Relationship between anemia and biochemical parameters of mineral bone disorders in chronic kidney disease patients

Abstract

Background: Anemia, electrolyte disturbances and mineral bone disorders are common outcomes of chronic kidney disease (CKD). Aim of the work: To asses' relationship between anemia and mineral bone disorder (MBD) parameters in stages 3-5 CKD on conservative treatment patients. Patients and Methods:The current study included a sample of ( 160) cases, all of whom had chronic kidney disease All subjects were submitted to full history, clinical examination, and laboratory testing which included complete blood count, Calcium, Phosphorus and Parathyroid hormone (PTH). Quantitative determination of total 25-OH Vitamin D was measured in all patients. Estimated glomerular filtration rate (eGFR) was being calculated. Result:The study revealed a statistically significant association between Hb and eGFR, and also showed a statistically significant negative relationship (p value = 0.001) (r = -0.38) between Hb and serum creatinine. It also revealed a semi-inverse relationship between serum parathormone (iPTH) and hemoglobin level in blood between CKD. Whenever there is an increase in the serum iPTH reflects the decrease in the level of hemoglobin in the blood of the study sample of patients with chronic kidney disease. One of the important statistical results indicated by the study is that blood phosphate is linked to low hemoglobin in kidney patients. Our study agreed with studies that show that vitamin D deficiency is closely related to low hemoglobin level in CKD patients.The lower the calcium level, the lower the hemoglobin level. We found that increased blood calcium is associated with a higher hemoglobin level. Conclusion:Our study showed the significant association between CKD-BMD and anemia. It also showed that increased serum phosphate, parathyroid activity, severe deficiency in vitamin D and a high incidence of anemia among patients with chronic kidney disease.