Relationship between blood lead levels and renal function in lead battery workers

Wang, Ven-Shing; Lee, Ming‐Tsung; Chiou, Jyh-Yann; Guu, Chiam-Fang; Wu, Chi‐Rei; Wu, Tai‐Hsi; Lai, Jin-Shin

doi:10.1007/s00420-002-0362-0

Cited by 48 publications

(32 citation statements)

References 30 publications

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“…A significant increase in the UA levels in lead-exposed workers (PbB = 29.1 μg/dl) was reported in a study by Khan also found significantly increased UA levels in workers exposed to high doses of lead (PbB = 80.9 μg/dl). Consistently, a positive correlation between blood lead levels and UA concentrations was found in several studies (16)(17)(18). Furthermore, the comparison of 2 groups of workers with PbB ≤ 60 μg/dl and PbB > 60 μg/dl showed a significant difference in the UA concentrations.…”

Section: Discussionsupporting

confidence: 82%

“…Therefore, hyperuricemia may be due to increased tubular reabsorption or decreased tubular secretion of UA (17,23). In addition, because lead nephropathy is associated with interstitial fibrosis and glomerular sclerosis (18), decreased glomerular filtration may result in elevated UA levels. Finally, the increase in UA concentrations may be a result of lead-induced alterations in purine metabolism.…”

Section: Discussionmentioning

confidence: 99%

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The Effect of Occupational Exposure to Lead on the Non-Enzymatic Antioxidant System

Dobrakowski¹,

Zalejska–Fiolka²,

Wielkoszyński³

et al. 2014

Med Pr

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Background: The role of non-enzymatic antioxidants, such as uric acid, albumin, bilirubin, and α-tocopherol, in lead poisoning remains unclear. Therefore, the aim of the study was to explore the association between occupational exposure to lead and nonenzymatic antioxidant concentrations in serum and plasma. Material and Methods: The study population consisted of 278 healthy male employees of lead-zinc plants, with 129 workers classified as having low lead exposure (blood lead level -PbB = 20-39.9 μg/dl) and 149 workers classified as having high lead exposure (PbB = 40-59.8 μg/dl). The control group was composed of 73 healthy male administrative workers. No one from this group had blood lead level or zinc protoporphyrin (ZPP) level greater than normal levels, being 10 μg/dl and 2.5 μg/g of hemoglobin, respectively. In addition to the levels of PbB and ZPP, serum levels of uric acid (UA), albumin, thiol groups of albumin, and bilirubin were determined. The ferric reducing ability of plasma (FRAP) and the plasma level of α-tocopherol were also evaluated. Results: Lead exposure indices were significantly elevated in the examined subgroups as compared with the controls. Serum uric acid levels were significantly elevated in both subgroups, particularly in the group with high exposure. Serum bilirubin concentration was significantly elevated in the group with high exposure compared with the control group, while in the group with low exposure, it showed only a non-significant trend towards an increase. In contrast, ferric-reducing ability of plasma was not significantly greater in the examined subgroups as compared with the control group. Nevertheless, levels of albumin, thiol groups of albumin, and α-tocopherol levels were significantly decreased in the exposed subgroups compared with the control group. Conclusions: Occupational exposure to lead interferes with the blood non-enzymatic antioxidant system. Med Pr 2014;65(4): [443][444][445][446][447][448][449][450][451]

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

The Effect of Occupational Exposure to Lead on the Non-Enzymatic Antioxidant System

Dobrakowski¹,

Zalejska–Fiolka²,

Wielkoszyński³

et al. 2014

Med Pr

View full text Add to dashboard Cite

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“…15 This result also might be due to the shorter duration of lead exposure time in our study than the other studies. 10,15,[19][20][21] Alasia et al 10 reported the mean duration of occupation in the study subjects as 11.9 years. Furthermore, Ehrlich et al 15 reported the mean exposure as 11.6 years.…”

Section: Discussionmentioning

confidence: 87%

“…10,[18][19][20][21][22] Additionally, it has been mentioned that serum creatinine levels were also higher in those subjects. In our study, although we have observed increased serum uric acid levels in the lead-exposed group; serum urea and creatinine levels were similar between the groups.…”

Section: Discussionmentioning

confidence: 94%

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The Effects of Lead Exposure on Serum Uric Acid and Hyperuricemia in Young Adult Workers: A Cross-sectional Controlled Study

et al. 2016

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Objectives: This study aims to evaluate the relationship between serum uric acid levels and renal functions in asymptomatic subjects who had occupational lead exposure, particularly for shorter durations whereby saturnine gout has also been discussed. Patients and methods:In this retrospective study, files of 100 males (mean age 34.5±5.9 years; range, 21 to 47 years) with occupational risk for lead exposure and 100 healthy male controls (mean age 34.47±5.8 years; range 21 to 47 years) were reviewed. Demographic characteristics of the subjects and laboratory test results were recorded from the files. Creatinine clearance and 24-hour urinary creatinine were measured in the lead-exposed group. Results: In the lead-exposed group, mean serum uric acid level was higher than those of the control group (p<0.001). Lead exposure time was negatively correlated with 24-hour urinary creatinine levels (r= -0.373, p<0.001). In addition, serum uric acid levels were positively correlated with serum creatinine levels (r=0.412, p<0.001) in the exposed group. Six patients had hyperuricemia (serum uric acid level >6.8 mg/dL) in the leadexposed group; however, all subjects' serum uric acid level was lower than 6.8 mg/dL in the control group (p=0.029). Although 22 subjects had higher uric acid levels than 6.0 mg/dL in the lead-exposed group, only one control had higher uric acid level than 6.0 mg/dL (p<0.001). Conclusion:In light of our results, we may conclude that workers with lead exposure have higher frequency of hyperuricemia and higher serum uric acid levels than those of the control group. Therefore, we may imply that higher serum uric acid levels may be associated with renal impairment in lead-exposed subjects even in the earlier stages of exposure.

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Occupational exposures and chronic kidney disease: Possible associations with endotoxin and ultrafine particles

Sponholtz

Sandler

Parks

et al. 2015

American J Industrial Med

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Background Chronic kidney disease (CKD) carries a high public health burden yet there is limited research on occupational factors, which are examined in this retrospective case-control study. Methods Newly diagnosed cases of CKD (n=547) and controls (n=508) from North Carolina provided detailed work histories in telephone interviews. Unconditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Results There was heterogeneity in the association of CKD and agricultural work, with crop production associated with increased risk and work with livestock associated with decreased risk. Work with cutting/cooling/lubricating oils was associated with a reduced risk. CKD risk was increased for working in dusty conditions. Conclusions CKD risk was reduced in subjects with occupational exposures previously reported to involve endotoxin exposure. Further, exposure to dusty conditions was consistently associated with increased risk of glomerulonephritis across industry, suggesting that research on CKD and ultrafine particulates is needed.

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Relationship between blood lead levels and renal function in lead battery workers

Abstract: Blood-urea nitrogen and uric acid could be considered as suitable prognostic indicators of renal dysfunction in lead-exposed workers. Our results showed that PbB levels higher than 60 micro g/dl had increasing chances of inducing adverse renal effects.

Cited by 48 publications

References 30 publications

The Effect of Occupational Exposure to Lead on the Non-Enzymatic Antioxidant System

The Effect of Occupational Exposure to Lead on the Non-Enzymatic Antioxidant System

The Effects of Lead Exposure on Serum Uric Acid and Hyperuricemia in Young Adult Workers: A Cross-sectional Controlled Study

Occupational exposures and chronic kidney disease: Possible associations with endotoxin and ultrafine particles

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