Relationship between asthma and IL-17 gene polymorphism in a Turkish population

Yüce, Gülbahar Darılmaz; Erdoğan, Tuba; Bozkurt, Bülent; TOPRAK>, Uğur; Ceylan, Gülay Güleç

doi:10.1007/s11845-022-02956-5

Cited by 5 publications

(5 citation statements)

References 23 publications

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“…Ten studies were excluded because they did not include IL17 polymorphisms or asthma. Twenty studies met the inclusion criteria (Figure 2, Table 1) (Amal et al., 2022; Bazzi et al., 2011; Chen et al., 2010; Du et al., 2016; Holster et al., 2018; Jin et al., 2011; Kawaguchi et al., 2006; Kohyama et al., 2011; Liang et al., 2018; Maalmi et al., 2014; Narbutt et al., 2015; Qian et al., 2012; Raeiszadeh Jahromi et al., 2015; Ramsey et al., 2005; Schieck et al., 2014; Shaban et al., 2021; WANG, 2011; Wang et al., 2009; Yuce et al., 2022; Zhong et al., 2016). One of the eligible studies contained data from two groups treated independently (Wang et al., 2009).…”

Section: Resultsmentioning

confidence: 99%

“…However, since the last reported meta‐analysis, more studies have been conducted. Although some researchers have identified a relationship between these polymorphisms and asthma, others have not (Amal et al., 2022; Bazzi et al., 2011; Chen et al., 2010; Du et al., 2016; Holster et al., 2018; Jin et al., 2011; Kawaguchi et al., 2006; Kohyama et al., 2011; Liang et al., 2018; Maalmi et al., 2014; Narbutt et al., 2015; Qian et al., 2012; Raeiszadeh Jahromi et al., 2015; Ramsey et al., 2005; Schieck et al., 2014; Shaban et al., 2021; WANG, 2011; Wang et al., 2009; Yuce et al., 2022; Zhong et al., 2016); these discrepancies may arise from small sample sizes, poor statistical analyses and/or clinical heterogeneity. We performed a meta‐analysis to overcome the limitations of individual studies, explain conflicts and reduce the likelihood of false‐positive or false‐negative associations being produced by random errors (Lee, 2018; Lee et al., 2011; Lee & Song, 2020).…”

Section: Introductionmentioning

confidence: 99%

“…Although some researchers have identified a relationship between these polymorphisms and asthma, others have not (Amal et al, 2022;Bazzi et al, 2011;Chen et al, 2010;Du et al, 2016;Holster et al, 2018;Jin et al, 2011;Kawaguchi et al, 2006;Kohyama et al, 2011;Liang et al, 2018;Maalmi et al, 2014;Narbutt et al, 2015;Qian et al, 2012;Raeiszadeh Jahromi et al, 2015;Ramsey et al, 2005;Schieck et al, 2014;Shaban et al, 2021;WANG, 2011;Wang et al, 2009;Yuce et al, 2022;Zhong et al, 2016); these discrepancies may arise from small sample sizes, poor statistical analyses and/or clinical heterogeneity.…”

Section: Introductionmentioning

confidence: 99%

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Associations between interleukin 17A and 17F polymorphisms and asthma susceptibility: A meta‐analysis

Lee

Song

2023

Int J Immunogenetics

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Owing to their role in inflammatory reactions and immunological responses as well as their chromosomal location, interleukin (IL) 17A and 17F are regarded as candidate causal genes associated with asthma. The aim of this study was to determine whether IL17 polymorphisms are associated with susceptibility to asthma. We used the PubMed/Medline and Embase databases to search for studies reporting IL17 polymorphisms in patients with asthma and healthy controls. Meta-analyses were conducted to determine the associations between IL17A rs8193036 (−737C/T), rs2275913 (−197G/A), rs3819024 (A/G), rs3748067 (C/T), and rs4711998 (A/G) and IL17F rs763780 (7488A/G), rs2397084 (T/C), rs1889570 (C/T), rs11465553 (G/A), and rs1266828 (T/C) polymorphisms and asthma susceptibility. A total of 20 studies were included in this meta-analysis. Our results revealed the IL17A rs8193036 CC genotype was associated with asthma susceptibility (odds ratio [OR] = 1.490, 95% confidence interval [CI] = 1.027-2.161, p = .036). However, stratification by ethnicity indicated no association between this polymorphism and asthma in European and Asian subjects. Furthermore, no association was found between this polymorphism and asthma using the allele contrast, dominant or homozygous contrast models. No evidence of an association was found between any of the other IL17A and IL17F polymorphisms and asthma susceptibility in this meta-analysis. This meta-analysis showed that, among the studied polymorphisms, only the CC genotype of IL17A rs8193036 is associated with asthma susceptibility.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Associations between interleukin 17A and 17F polymorphisms and asthma susceptibility: A meta‐analysis

Lee

Song

2023

Int J Immunogenetics

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“…At the same time, the mRNA expression level of IL-17A can also be used to evaluate the susceptibility to asthma. Measuring the mRNA expression level of IL-17A in the peripheral blood or airway of patients, can help to judge the susceptibility and prognosis of asthma (9). It can be seen that the genetic variation and mRNA expression level of IL-17A may be used as an auxiliary index to evaluate asthma susceptibility.…”

Section: Discussionmentioning

confidence: 99%

The effect of genetic variation and mRNA expression of interleukin-17A gene on susceptibility to asthma

Xuejiao Han,

Fei Jin,

Honghong Liu

et al. 2023

Cell Mol Biol (Noisy-le-grand)

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“…Although several SNPs related to IL-17A have been linked to susceptibility of a variety of immune-mediated/inflammatory disorders [ 38 , 39 , 40 , 41 , 42 , 43 , 44 ], including asthma [ 45 , 46 , 47 , 48 , 49 ], with potential modification of related gene expression and Th17 cells activities [ 40 , 50 ], no previous studies have explored the potential role of IL17RA gene variants in asthma susceptibility, in particular in our population. In this sense, the current study was designed to investigate for the first time the association between four SNPs (i.e., rs4819554, rs879577, rs41323645, and rs4819555) in IL-17RA and asthma susceptibility/phenotype in our region.…”

Section: Introductionmentioning

confidence: 99%

Impact of Interleukin-17 Receptor A Gene Variants on Asthma Susceptibility and Clinical Manifestations in Children and Adolescents

Maher,

AbdAllah,

Ageeli

et al. 2024

Children

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Several single nucleotide polymorphisms (SNPs) in multiple interleukin receptor genes could be associated with asthma risk and/or phenotype. Interleukin-17 (IL-17) has been implicated in tissue inflammation and autoimmune diseases. As no previous studies have uncovered the potential role of IL17 receptor A (RA) gene variants in asthma risk, we aimed to explore the association of four IL17RA SNPs (i.e., rs4819554A/G, rs879577C/T, rs41323645G/A, and rs4819555C/T) with asthma susceptibility/phenotype in our region. TaqMan allelic discrimination analysis was used to genotype 192 individuals. We found that the rs4819554 G/G genotype significantly reduced disease risk in the codominant (OR = 0.15, 95%CI = 0.05–0.45, p < 0.001), dominant (OR = 0.49, 95%CI = 0.26–0.93, p = 0.028), and recessive (OR = 0.18, 95%CI = 0.07–0.52, p < 0.001) models. Similarly, rs879577 showed reduced disease risk associated with the T allele across all genetic models. However, the A allele of rs41323645 was associated with increased disease risk in all models. The G/A and A/A genotypes have higher ORs of 2.47 (95%CI = 1.19–5.14) and 3.86 (95%CI = 1.62–9.18), respectively. Similar trends are observed in the dominant 2.89 (95%CI = 1.47–5.68, p = 0.002) and recessive 2.34 (95%CI = 1.10–4.98, p = 0.025) models. For the rs4819555 variant, although there was no significant association identified under any models, carriers of the rs4819554*A demonstrated an association with a positive family history of asthma (71.4% in carriers vs. 27% in non-carriers; p = 0.025) and the use of relievers for >2 weeks (52.2% of carriers vs. 28.8% of non-carriers; p = 0.047). Meanwhile, the rs4819555*C carriers displayed a significant divergence in the asthma phenotype, specifically atopic asthma (83.3% vs. 61.1%; p = 0.007), showed a higher prevalence of chest tightness (88.9% vs. 61.5%; p = 0.029), and were more likely to report comorbidities (57.7% vs. 16.7%, p = 0.003). The most frequent haplotype in the asthma group was ACAC, with a frequency of 22.87% vs. 1.36% in the controls (p < 0.001). In conclusion, the studied IL17RA variants could be essential in asthma susceptibility and phenotype in children and adolescents.

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Relationship between asthma and IL-17 gene polymorphism in a Turkish population

Cited by 5 publications

References 23 publications

Associations between interleukin 17A and 17F polymorphisms and asthma susceptibility: A meta‐analysis

Associations between interleukin 17A and 17F polymorphisms and asthma susceptibility: A meta‐analysis

The effect of genetic variation and mRNA expression of interleukin-17A gene on susceptibility to asthma

Impact of Interleukin-17 Receptor A Gene Variants on Asthma Susceptibility and Clinical Manifestations in Children and Adolescents

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