Relationship between adolescent amenorrhea and climacteric osteoporosis

Csermely, Tamás; Halvax, László; Vizer, Miklós; Drozgyik, I.; Tamás, Péter; Göcze, Péter M.; Szabó, István; Jeges, Sára; Szilágyi, András

doi:10.1016/j.maturitas.2006.10.003

Cited by 7 publications

(6 citation statements)

References 37 publications

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“…In a recent study by our group in Asian patients with schizophrenia, 18/21 (86%) of women with schizophrenia treated with haloperidol had significant bone mineral density loss as compared to 9/23 (39%) of women in the normal control group [15]. Other recent evidence suggests that having amenorrhea or using prolactin elevating antipsychotic drugs are associated with a higher risk for osteoporosis and fracture [79-82]. Very recently, Graham and others [83] published a literature review showing that first generation antipsychotics and certain second generation agents such as risperidone show high prolactin elevations and are associated with an increased risk of osteoporosis and fracture.…”

Section: Introductionmentioning

confidence: 99%

Treating symptomatic hyperprolactinemia in women with schizophrenia: presentation of the ongoing DAAMSEL clinical trial (Dopamine partial Agonist, Aripiprazole, for the Management of Symptomatic ELevated prolactin)

et al. 2013

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Prolactin elevations occur in people treated with antipsychotic medications and are often much higher in women than in men. Hyperprolactinemia is known to cause amenorrhea, oligomenorrhea, galactorrhea and gynecomastia in females and is also associated with sexual dysfunction and bone loss. These side effects increase risk of antipsychotic nonadherence and suicide and pose significant problems in the long term management of women with schizophrenia. In this manuscript, we review the literature on prolactin; its physiology, plasma levels, side effects and strategies for treatment. We also present the rationale and protocol for an ongoing clinical trial to treat symptomatic hyperprolactinemia in premenopausal women with schizophrenia. More attention and focus are needed to address these significant side effects and help the field better personalize the treatment of women with schizophrenia.

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Section: Introductionmentioning

confidence: 99%

Treating symptomatic hyperprolactinemia in women with schizophrenia: presentation of the ongoing DAAMSEL clinical trial (Dopamine partial Agonist, Aripiprazole, for the Management of Symptomatic ELevated prolactin)

et al. 2013

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“…Osteoporosis apabila T-score SD< -2,5. 16 Female athlete triad (FAT) merupakan tiga kondisi yang saling berkaitan, yaitu penyimpangan perilaku makan, gangguan menstruasi, dan kepadatan tulang rendah yang terjadi pada subjek. 5,8 Analisis data menunjukan hasil distribusi dan frekuensi.…”

Section: Metode Penelitianunclassified

“…Hal ini dapat mempengaruhi berkurangnya produksi estrogen yang mempunyai pengaruh signifikan dalam metabolisme mineral tulang. 16 Kurangnya estrogen pada masa remaja dapat menyebabkan penurunan kepadatan tulang dan dapat berakibat osteoporosis. Estrogen berperan dalam proses mineralisasi tulang dan menstimulasi aktivitas osteoblas, dan penurunan estrogen meningkatkan aktivitas osteoklas, dimana terjadi ketidakseimbangan pembentukan kembali tulang dan lebih banyak terjadi resorpsi sehingga menyebabkan kepadatan tulang rendah.…”

Section: Kepadatan Tulangunclassified

Ketidakpuasan Terhadap Citra Tubuh Dan Kejadian Female Athlete Triad (Fat) Pada Remaja Putri

Yuliana¹,

Dieny²

2013

J. NutriColl

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Latar Belakang : Kekhawatiran citra tubuh pada remaja putri yang menginginkan bentuk tubuh ramping dengan berat badan kurang dapat mempengaruhi terjadinya female athlete triad (FAT). FAT merupakan tiga kondisi yang saling berkaitan, yaitu penyimpangan perilaku makan, gangguan menstruasi, dan kepadatan tulang rendah. Tujuan penelitian mengetahui gambaran ketidakpuasan terhadap citra tubuh dan prevalensi female athlete triad pada remaja putri.Metode : Penelitian ini merupakan penelitian deskriptif bertempat di SMA Negeri 1 Semarang. Jumlah sampel 91 subjek yang dipilih dengan metode propotional stratified random sampling. Data penelitian meliputi identitas, berat badan, tinggi badan, persen lemak tubuh, dan kepadatan tulang. Penilaian citra tubuh menggunakan Body Shape Questionaire (BSQ). Penilaian status gizi menggunakan z-score IMT/U dan persen lemak tubuh, pengukuran persen lemak tubuh menggunakan body fat analyzer. Penilaian penyimpangan perilaku makan menggunakan eating disorder diagnostic scale (EDDS). Penilaian gangguan menstruasi menggunakan kuesioner. Penilaian kepadatan tulang menggunakan quantitative ultrasound bone densitometry.Hasil : Subjek yang merasa tidak puas terhadap citra tubuhnya (merasa gemuk) sebanyak 42 subjek (46.2%). Delapan belas subjek (19.8%) mengalami Eating Disorder Not Otherwise Specified (EDNOS). Subjek dengan gangguan menstruasi sebanyak 25 subjek (27.5%). Subjek dengan kepadatan tulang rendah 23 subjek (25.3%). Pada penelitian ini ditemukan subjek yang mengalami female athlete triad (FAT) sebanyak 2 subjek (2.2%).Simpulan : Sebanyak 46.2% subjek memiliki ketidakpuasan citra tubuh, dan prevalensi FAT di SMA N 1 Semarang sebesar 2.2%.

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“…Low weight or hyperprolactinemia can cause low estrogen levels and subsequent amenorrhea. Secondary amenorrhea during the years of adolescence may play a role in the development of osteoporosis or osteopenia in later years 15 . A diagnosis for the cause of amenorrhea needs to be made, and the issues discussed with the patient and her family, so that an appropriate plan can be devised.…”

Section: Issues Specific To the Menstrual Cycles Of Teens With Ddmentioning

confidence: 99%

Menstrual Issues in Adolescents with Physical and Developmental Disabilities

Quint

2008

Annals of the New York Academy of Sciences

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Puberty and menstruation are difficult issues for teens with disabilities and for their families as well. Irregular bleeding, mood swings, and problems with hygiene often complicate the delicate balance in the lives of these adolescents. The care provider is asked to help with the pubertal transition and the issues surrounding menstruation and reproductive health. This review will concentrate on the issues concerning menstruation that need special focus in teens with developmental disability (DD). The impact of the menstrual cycle on these teenagers, including hygiene issues, menstrual irregularities due to specific clinical circumstances, and treatment dilemmas associated with the use of hormonal medication will be discussed for this special group of teens.

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Relationship between adolescent amenorrhea and climacteric osteoporosis

Cited by 7 publications

References 37 publications

Treating symptomatic hyperprolactinemia in women with schizophrenia: presentation of the ongoing DAAMSEL clinical trial (Dopamine partial Agonist, Aripiprazole, for the Management of Symptomatic ELevated prolactin)

Treating symptomatic hyperprolactinemia in women with schizophrenia: presentation of the ongoing DAAMSEL clinical trial (Dopamine partial Agonist, Aripiprazole, for the Management of Symptomatic ELevated prolactin)

Ketidakpuasan Terhadap Citra Tubuh Dan Kejadian Female Athlete Triad (Fat) Pada Remaja Putri

Menstrual Issues in Adolescents with Physical and Developmental Disabilities

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