotease with thrombospondin type 1 motif, 13). We investigated the effects of ABO type, age, and gender on plasma levels of FVIII, Fbg, VWF, and ADAMTS13 in a Chinese population.MethodsA total of 290 healthy volunteers were eligible for this study. ABO blood group was determined by indirect technique. FVIII:C and Fbg were measured by clotting assays. VWF antigen (VWF:Ag), collagen-binding activity (VWF:CBA), and ADAMTS13 antigen were assessed by ELISA, whereas VWF ristocetin cofactor activity (VWF:Rcof) was performed by agglutination of platelets with ristocetin.ResultsMean FVIII:C and VWF levels (VWF:Ag, VWF:CBA, and VWF:Rcof) were significantly higher in non-O than in O type subjects (p < 0.05 for all comparison). ADAMTS13 antigen decreased with increasing age, whereas the other parameters increased. Other than ADAMTS13 (p < 0.01), no gender-related variations were observed in the other parameters. Moreover, FVIII:C, Fbg, VWF:Ag, VWF:CBA, and VWF:Rcof showed significant and positive relationships with age (r = 0.421, 0.445, 0.410, 0.401, and 0.589, resp.; all p < 0.001), whereas a negative relationship was observed for ADAMTS13 antigen (r = 0.306; p = 0.006). Furthermore, FVIII:C were strongly correlated with VWF:Ag, VWF:CBA, and VWF:Rcof (r = 0.746, r = 0.746, and r = 0.576, resp.; p < 0.0001). VWF parameters were also strongly correlated with each other (r = 0.0.847 for VWF:Ag and VWF:CBA; r = 0.722 for VWF:Ag and VWF:Rcof; p < 0.0001).ConclusionsABO blood group, age, and gender showed different effects on plasma levels of FVIII:C, Fbg, VWF:Ag, VWF:CBA, VWF:Rcof, and ADAMTS13 antigen. These new data on a Chinese population are quite helpful to compare with other ethnic groups.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Influences of ABO blood group, age and gender on plasma coagulation factor VIII, fibrinogen, von Willebrand factor and ADAMTS13 levels in a Chinese population

Wang

Dou

et al. 2017

PeerJ

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“…Interestingly, non-O blood group predisposes to venous thromboembolism compared to O blood group [8] but the exact mechanism for this vascular risk is not completely understood [9]. One possible explanation could be related to plasma von Willebrand factor [10] (VWF) since ABO (H) blood group plays a role in its secretion [11] and clearance [11][12][13]. VWF is a multimeric protein [14], which is involved in several pathophysiological process where thrombosis is a feature [15].…”

Section: Introductionmentioning

confidence: 99%

ABO blood group in primary antiphospholipid syndrome: influence in the site of thrombosis?

Nascimento

Bydlowski

Soares

et al. 2015

J Thromb Thrombolysis

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Antiphospholipid syndrome (APS) is characterized by vascular thrombosis and/or obstetric complications associated with presence of antiphospholipid antibodies (aPL) but additional factors would also induce thrombosis. ABO (H) blood groups are known to be closely related to thrombosis, especially non-O blood type with venous events. The aim of this study was to investigate possible role of ABO (H) blood types in the thrombotic events in primary APS (PAPS). Seventy PAPS patients were selected for the study and were divided according to ABO blood group in: O PAPS (n = 26) and non-O PAPS (n = 44). ABO blood group phenotyping was performed by indirect technique. aPL anticardiolipin (aCL) and anti-βeta2 glycoprotein-1 (aβ2GPI) and the concentrations and activities of von Willebrand factor (VWF) were measured with ELISA. Lupus anticoagulant (LA) was detected by coagulation assays. A significant higher frequency of venous events was observed in non-O PAPS group (72.7 vs. 46.2 %, p = 0.040). In contrast, the frequency of arterial events was significantly higher in the O PAPS compared to the non-O PAPS group (69.2 vs. 36.4 %, respectively; p = 0.013). Frequencies of aCL, LA, aβ2GPI and triple aPL positivity were similar in both groups (p > 0.05). VWF antigen (75.54 ± 8.68 vs. 79.51 ± 7.07 IU/dl, p = 0.041) and activity (70.23 ± 11.96 vs. 77.92 ± 13.67 %, p = 0.020) were decreased in O PAPS compared to non-O blood group. VWF:CB/VWF:Ag ratio was similar among groups (p > 0.05). This is the first report that confirms the role of ABO blood system in thrombosis of PAPS and suggests that non-O blood group was related with venous events and O blood group with arterial thrombosis.

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“…Rios et al [15] found increased vWF levels and reduced ADAMTS13 activity without a significant correlation with the occurrence of vascular access thrombosis. We did not find decreased ADAMTS13 activity, similar to results obtained by Holden et al [16] who found increased levels of vWF antigen and activity, but no significant changes in ADAMTS13 activity in 55 patients on chronic HD.…”

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confidence: 99%

Effect of Vitamin D Status on Von Willebrand Factor and ADAMTS13 in Diabetic Patients on Chronic Hemodialysis

et al. 2017

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Von Willebrand factor (vWF) is a glycoprotein with a crucial role in the formation of platelet thrombi, and ADAMTS13 is the main enzyme responsible for vWF cleavage. Both are important in the relationship between diabetic nephropathy, hypercoagulability, and cardiovascular disease. This study evaluated a potential relationship between vitamin D (vitD) levels, vWF, ADAMTS13 activity, and inflammation in diabetic patients on chronic hemodialysis (HD). Blood samples from 52 diabetic patients on chronic HD were obtained to determine vitD levels, vWF, and ADAMTS13 activity, and inflammatory markers. HD patients were grouped according to 25-hydroxyvitamin D [25(OH) VitD] < 25 nmol/L (n = 16) or > 25 nmol/L (n = 36). vWF antigen and vWF activity were elevated in both groups, with an average of 214.3 ± 82.6% and 175.8 ± 72.6%, respectively. Average ADAMTS13 activity was within the normal range in both groups. Blood samples from the vitD < 25 nmol/L group showed a positive correlation between c-reactive protein (CRP) and vWF levels (P = 0.023; r = 0.564; 95% confidence interval = 0.095-0.828), with a negative correlation between HbA1c and 25(OH) VitD (P = 0.015; r = -0.337; 95% confidence interval = -0.337-0.19). Diabetic patients on chronic HD had elevated vWF levels and activity with no significant change in ADAMTS13 activity. The correlation between CRP and vWF levels in the 25(OH) VitD < 25 nmol/L group suggests inflammatory-related endothelial dysfunction in these patients.

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Relationship between ABO blood groups and von Willebrand factor, ADAMTS13 and factor VIII in patients undergoing hemodialysis

Cited by 19 publications

References 33 publications

Influences of ABO blood group, age and gender on plasma coagulation factor VIII, fibrinogen, von Willebrand factor and ADAMTS13 levels in a Chinese population

Influences of ABO blood group, age and gender on plasma coagulation factor VIII, fibrinogen, von Willebrand factor and ADAMTS13 levels in a Chinese population

ABO blood group in primary antiphospholipid syndrome: influence in the site of thrombosis?

Effect of Vitamin D Status on Von Willebrand Factor and ADAMTS13 in Diabetic Patients on Chronic Hemodialysis

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