Relationship between allergic rhinitis and allergic  conjunctivitis (allergic rhinoconjunctivitis) - review

Iordache, Mihaela; Borugă, Mădălina; Mușat, Ovidiu; Jipa, Daniel; Tătaru, Călin Petru; Muşat, Gabriela

doi:10.22336/rjo.2022.3

Cited by 11 publications

(7 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is presumably due to the shared properties of the conjunctiva and nasal mucosa — they have the same type of epithelial cells, they show similar allergen reactivity, and both play a role in Immunoglobulin E (IgE)-mediated allergic inflammation, indicating shared pathological mechanisms. Plus, the presence of an anatomical link between the eyes and nasal mucosa through the nasolacrimal duct enables allergic reactions to spread from the conjunctiva to the nose ( 6 ).…”

Section: Discussionmentioning

confidence: 99%

The Spectrum and Age-Sex Patterns Among Outpatients with Allergic Diseases — Yichang City, Hubei Province, China, 2018–2021

Wang¹,

Sun²,

Li³

et al. 2023

China CDC Weekly

View full text Add to dashboard Cite

What is already known about this topic? Allergic diseases have affected an estimated 40% of the population in China. However, our understanding of the full spectrum of these diseases remains insufficient. What is added by this report? Between 2018 and 2021, Yichang City documented 625,929 outpatient visits mainly related to skin and mucous membrane allergies (77.90%) and allergic respiratory conditions (19.64%). In 2021, the occurrence of outpatient visits for conditions such as allergic rhinitis, acute atopic conjunctivitis, and atopic dermatitis increased. The demographic analysis revealed that male patients comprised the majority of the under 18 age bracket (56.05%), while female patients were predominantly represented in the 18 to 65 age bracket (61.79%). What are the implications for public health practice? This constitutes the first analysis of the spectrum of allergic diseases, utilizing regional outpatient data, which has substantial implications for understanding the disease burden.

show abstract

Section: Discussionmentioning

confidence: 99%

The Spectrum and Age-Sex Patterns Among Outpatients with Allergic Diseases — Yichang City, Hubei Province, China, 2018–2021

Wang¹,

Sun²,

Li³

et al. 2023

China CDC Weekly

View full text Add to dashboard Cite

show abstract

“…Few incidences of benign conjunctivitis typically occur in the majority of patients with ocular allergies. The patient's examinations must include a thorough ocular inspection, biomicroscopy, a Slit-lamp biomicroscopic examination, and additional supplemental diagnostic procedures like an aeroallergen skin probe test [13][14][15] . Even though there are several different types of ocular allergies, perennial and seasonal AC is the mildest and the most prevalent one.…”

Section: Seasonal and Perennial Allergic Conjunctivitismentioning

confidence: 99%

Development in therapeutic strategies for allergic conjunctivitis

Singh,

Mazumder,

Monika

et al. 2023

Trends Immunother

View full text Add to dashboard Cite

Conjunctivitis, also known as pink eye, is a conjunctival inflammation. It is brought on by bacteria, viruses, toxins, and allergies, including coronaviruses, the most frequent reason being allergic conjunctivitis (AC), which is brought on by exposure to pollutants like pollen, animal hair, or mold. The primary contributor to it is the linkage of immunoglobulin E caused by allergens and receptors on stimulated conjunctival mast cells. As a consequence, mast cells are degranulated, along with the release of histamine, cytokines, chemokines, and lipid mediators. The particular eye tissues impacted and the immune mechanism(s) (both local and systemic) that are involved all play a role in the clinical course, length, intensity, and co-morbidities. It frequently occurs in conjunction with allergic rhinitis, also known as allergic rhino-conjunctivitis and other allergy conditions. Atopic keratoconjunctivitis, giant papillary conjunctivitis, seasonal and perennial conjunctivitis, and vernal keratoconjunctivitis are the different types of allergic conjunctivitis. Ocular allergies are frequently misdiagnosed and undertreated, despite the emergence of innovative therapeutic strategies. This review focuses on several previously published studies to discuss the available therapeutic options for treating allergic conjunctivitis as well as the potential targets for the therapies. The association of conjunctivitis with COVID-19, along with recent patents and research, has also been explored.

show abstract

“…Studies have previously demonstrated that the occurrence of AR in adults in China has risen significantly, with the prevalence increasing from 11.1% to 17.6% ( 7 ). AR is often accompanied by other health conditions like asthma and allergic conjunctivitis ( 8 , 9 ). Indeed, research has indicated that clinical asthma is present in 20% to 50% of individuals with AR, while over 80% of patients diagnosed with allergic asthma also experience symptoms of rhinitis simultaneously ( 10 ).…”

Section: Introductionmentioning

confidence: 99%

Identification of diagnostic signature, molecular subtypes, and potential drugs in allergic rhinitis based on an inflammatory response gene set

Dai,

Xia,

Huai

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

BackgroundRhinitis is a complex condition characterized by various subtypes, including allergic rhinitis (AR), which involves inflammatory reactions. The objective of this research was to identify crucial genes associated with inflammatory response that are relevant for the treatment and diagnosis of AR.MethodsWe acquired the AR-related expression datasets (GSE75011 and GSE50223) from the Gene Expression Omnibus (GEO) database. In GSE75011, we compared the gene expression profiles between the HC and AR groups and identified differentially expressed genes (DEGs). By intersecting these DEGs with inflammatory response-related genes (IRGGs), resulting in the identification of differentially expressed inflammatory response-related genes (DIRRGs). Afterwards, we utilized the protein–protein interaction (PPI) network, machine learning algorithms, namely least absolute shrinkage and selection operator (LASSO) regression and random forest, to identify the signature markers. We employed a nomogram to evaluate the diagnostic effectiveness of the method, which has been confirmed through validation using GSE50223. qRT-PCR was used to confirm the expression of diagnostic genes in clinical samples. In addition, a consensus clustering method was employed to categorize patients with AR. Subsequently, extensive investigation was conducted to explore the discrepancies in gene expression, enriched functions and pathways, as well as potential therapeutic drugs among these distinct subtypes.ResultsA total of 22 DIRRGs were acquired, which participated in pathways including chemokine and TNF signaling pathway. Additionally, machine learning algorithms identified NFKBIA, HIF1A, MYC, and CCRL2 as signature genes associated with AR’s inflammatory response, indicating their potential as AR biomarkers. The nomogram based on feature genes could offer clinical benefits to AR patients. We discovered two molecular subtypes, C1 and C2, and observed that the C2 subtype exhibited activation of immune- and inflammation-related pathways.ConclusionsNFKBIA, HIF1A, MYC, and CCRL2 are the key genes involved in the inflammatory response and have the strongest association with the advancement of disease in AR. The proposed molecular subgroups could provide fresh insights for personalized treatment of AR.

show abstract

Relationship between allergic rhinitis and allergic conjunctivitis (allergic rhinoconjunctivitis) - review

Abstract: This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Cited by 11 publications

References 38 publications

The Spectrum and Age-Sex Patterns Among Outpatients with Allergic Diseases — Yichang City, Hubei Province, China, 2018–2021

The Spectrum and Age-Sex Patterns Among Outpatients with Allergic Diseases — Yichang City, Hubei Province, China, 2018–2021

Development in therapeutic strategies for allergic conjunctivitis

Identification of diagnostic signature, molecular subtypes, and potential drugs in allergic rhinitis based on an inflammatory response gene set

Contact Info

Product

Resources

About