Relationship between antithrombotic activities of fucans and their structure

Abstract

A low molecular weight fucan fraction extracted from the brown seaweed Ascophyllum nodosum was previously shown to exhibit dose-related venous antithrombotic activity with an ED 80 of about 20 mg/kg, 2 h after a single subcutaneous injection HCII Thromb Res 64:143-154; Mauray et al. [1995] Thromb Haemast 74:1280-1285). Its activity was comparable to that of a low molecular weight heparin (Dalteparin ® ). This fucan fraction is one of several, with a range of different structure parameters, prepared by degradation of the whole native fucan. These low molecular weight fractions were compared using a Wessler stasis thrombosis model in rabbits and by determination of their in vitro and ex vivo anticoagulant activities. Intravenous administrations of these fractions reduced thrombosis in a dose-dependent manner. Partial removal of sulfate groups and/or partial degradation lead to a significant decrease in their anticoagulant and antithrombotic activities. The integrity of the regular pattern of sulphation of the fucoidan is necessary for antithrombotic activity. Drug Dev. Res. 51:216-224, 2000.

Fucoidan Modulates the Effect of Transforming Growth Factor (TGF)-.BETA.1 on Fibroblast Proliferation and Wound Repopulation in in Vitro Models of Dermal Wound Repair

“…8,29) Initial interest focused on the anti-coagulant activity with the aim of identifying a non-animal alternative to heparin (see refs. [30][31][32][33][34]. However, as well as their anticoagulant activity, fucoidans have also been shown to interact and modulate the activities of a range of growth factors and cytokines through mechanisms which are thought to be similar to those of glycosaminoglycans such as heparin and chondroitin sulphate.…”

Prospects for the therapeutic application of sulfated polysaccharides of brown algae in diseases of the cardiovascular system: review

“…Brown-algal fucoidans possess a broad spectrum of biological activities, including anti-coagulant (Cumashi et al 2007), hypolipidemic (Yokota et al 2009;Cuong et al 2015), anti-thrombotic (Boisson-Vidal et al 2000;Mourao 2004;Drozd et al 2011), anti-inflammatory (Cl ement et al 2010Marques et al 2012;Pomin 2015), immunomodulatory , anti-adhesive (Cumashi et al 2007) and anti-hypertensive properties (Xueyan et al 2004); these molecules may exert an influence on numerous targets in the context of atherosclerosis therapy.…”

“…Disturbances in hemostasis progress via the participation of blood-clotting factor VII, factor X and its active form Xa and factor V. The anti-coagulant and antithrombotic properties of fucoidan are among the most important properties of its biological activity. Numerous studies and reviews have described these properties (Boisson-Vidal et al 2000;Mourao 2004;Matsubara et al 2005). The effect of the fucoidans on blood coagulation and platelets aggregation depends on their structural features.…”

“…Exogenous polysaccharides with a heparin-like structure influence angiogenesis via the competitive inhibition of HSPG (Chabut et al 2003). In this regard, promising studies have been conducted on fucoidan as an inducer of angiogenesis and vasculogenesis (Boisson-Vidal et al 2000;Chabut et al 2003Chabut et al , 2004. It should be noted that the effect of fucoidan on angiogenesis varies, depending on the source it was derived from, its molecular weight and the degree of sulfation (Ustyuzhanina et al 2014).…”

“…Fucoidans possess a broad spectrum of biological activity (Fitton 2011), including anti-coagulant (Cumashi et al 2007;Ustyuzhanina et al 2013), hypolipidemic (Yokota et al 2009;Cuong et al 2015), antithrombotic (Boisson-Vidal et al 2000;Mourao 2004;Drozd et al 2011), anti-inflammatory (Cl ement et al 2010Marques et al 2012;Pomin 2015), immunomodulatory Zhang et al, 2015b), anti-tumor, anti-bacterial, anti-viral (Berteau & Mulloy 2003), anti-adhesive (Cumashi et al 2007) and anti-hypertensive properties (Xueyan et al 2004); this allows them to consider as polyvalent biomodulators. The pleiotropic action of fucoidans is associated with structural features.…”