Relationship between blood manganese levels and children's attention, cognition, behavior, and academic performance—A nationwide cross-sectional study

Bhang, Soo-Young; Cho, Soo Churl; Kim, Jae Won; Hong, Yun Chul; Shin, Min Sup; Yoo, Hee Jeong; Cho, In Hee; Kim, Yeni; Kim, Bung Nyun

doi:10.1016/j.envres.2013.05.006

Cited by 86 publications

(75 citation statements)

References 30 publications

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“…For example, the nervous system of welding workers exposed to Mn for a long time was hurt [5][6][7]. Excess Mn was associated with lower scores of thinking, reading, calculation, and LQ in the Learning Disability Evaluation Scale and higher scores of commission error in the attention-deficit/hyperactivity disorder diagnostic system in 8-11-old children in South Korea [8]. Chronic Mn exposure impaired glutamatergic function in the majority of regions of the brain, perturbed GABAergic activity in the basal ganglia, and altered behavior in mice [9].…”

Section: Introductionmentioning

confidence: 95%

Toxicological Effect of Manganese on NF-κB/iNOS-COX-2 Signaling Pathway in Chicken Testes

Zhu

Teng³

et al. 2015

Biol Trace Elem Res

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Manganese (Mn) pollution can cause tissue and organ dysfunction and structural damage. The toxicity of Mn in poultry was reported, but inflammatory damage that Mn induced in the testicular tissue has not been reported. The aim of this study was to investigate the effect of Mn poisoning on NF-κB/iNOS-COX-2 signaling pathway in chicken testes. One hundred eighty Hyline male chickens at 7 days of age were fed either commercial diet or MnCl2-added commercial diet containing 600, 900, and 1800 mg/kg Mn for 30, 60, and 90 days, respectively. The messenger RNA (mRNA) expression of nuclear factor-κB (NF-κB), tumor necrosis factor-α (TNF-α), cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS), nitric oxide (NO) content, iNOS activity, and histopathology were examined in chicken testes. The results showed that excess Mn upregulated mRNA expression of NF-κB, COX-2, TNF-α, and iNOS, NO content, and iNOS activity at 60th and 90th day. Mn had a time-dependent effect on NF-κB and TNF-α mRNA expression. Mn had a dose- and time-dependent effect on NO content and iNOS activity. Mn exposure induced chicken testis histological changes in dose- and time-dependent manner. It indicated that Mn exposure resulted in inflammatory injury of chicken testis tissue through NF-κB/iNOS-COX-2 signaling pathway.

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Section: Introductionmentioning

confidence: 95%

Toxicological Effect of Manganese on NF-κB/iNOS-COX-2 Signaling Pathway in Chicken Testes

Zhu

Teng³

et al. 2015

Biol Trace Elem Res

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“…60 Other problems associated with a possible Mn deficiency include inflammatory diseases, 61 altered exocrine and endocrine activities, 3 and problems with fetal growth 62 and cognitive function. 63 A common basis may be related to diminished activity of MnSOD2, an essential antioxidant enzyme. MnSOD2 has a critical role in reducing oxidative stress by combating the formation of reactive oxygen species (ROS).…”

Section: Deficienciesmentioning

confidence: 99%

“…A cross-sectional study found that Korean children (8-11 years old) with low blood Mn values (o8.5 mg l À1 ) had reduced color scores on the Stroop test (r52.0) (stating the color of a presented word). 63 Thus, maintenance of optimal Mn status in schoolchildren is critical to cognitive health and, presumably, school performance.…”

Section: Deficienciesmentioning

confidence: 99%

Nutritional Requirements for Manganese

Freeland‐Graves¹,

Mousa²,

Sanjeevi³

2014

Manganese in Health and Disease

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Manganese (Mn) is a ubiquitous trace mineral that is essential for living organisms. This mineral is a cofactor of enzymes such as superoxide dismutase and arginase. It assumes a significant role in the metabolism of carbohydrates, amino acids and cholesterol, the formation of bone, digestion, and development. Food sources include whole grains, cereals, green leafy vegetables, nuts, and tea. Approaches to assess Mn requirements include metabolic balance, blood levels, and response of biomarkers. In the United States, the adequate intake (AI) of Mn is 1.8 and 2.3 mg day−1 for women and men, respectively. Negative balance has been reported in numerous studies, where Mn intake was greater than the AI; thus, the adequacy of current dietary recommendations is unclear. Factors that influence Mn requirements include life stage and gender, bioavailability (fiber, phytates, mineral interactions, polyphenolic compounds), and international considerations. Deficiency of Mn has been associated with adverse health conditions including dermatitis, osteoporosis, dyslipidemia, diabetes, metabolic syndrome, hypertension, epilepsy, cancer, asthma, problems with cognitive function, and poor birth outcomes. Toxicity of Mn may be a potential problem with contaminated drinking water, parenteral nutrition, individuals with hepatic dysfunction, and soy formula-fed infants. An understanding of Mn nutrient requirements is important for achievement of optimal health.

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“…Similarities and differences between the two conditions have been reviewed by Guilarte 37,55 . Mn has also been implicated in learning and developmental cognitive defects in rodents 56 , non-human primates 57 , and humans 58,59 .…”

Section: Introductionmentioning

confidence: 99%