Relationship between Barrett’s esophagus and colonic diseases: a role for colonoscopy in Barrett’s surveillance

Amano, Yuji; Nakahara, Ryotaro; Yuki, Takafumi; Murakami, Daisuke; Ujihara, Tetsuro; Iwaki, Toru; Sagami, Ryota; Suehiro, Satoshi; Katsuyama, Yasushi; Hayasaka, Kenji; Harada, Hideaki; Tada, Yasumasa; Miyaoka, Youichi; Fujishiro, Hirofumi

doi:10.1007/s00535-019-01600-x

Cited by 5 publications

(8 citation statements)

References 55 publications

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“…Left‐sided CD is predominant in Western patients, 19,20 though individuals of African descent have a greater percentage of diverticula in the proximal colon and lower in the distal colon as compared with Caucasians 45 . In Asian countries, right‐sided CD is predominant as compared to the left‐sided or bilateral‐sided CD, suggesting ethnic differences, though cases of left‐sided and bilateral‐sided CD, more common in Western populations, have recently been increasing 18,21,30,46 . Therefore, the combination of right‐sided CD and distal colon cancer often seen in Asians may decrease in the near future.…”

Section: Discussionmentioning

confidence: 99%

“…In the present study, we also investigated upper gastrointestinal disorders as the clinical covariables for presence of early colon cancer. It has been well known that patients with gastric cancer frequently show synchronous or metachronous colon cancers, 47–49 and colon cancer and CD have been also reported to be the predictors of the presence of Barrett’s esophagus and reflux esophagitis 30 . On the other hand, Helicobacter pylori infection has showed an inverse correlation with the presence of CD 30 .…”

Section: Discussionmentioning

confidence: 99%

“…Adenomas were only diagnosed when >5 mm in diameter. CD was diagnosed when more than five diverticula were shown in endoscopic findings, with the location in the colon divided into right‐sided, left‐sided, and bilateral‐sided 30 . Colonoscopy was done with a transparent hood for all patients to prevent overlooking a minute lesion, including a small diverticulum.…”

Section: Methodsmentioning

confidence: 99%

“…CD was diagnosed when more than five diverticula were shown in endoscopic findings, with the location in the colon divided into right-sided, left-sided, and bilateral-sided. 30 Colonoscopy was done with a transparent hood for all patients to prevent overlooking a minute lesion, including a small diverticulum. Patients in a post-colectomy condition, with advanced colon cancer, as such a tumor can sometimes interfere with detection of CD, and without endoscopic records for sufficient evaluation were excluded.…”

Section: Methodsmentioning

confidence: 99%

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Relationship between colonic diverticulosis and colon neoplasms in Japanese patients

Nakahara

Amano

Murakami

et al. 2020

Digestive Endoscopy

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Background and Aim Colonic diverticulosis (CD) has been reported to be associated with presence of colon neoplasms (CNs) in Western patients, since most of the associated risk factors are common between them. However, such correlation has not been fully investigated in Asian patients. In this study, the association of CNs with CD was evaluated in a multicenter investigation. Methods We enrolled 5633 patients who underwent both colonoscopy and esophagogastroduodenoscopy due to annual follow‐up, screening for positive occult blood testing and abdominal symptoms between January 2016 and December 2017 at three institutions. The relationship between the presence of CNs and CD was investigated, and predictors for presence of CNs were determined by multivariate logistic analysis. Results The enrolled patients consisted of 1799 (31.9%) with CD (average age 70.0 years, male 64.0%) and 3834 without CD (66.0 years, male 52.9%), with the prevalence of CNs in those groups 46.6% and 44.2%, respectively (P = 0.090). Predictors for early colon cancer were shown to be age (OR 1.02, 95% CI 1.01–1.04, P = 0.010), laxatives use (OR 1.76, 95% CI 1.17–2.64, P = 0.007), gastric neoplasms (OR 2.16, 95% CI 1.23–3.81, P = 0.008), and CD (OR 1.64, 95% CI 1.16–2.31, P = 0.005). Early colon cancer in the distal colon was most frequently detected in patients with right‐sided CD (RR 2.50, P = 0.001). Conclusion In Japanese patients, early colon cancer was more frequently found in those with as compared to those without CD. The presence of CD may be an important indicator for an index colonoscopy examination to detect colon cancer. (Clinical‐trial‐registry: UMIN000038985).

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Relationship between colonic diverticulosis and colon neoplasms in Japanese patients

Nakahara

Amano

Murakami

et al. 2020

Digestive Endoscopy

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“…Understanding of available information regarding the potential of neoplastic progression in BE prior to endoscopic surveillance is inevitably important. While several clinical risk factors, such as male gender, aging, smoking, high-fat diet, obesity, reflux esophagitis, colon neoplasms, as well as others, are well-known important predictors of Barrett’s carcinogenesis [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ], they are not considered to be fully reliable indicators of neoplastic progression in all patients with BE. However, presence of erosive esophagitis or recurrent gastroesophageal reflux disease (GERD) symptom have been reported to be important predictors for neoplastic progression in BE as described below [ 19 , 20 ], and subsequently, proton pump inhibitor (PPI) use was protective against the progression [ 12 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Is Malignant Potential of Barrett’s Esophagus Predictable by Endoscopy Findings?

Amano

Ishimura

Ishihara

2020

Life

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Given that endoscopic findings can be used to predict the potential of neoplastic progression in Barrett’s esophagus (BE) cases, the detection rate of dysplastic Barrett’s lesions may become higher even in laborious endoscopic surveillance because a special attention is consequently paid. However, endoscopic findings for effective detection of the risk of neoplastic progression to esophageal adenocarcinoma (EAC) have not been confirmed, though some typical appearances are suggestive. In the present review, endoscopic findings that can be used predict malignant potential to EAC in BE cases are discussed. Conventional results obtained with white light endoscopy, such as length of BE, presence of esophagitis, ulceration, hiatal hernia, and nodularity, are used as indicators of a higher risk of neoplastic progression. However, there are controversies in some of those findings. Absence of palisade vessels may be also a new candidate predictor, as that reveals degree of intense inflammation and of cyclooxygenase-2 protein expression with accelerated cellular proliferation. Furthermore, an open type of mucosal pattern and enriched stromal blood vessels, which can be observed by image-enhanced endoscopy, including narrow band imaging, have been confirmed as factors useful for prediction of neoplastic progression of BE because they indicate more frequent cyclooxygenase-2 protein expression along with accelerated cellular proliferation. Should the malignant potential of BE be shown predictable by these endoscopic findings, that would simplify methods used for an effective surveillance, because patients requiring careful monitoring would be more easily identified. Development in the near future of a comprehensive scoring system for BE based on clinical factors, biomarkers and endoscopic predictors is required.

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Association between gastroesophageal reflux disease and colorectal cancer risk: a population-based cohort study

Hsu

et al. 2021

Int J Colorectal Dis

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Relationship between Barrett’s esophagus and colonic diseases: a role for colonoscopy in Barrett’s surveillance

Cited by 5 publications

References 55 publications

Relationship between colonic diverticulosis and colon neoplasms in Japanese patients

Relationship between colonic diverticulosis and colon neoplasms in Japanese patients

Is Malignant Potential of Barrett’s Esophagus Predictable by Endoscopy Findings?

Association between gastroesophageal reflux disease and colorectal cancer risk: a population-based cohort study

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