Relationship between antifungal activity and hydrophobicity of kojic acid derivatives

Baláž, Štefan; Uher, Μ.; Brtko, Július; Veverka, Miroslav; Bransova, J.; Dobiáš, J.; Pódová, M.; Buchvald, J

doi:10.1007/bf02898762

Cited by 24 publications

(5 citation statements)

References 6 publications

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“…The antimicrobial activity of KA and its derivatives against a number of microorganisms was reported previously; 29,45,48,62,63 there are no similar reports in the literature for KA nanocomposites. Incorporating other derivatives of KA of higher antibacterial activity may also reveal additional information towards understanding the antimicrobial activity of KA-polymer-nanocomposites and their applications.…”

Section: In Vitro Antimicrobial Activity Of the Ka Nanocompositesmentioning

confidence: 76%

Novel kojic acid-polymer-based magnetic nanocomposites for medical applications

Hussein‐Al‐Ali¹,

Zowalaty²,

Hussein³

et al. 2014

IJN

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Iron oxide magnetic nanoparticles (MNPs) were synthesized by the coprecipitation of iron salts in sodium hydroxide followed by coating separately with chitosan (CS) and polyethylene glycol (PEG) to form CS-MNPs and PEG-MNPs nanoparticles, respectively. They were then loaded with kojic acid (KA), a pharmacologically bioactive natural compound, to form KA-CS-MNPs and KA-PEG-MNPs nanocomposites, respectively. The MNPs and their nanocomposites were characterized using powder X-ray diffraction, Fourier transform infrared spectroscopy, thermogravimetric analysis, vibrating sample magnetometry, and scanning electron microscopy. The powder X-ray diffraction data suggest that all formulations consisted of highly crystalline, pure magnetite Fe 3 O 4 . The Fourier transform infrared spectroscopy and thermogravimetric analysis confirmed the presence of both polymers and KA in the nanocomposites. Magnetization curves showed that both nanocomposites (KA-CS-MNPs and KA-PEG-MNPs) were superparamagnetic with saturation magnetizations of 8.1 emu/g and 26.4 emu/g, respectively. The KA drug loading was estimated using ultraviolet–visible spectroscopy, which gave a loading of 12.2% and 8.3% for the KA-CS-MNPs and KA-PEG-MNPs nanocomposites, respectively. The release profile of the KA from the nanocomposites followed a pseudo second-order kinetic model. The agar diffusion test was performed to evaluate the antimicrobial activity for both KA-CS-MNPs and KA-PEG-MNPs nanocomposites against a number of microorganisms using two Gram-positive (methicillin-resistant Staphylococcus aureus and Bacillus subtilis ) and one Gram-negative ( Salmonella enterica ) species, and showed some antibacterial activity, which could be enhanced in future studies by optimizing drug loading. This study provided evidence for the promise for the further investigation of the possible beneficial biological activities of KA and both KA-CS-MNPs and KA-PEG-MNPs nanocomposites in nanopharmaceutical applications.

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Section: In Vitro Antimicrobial Activity Of the Ka Nanocompositesmentioning

confidence: 76%

Novel kojic acid-polymer-based magnetic nanocomposites for medical applications

Hussein‐Al‐Ali¹,

Zowalaty²,

Hussein³

et al. 2014

IJN

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“…35 Kojic acid was tested in the agar diffusion test against twenty five dermatophytic fungi. 36 The kojic acid has efficiency of whitening, antioxidant and antibacterial. Content of total phenol with antioxidant and antibacterial were relevant.…”

Section: Determination Of Total Phenolic and Kojic Acid Contentmentioning

confidence: 99%

Antioxidant properties and antibacterial activity of fermented Monascus purpureus extracts

Lin¹,

Hur²,

Lin³

2019

MOJFPT

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Monascus rice ferment extracts has anti-oxidant and antibiotic efficiency. Oxidative stress contributes to skin aging and can adversely affect skin health, which means antioxidants active in skin cells may support skin health. Antioxidant can contribute to defending old. Suppress the production that the epidermis bacterium can reduce the whelk and comedo. Our objective to evaluate the antioxidant properties, antibacterial activity and protective effects on UV-induced damage in HaCaT keratinocytes of extra different carbon and nitrogen sources at water (MRW) and methanolic (MRM) extracts from Monascus purpureus BCRC 31615 fermented rice. Effectiveness in reducing powers and DPPH radical scavenging ability was Monascus rice add MSG water extract has prominent ability. The ferment rice added nitrogen source to increase total phenols and kojic acid content. Antibacterial activities showed good in inhibition Staphylococcus aureus BCRC 10780. Protective effects on UV-induced damage in HaCaT keratinocytes which M. purpureus ferment rice added with extra nitrogen source was especially potent in inhibited UV-induced keratinocyte death.

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“…The higher cytotoxic activity of methoxyvermistatin, as measured against KB and KBv200 cells (derived from epithelial carcinoma) [ 21 ], also indicates that a remarkable importance pertains to the methoxyl group at the γ-pyrone ring, which also characterizes 3-O-methylfunicone. To this regard, it must be considered that the antifungal activity reported for several derivatives of kojic acid [ 43 ] provides a further indirect evidence that biological properties of funicone-related compounds are in part dependent on the γ-pyrone moiety.…”

Section: Biological Activities Of Funicone-related Compoundsmentioning

confidence: 99%

Occurence and Bioactivities of Funicone-Related Compounds

Nicoletti¹,

Manzo

Ciavatta

2009

IJMS

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Studies on production of secondary metabolites by fungi have received a substantial boost lately, particularly with reference to applications of their biological properties in human medicine. Funicones represent a series of related compounds for which there is accumulating evidence supporting their possible use as pharmaceuticals. This paper provides a review on the current status of knowledge on these fungal extrolites, with special reference to aspects concerning their molecular structures and biological activities.

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Relationship between antifungal activity and hydrophobicity of kojic acid derivatives

Cited by 24 publications

References 6 publications

Novel kojic acid-polymer-based magnetic nanocomposites for medical applications

Novel kojic acid-polymer-based magnetic nanocomposites for medical applications

Antioxidant properties and antibacterial activity of fermented Monascus purpureus extracts

Occurence and Bioactivities of Funicone-Related Compounds

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