Relationship between autoimmune thyroid disease and nephropathy

Zhao, Liping; Liu, Yunxiao; Su, Hongchang; Shi, Xiangzhen

doi:10.1097/md.0000000000026273

Cited by 4 publications

(3 citation statements)

References 29 publications

(52 reference statements)

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“…The observed frequency of CKD patients with concurrent autoimmune thyroid disease in this study 14/184 (7.6%) for Tg-Abs and 29/184 (15.8%) for TPO-Abs are partially close to 82/1032 (7.9%) for Tg-Abs and TPO-Abs reported in a retrospective study in China [ 22 ]. The CKD patients with concurrent autoimmune thyroid disease had higher levels of membranous nephropathy and focal segmental glomerulosclerosis, reduced mesangial proliferative glomerulonephritis compared with CKD patients without autoimmune thyroid disease [ 22 ]. Autoimmune thyroid disease has been associated with hyperthyroidism and hypothyroidism.…”

Section: Discussionsupporting

confidence: 82%

Spectrum of Thyroid Dysfunction in Patients with Chronic Kidney Disease in Benin City, Nigeria

Obasuyi

Emokpae

2023

Medicines

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There is an indication of abrupt rise in chronic kidney disease (CKD) in Nigeria and thyroid function involvement has not been sufficiently evaluated. This study determined thyroid gland function among subjects with CKD in Benin City, Nigeria. A total of 184 randomized CKD patients attending specialist clinic and 80 healthy control subjects were recruited for this study. A well-structured questionnaire was used to obtain data on socio-demography. Blood specimens were collected and used for the determination of thyroid function parameters; thyroid stimulating hormone (TSH), triiodothyronine (T3), free triiodothyronine (fT3), thyroxine (T4), free thyroxine (fT4), thyroid peroxidase antibody (TPO-Abs), thyroid globulin antibody (Tg-Abs) and Deiodinase enzyme Type 1 (D1). SPINA GD and SPINA GT were calculated using Michaelis-Menten model. The CKD was classified into stages using Modification of Drug in Renal Disease (MDRD) formula. Thyroid dysfunctions observed were clinical hyperthyroidism 1 (0.54%), non-thyroidal illness 78 (42.4%), clinical hypothyroidism 11 (6.0%), sub-clinical hyperthyroidism 3 (1.60%), and sub-clinical hypothyroidism 11 (6.0%), while euthyroid were 80 (43.5%). SPINA GD of CKD patients (33.85 ± 10.94) was not significantly different when compared with controls (24.85 ± 1.57), whereas, SPINA GT was significantly higher (p < 0.01) among CKD patients (3.74 ± 0.31) than controls (2.68 ± 0.11). Autoimmune thyroid disease demonstrated by positive Tg-Abs and TPO-Abs were observed among approximately 7.9% of CKD patients. Serum TPO-Abs concentration increased with CKD progression. Thyroid dysfunction is involved in the pathogenesis of CKD patients. The etiologies are multifactorial and immunological mechanisms of autoimmune thyroid disease may be a contributing factor.

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Section: Discussionsupporting

confidence: 82%

Spectrum of Thyroid Dysfunction in Patients with Chronic Kidney Disease in Benin City, Nigeria

Obasuyi

Emokpae

2023

Medicines

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“…Наслідки для здоров'я, зокрема якості й тривалості життя хворих на АІТ і автоімунну нефропатію, досить серйозні. Тому моніторинг функції нирок є складовою спостереження за пацієнтами з АІТ, особливо з гіпотиреозом [90].…”

Section: патогенетичні механізми клінічні ознаки і наслідки впливу ав...unclassified

Pathogenetic mechanisms, clinical signs and consequences of the autoimmune thyroiditis impact on body systems (a literature review)

Shidlovskyi

Shidlovskyі

Шеремет

et al. 2022

Mìžnarodnij endokrinologìčnij žurnal

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Background. The review analyzes the publications on the pathogenetic mechanisms and clinical consequences of the impact of autoimmune thyroiditis and hypothyroidism on body systems. Autoimmune thyroiditis is an organ-specific autoimmune disease of the thyroid gland and the most common cause of hypothyroidism in regions of the world with sufficient iodine. Sources of information. The sources of information were reports in domestic and, mostly, foreign periodicals on immunology, pathological physiology, internal medicine, and endocrinology. Synthesis of evidence. The effect of autoimmune thyroiditis on the systems of the body is implemented in two ways. The first one is accomplished through the body’s immune system, when the organ-specific immune process in the thyroid gland for unknown reasons acquires signs of systemic disease with clinical manifestations of damage to other organs and systems. The second is due to hypothyroidism, which is the logical conclusion of the autoimmune process in the thyroid. The effects of hypothyroidism on the body as a whole and its systems, in particular, are known, and the pathogenetic mechanisms are not fully understood and require in-depth study. The issues of the body's autoimmune disease, the mechanisms of its initiation and progression remain undiscovered and poorly understood. Conclusions. The effect of autoimmune thyroiditis is realized through the immune system when the organ-specific immune process in the thyroid gland for unknown reasons acquires signs of systemic disease and hypothyroidism, which is the logical conclusion of the autoimmune process in the thyroid gland. The pathogenetic mechanisms of the effects of autoimmune thyroiditis and hypothyroidism on the body are not fully understood and require in-depth study. The presented data show that over the last decade the interest in studying the problem of autoimmune thyroiditis, hypothyroidism, and their pathological significance for the body has deepened.

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“…Autoimmune thyroiditis, a chronic autoimmune condition, is characterized by the constant disruption of thyroid gland function stemming from an attack by immune cells of the host on its own tissues. , As the disease progresses, it not only threatens health via potential complications such as membranous nephropathy, glomerulonephritis, and nephrotic syndrome but also heightens the risk of thyroid cancer. − In the unfortunate event that it develops into extremely rare anaplastic thyroid carcinoma, it could become even more life-threatening . However, the insidious onset and slow progression always make most patients remain asymptomatic, making the diseases undetected, in turn underscoring the necessity for efficacious diagnostic measures. , …”

Section: Introductionmentioning

confidence: 99%

A Pyroglutamate Aminopeptidase 1 Responsive Fluorescence Imaging Probe for Real-Time Rapid Differentiation between Thyroiditis and Thyroid Cancer

Zhang,

Ma,

et al. 2024

Anal. Chem.

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Current diagnostic methods for thyroid diseases, including blood tests, ultrasound, and biopsy, always have difficulty diagnosing thyroiditis accurately, occasionally mistaking it for thyroid cancer. To address this clinical challenge, we developed Ox-PGP1, a novel fluorescent probe realizing rapid, noninvasive, and real-time diagnostic techniques. This is the first imaging tool capable of noninvasively distinguishing between thyroiditis and thyroid cancer. Ox-PGP1 was introduced as a fluorescent probe custom-built for the specific detection and quantification of pyroglutamate aminopeptidase 1 (PGP-1), a known pivotal biomarker of inflammation. Ox-PGP1 overcame the disadvantages of traditional enzyme-responsive fluorescent probes that relied on the intramolecular charge transfer (ICT) mechanism, including the issue of high background fluorescence, while offering exceptional photostability under laser irradiation. The spectral properties of Ox-PGP1 were meticulously optimized to enhance its biocompatibility. Furthermore, the low limit of detection (LOD) of Ox-PGP1 was determined to be 0.09 μg/mL, which demonstrated its remarkable sensitivity and precision. Both cellular and in vivo experiments validated the capacity of Ox-PGP1 for accurate differentiation between normal, inflammatory, and cancerous thyroid cells. Furthermore, Ox-PGP1 showed the potential to rapidly and sensitively differentiate between autoimmune thyroiditis and anaplastic thyroid carcinoma in a mouse model, achieving results in just 5 min. The successful design and application of Ox-PGP1 represent a substantial advancement in technology over traditional diagnostic approaches, potentially enabling earlier interventions for thyroid diseases.

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Relationship between autoimmune thyroid disease and nephropathy

Cited by 4 publications

References 29 publications

Spectrum of Thyroid Dysfunction in Patients with Chronic Kidney Disease in Benin City, Nigeria

Spectrum of Thyroid Dysfunction in Patients with Chronic Kidney Disease in Benin City, Nigeria

Pathogenetic mechanisms, clinical signs and consequences of the autoimmune thyroiditis impact on body systems (a literature review)

A Pyroglutamate Aminopeptidase 1 Responsive Fluorescence Imaging Probe for Real-Time Rapid Differentiation between Thyroiditis and Thyroid Cancer

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