Relationship Between Aging and Susceptibility of Erythrocytes to Oxidative Damage: In View of Nutraceutical Interventions

Marotta, Francesco; Pavasuthipaisit, K.; Yoshida, Chikako; Albergati, Francesco; Marandola, P.

doi:10.1089/rej.2006.9.227

Cited by 21 publications

(18 citation statements)

References 14 publications

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“…Scientific literature indicated that liver and kidney damage which is indicative of toxicity of treatment agents ultimately produces inflammation which is measurable through the haematology indices (Marrota et al 2006). The current study revealed no effect of dietary cabbage on the haematological parameters as measured here, and this showed the data point on the safety of cabbage and its potential utility as a non-conventional feedstuff for poultry.…”

Section: Effect Of Dietary Cabbage Level On Haematology Irrespective supporting

confidence: 45%

Nutritive effect of cabbage (<i>Brassica oleracea</i>) on growth, obesity, lipidaemia and haematology in broiler and pullet chickens

Adesina¹,

Toye²

2015

Global Journal of Agricultural Sciences

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Efficacy of cabbage (Brassica oleracea) for ameliorating the adverse metabolic syndrome side-effects of genetically improved growth rate in chickens was examined. Sixty-four (64) day-old birds (32 Marshall Broilers and 32 Harco Black Pullets) were randomly assigned to groups of eight genotype-matched birds in a 2-factor layout within a Completely Randomized Design (CRD). Within genotype, each group was randomly assigned one of four diets (basal/control diet containing 0% cabbage, and, basal diet supplemented with 3%, 6% or 12% cabbage) for 4 weeks. All birds were fed an un-supplemented Broiler finisher diet from week 4 -8. Bodyweight and Body Mass Index (BMI) were determined weekly. Blood Packed Cell Volume (PCV), Haemoglobin (Hb), White Blood Cells (WBC), Red Blood Cells (RBC), neutrophils, lymphocytes, monocytes, basophils and eosinophils), Total serum Cholesterol (TC), High Density Lipoprotein (HDL) and Low Density Lipoprotein (LDL) were determined at age 4 weeks. Irrespective of diet or age, Broilers exhibited significantly greater (p<0.05) body weight, adiposity, and lipidaemia than Pullets, and no interactions between cabbage and genotype were observed for the same traits. Dietary cabbage at 3%, irrespective of genotype significantly (p<0.05) improved body weight beyond week 5 while no significant effect was observed on body fatness as measured by BMI. Cabbage supplementation suppressed broiler eosinophil levels, indicating effects on mediators of innate immune surveillance, but did not influence any other blood haematological parameter, though Broilers exhibited higher (p<0.05) total WBC count and proportion (%) of WBC represented by neutrophils, basophils and eosinophils. In Contrast, Pullets exhibited higher RBC, PCV, and Hb, and lymphocyte and monocyte differential counts. Dietary Cabbage had a nutrigenetic effect on cholesterol: Reduced TC and LDL in Broilers in contrast to its effect in increasing the same lipids in Pullets. Cabbage however lowered HDL Cholesterol (p<0.05) in both genotypes, though the threshold of effect was higher (12%) in Pullets (3%). Thus Cabbage is effective in lowering heart disease risk through lowering of lipidaemia in Broilers, and improves bodyweight at market age (7-8 weeks) at 3% dietary supplementation level.

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Section: Effect Of Dietary Cabbage Level On Haematology Irrespective supporting

confidence: 45%

Nutritive effect of cabbage (<i>Brassica oleracea</i>) on growth, obesity, lipidaemia and haematology in broiler and pullet chickens

Adesina¹,

Toye²

2015

Global Journal of Agricultural Sciences

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“…Induction of p47phox phosphorylation as well as upregulation of Rac2 transcription emerged as two potential underlying mechanisms. Because FPP has a long track-record of safe human consumption (1,(27)(28)(29)44) and has proved to be beneficial in influencing wound healing outcomes (15), findings of this study lay a strong rationale for the design of phase-II clinical trial testing the effects of FPP supplementation on wound infection outcomes of type II diabetes mellitus patients suffering from chronic wounds.…”

Section: Innovationmentioning

confidence: 96%

“…Fermented papaya preparation (FPP), a granular substance, is available over the counter (32). FPP possesses antioxidant properties (3,11,22,35) that provide benefit against age-related complications (27). FPP is also known to protect red blood cells against oxidative damage (27,28) and help against severe forms of thalassemia (1).…”

Section: Innovationmentioning

confidence: 99%

“…FPP possesses antioxidant properties (3,11,22,35) that provide benefit against age-related complications (27). FPP is also known to protect red blood cells against oxidative damage (27,28) and help against severe forms of thalassemia (1). Several independent observations convergently point toward the hypothesis that treatment with papaya preparations may facilitate wound healing responses (2,17,21,30,33,34).…”

Section: Innovationmentioning

confidence: 99%

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Correction of Aberrant NADPH Oxidase Activity in Blood-Derived Mononuclear Cells from Type II Diabetes Mellitus Patients by a Naturally Fermented Papaya Preparation

Dickerson

Deshpande

Gnyawali

et al. 2012

Antioxidants & Redox Signaling

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Supplementation of standardized fermented papaya preparation (FPP) to adult diabetic mice improves dermal wound healing outcomes. Peripheral blood mononuclear cells (PBMC) from type II diabetes mellitus (T2DM) patients elicit a compromised respiratory burst activity resulting in increased risk of infections for the diabetic patients. Aims: The objectives of the current study were to determine the effect of FPP supplementation on human diabetic PBMC respiratory burst activity and to understand underlying mechanisms of such action of FPP. Results: When stimulated with phorbol 12-myristate 13-acetate, the production of reactive oxygen species by T2DM PBMC was markedly compromised compared to that of the PBMC from non-DM donors. FPP treated ex vivo improved respiratory burst outcomes in T2DM PBMC. FPP treatment significantly increased phosphorylation of the p47phox subunit of NADPH oxidase. In addition, the protein and mRNA expression of Rac2 was potently upregulated after FPP supplemention. The proximal human Rac2 gene promoter is G-C rich and contains consensus binding sites for Sp1 and AP-1. While FPP had no significant effect on the AP-1 DNA binding activity, the Sp1 DNA binding activity was significantly upregulated in PBMC after treatment of the cells with FPP. Innovation: This work provided first evidence that compromised respiratory burst performance of T2DM PBMC may be corrected by a nutritional supplement. Conclusion: FPP can correct respiratory burst performance of T2DM PBMC via an Sp-1-dependant pathway. Studies testing the outcome of FPP supplementation in diabetic patients are warranted. Antioxid. Redox Signal. 17, 485-491.

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“…Normal erythrocyte function depends on integrity of the erythrocyte membrane, which is a target for numerous toxic prooxidant factors, including chronic hyperglycemia (22,30). Erythrocyte membrane is among the main targets for oxygen radicals or peroxides as it contains both polyunsaturated fatty acids (PUFA), which are the most susceptible substrate for lipid peroxidation as well as prooxidant catalysts such as Fe 2+ and hemoproteins (23,33).…”

Section: Discussionmentioning

confidence: 99%

Correlation between erythropoietin serum levels and erythrocyte susceptibility to lipid peroxidation in elderly with type 2 diabetes

Grădinaru

Margină

Ilie

et al. 2015

Acta Physiologica Hungarica

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Erythropoietin (EPO), a key hormone involved in red blood cell formation has been recently acknowledged for its pleiotropic actions and protective role in ageing and various pathological conditions concurrent with oxidative stress, vascular diseases and metabolic abnormalities such as diabetes mellitus. The aim of the study was to evaluate the relationship between circulating erythropoietin levels and oxidative stress biomarkers, in elderly with type 2 diabetes (T2DM). The study was carried out in 67 subjects with T2DM (69 ± 5 years; n = 37) without anemia, and aged-matched controls (70 ± 6 years; n = 30). EPO serum levels, erythrocyte susceptibility to lipid peroxidation (ESP) and total antioxidant capacity (TAC) were evaluated. Lower EPO levels (p < 0.01) and higher ESP values (p < 0.001) were found in T2DM group, compared to healthy subjects. EPO levels showed significant negative associations with ESP, both in T2DM subjects (r = -0.565; p < 0.001) and in all study population (r = -0,600; p < 0,001; n = 67). In conclusion, we provide new data regarding the cytoprotective effect of EPO exerted at systemic level on erythrocyte membrane, in the particular state of impaired glucose metabolism associated with oxidative stress, in the elderly.

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Relationship Between Aging and Susceptibility of Erythrocytes to Oxidative Damage: In View of Nutraceutical Interventions

Cited by 21 publications

References 14 publications

Nutritive effect of cabbage (<i>Brassica oleracea</i>) on growth, obesity, lipidaemia and haematology in broiler and pullet chickens

Nutritive effect of cabbage (<i>Brassica oleracea</i>) on growth, obesity, lipidaemia and haematology in broiler and pullet chickens

Correction of Aberrant NADPH Oxidase Activity in Blood-Derived Mononuclear Cells from Type II Diabetes Mellitus Patients by a Naturally Fermented Papaya Preparation

Correlation between erythropoietin serum levels and erythrocyte susceptibility to lipid peroxidation in elderly with type 2 diabetes

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