Relationship between bone metabolic markers and bone mineral density in natural postmenopausal women

Abstract

Objective: To investigate the relationship between bone metabolic markers and bone mineral density (BMD) in natural postmenopausal women more than 2 years after menopause. Methods: A total of 147 women aged 45-72 years who had undergone natural menopause for more than 2 years were selected. Dual-energy X-ray Absorptiometry (DEXA) was used to scan the standard BMD of the lumbar spine and hip. Fasting venous blood was collected in the morning to detect serum bone metabolism markers like amino-terminal pro-peptide of type Ⅰ pro-collagen (PINP) and β-collagen degradation products (β-CTX). According to BMD the patients were divided into normal bone mass group, osteopenia group and osteoporosis group. The differences of PINP and β-CTX among the three groups were compared. The correlation between PINP, β-CTX and general data was analyzed. The correlation between lumbar BMD, hip BMD and each variable; Correlation between β-CTX and P1NP, lumbar spine BMD and hip BMD. Results: P1NP had no significant difference among the three groups. PINP and β-CTX were not correlated with age, menopausal age, height, weight, BMI and glycosylated hemoglobin (P > 0.05). Lumbar spine BMD was correlated with age, menopausal age, height, weight and BMI (P < 0. 05), but not with Hba1c, PINP and β-CTX. Hip BMD was correlated with menopausal age, height, weight, BMI and β-CTX (P < 0. 05), but not with age, Hba1c and P1NP. 05), and lumbar BMD was correlated with hip BMD (P < 0. 05). Conclusion: Bone resorption and bone formation are in a state of high metabolism, and osteoporosis patients may lose bone mass faster. Bone mineral density is better than PINP and β-CTX in reflecting bone mass.