Relationship Between Angiotensin- Converting Enzyme Gene Polymorphism (Insertion/Deletion) and the Clinical Condition of Sepsis in Turkish Children

Ethnic and age-specific acute lung injury/acute respiratory distress syndrome risk associated with angiotensin-converting enzyme insertion/deletion polymorphisms, implications for COVID-19: A meta-analysis

“…1 ; the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines ( Moher et al, 2009 ), a checklist of which is detailed in Table S2 was followed for this study. The initial search resulted in 355 citations retrieved, followed by a series of omissions that eventually yielded 16 articles for inclusion ( Adamzik et al, 2007 ; Cardinal-Fernandez et al, 2013 ; Çelik et al, 2010 ; Chan et al, 2005 ; Cruces et al, 2012 ; Jerng et al, 2006 ; Lu et al, 2016 ; Lu et al, 2011 ; Marshall et al, 2002a ; Plunkett et al, 2008 ; Salnikova et al, 2013 ; Satar et al, 2012 ; Sivasli et al, 2007 ; Tsantes et al, 2013 ; Villar et al, 2008 ; Yimenicioglu et al, 2011 ). Eleven articles presented multiple datasets resulting in a total of 13, 7 and 9 studies for A1, A2 and A3, respectively (Table S3).…”

“…Based on these quantitative characteristics, the quality of the component studies was moderate. Control frequencies in four studies from three articles ( Çelik et al, 2010 ; Lu et al, 2011 ; Yimenicioglu et al, 2011 ) deviated from HWE (Table S3).

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Association between angiotensin-converting enzyme I/D polymorphism and sepsis: A meta-analysis

“…After discarding overlapping references and those that clearly did not meet the criteria, a total of six case-control studies and two cohort studies were included in this meta-analysis. [11][12][13][14][15][16][17][18] All studies were performed in a Caucasian population. There were five studies of a pediatric population [11][12][13]15,17 and three studies of an adult population.…”

“…[11][12][13][14][15][16][17][18] All studies were performed in a Caucasian population. There were five studies of a pediatric population [11][12][13]15,17 and three studies of an adult population. 14,16,18 Five case-control studies indicated that the distribution of genotypes in the controls was consistent with HWE.…”

“…To date, several studies have investigated the association of ACE I/D polymorphism with sepsis. [11][12][13][14][15][16][17][18] However, the results of these studies were inconsistent, possibly due to the insufficient sample size. Meta-analysis is a statistical procedure for combining results from published studies, in order to acquire a precise estimation of the major effect.…”