Relationship Between Brain Amyloid Deposition and Instrumental Activities of Daily Living in Older Adults: A Longitudinal Study from the Multidomain Alzheimer Prevention Trial

Lilamand, Matthieu; Cesari, Matteo; Cantet, Christelle; Payoux, Pierre; Andrieu, Sandrine; Vellas, Bruno

doi:10.1111/jgs.15497

Cited by 11 publications

(16 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Prior studies in CN participants have shown associations between amyloid burden and objective and subjective cognitive function 23–26 but only limited evidence for a relationship with IADL difficulties 16,17 . The current analyses demonstrated an association among IADL, amyloid burden, objective cognition, and subjective cognitive concerns.…”

Section: Discussioncontrasting

confidence: 48%

Instrumental activities of daily living, amyloid, and cognition in cognitively normal older adults screening for the A4 Study

Marshall

Sikkes

Amariglio

et al. 2020

Alzheimer's & Dementia: Diagnosis, Assessment &

View full text Add to dashboard Cite

Introduction We examined the associations among instrumental activities of daily living (IADL), cortical amyloid, and cognition in cognitively normal (CN) older adults. Methods CN participants screening for the A4 Study (n = 4486) underwent florbetapir (amyloid) positron emission tomography. IADL were assessed using the Alzheimer's Disease Cooperative Study Activities of Daily Living Prevention Instrument. Separate logistic regression models were run with cortical amyloid or cognition as independent variable and IADL as dependent variable, adjusting for age and sex. Results IADL difficulties were endorsed infrequently (≤16%). Overall IADL and four select IADL item difficulties (“remembering appointments,” “finding belongings,” “following TV programs,” and “remembering current events”) reported by both participant and study partner were significantly associated with greater amyloid burden and worse cognition. Discussion Although IADL deficits were infrequent in this CN cohort, greater participant and study partner report of overall IADL deficits and subtle difficulties in specific IADL items were associated with mildly higher amyloid burden and worse cognition.

show abstract

Section: Discussioncontrasting

confidence: 48%

Instrumental activities of daily living, amyloid, and cognition in cognitively normal older adults screening for the A4 Study

Marshall

Sikkes

Amariglio

et al. 2020

Alzheimer's & Dementia: Diagnosis, Assessment &

View full text Add to dashboard Cite

show abstract

“…Current findings are in line with a recent study suggesting that amyloid‐positive and ‐negative individuals might have different IADL trajectories, 1 with previous studies suggesting that baseline MRI biomarkers could predict IADL worsening over time regardless of cognitive status 10 and that higher disability in ADL ability is associated with greater pathological burden (e.g., neuritic plaque and neurofibrillary tangle counts) in patients with dementia due to AD 30 . A review 31 showed that neuroanatomical changes (e.g., hippocampal atrophy, white matter changes) were associated with IADL, independent of cognition, but to a lesser extent; cognitive function seemed to be a stronger IADL predictor than brain morphological changes.…”

Section: Discussionsupporting

confidence: 92%

“…IADL are complex, involving multiple higher cognitive functions, are important for autonomous living and decline earlier than more basic ADL. Although cognitive outcomes in association with brain amyloid accumulation have been described more thoroughly, functional trajectories of activities of daily living have been studied in less detail 1 …”

Section: Introductionmentioning

confidence: 99%

“…In addition, previous research suggests that elevated brain amyloid is associated with lower ADL and IADL abilities, 3‐6 and that there is an association between IADL disability and brain hypometabolism, 7‐9 and MRI neurodegeneration biomarkers 10‐12 . Studies also suggested that baseline MRI biomarkers predict future IADL worsening across the AD spectrum, 10 and that ND individuals might have different trajectories in IADL performance depending on brain amyloid status 1 …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Brain amyloid, cortical thickness, and changes in activities of daily living

Vassilaki

Aakre

Kremers

et al. 2020

Ann Clin Transl Neurol

View full text Add to dashboard Cite

Objective: To examine the association of baseline elevated brain amyloid and neurodegeneration with changes in activities of daily living in participants without dementia (ND; i.e., cognitively unimpaired and participants with mild cognitive impairment) at baseline in the population-based Mayo Clinic Study of Aging. Methods: We included 1747 ND participants with 11 C-PiB PET and MR imaging in the study, with data on activities of daily living (as assessed by the Functional Activities Questionnaire (FAQ) and the Clinical Dementia Rating scale Sum of Boxes for functional domains (CDR-SOB (functional)), with a median (range) of 4.3 (0.0-12.7) years of follow-up. Abnormal (elevated; A+) 11 C-PiB-PET retention ratio was defined as standardized uptake value ratio ≥ 1.48, and abnormal (reduced) AD signature cortical thickness as ≤ 2.68 mm (neurodegeneration; N+). Associations were examined with mixed effects models, adjusting for age, sex, education, apolipoprotein E e4 allele carrier status, and global cognitive z-score. Results: Mean age (SD) was 71.4 years (10.1), 46.7% were females, 195 (11.2%) had A+N-, 442 (25.3%) had A-N+, and 339 (19.4%) had A+N+ biomarkers. The A+N+ group had the largest annualized change in the FAQ score from baseline (difference in annual change A+N+ vs. A-N-; ß (SE): 0.80 (0.07)); associations were substantially attenuated when a time-varying global cognitive composite was included in the model (A+N+ vs. A-N-; ß (SE): 0.31 (0.05)). CDR-SOB (functional) findings partly agreed with FAQ score findings. Interpretation: The longitudinal increase in functional limitations is greater for individuals with abnormal neuroimaging biomarkers, especially for those with both elevated brain amyloid and neurodegeneration. 474

show abstract

“…We report here a secondary analysis of the Multidomain Alzheimer's Preventive Trial (MAPT), whose methods have been published elsewhere 21‐26 (see Supplementary Appendix S1). This randomized controlled trial assessed the cognitive impact of a 3‐year multidomain intervention, supplementation with omega‐3 fatty acids, or their combination, in 1,679 participants.…”

Section: Methodsmentioning

confidence: 99%

Kidney Function and Cognitive Decline in Older Adults: Examining the Role of Neurodegeneration

Guerville

Barreto

Coley

et al. 2020

J American Geriatrics Society

Self Cite

View full text Add to dashboard Cite

BACKGROUND/OBJECTIVES Cognitive decline associated with impaired kidney function might involve neurodegeneration. Our objectives were to evaluate the longitudinal association between kidney function and cognitive decline in older adults and to assess the involvement of cortical beta‐amyloid and hippocampal atrophy (features of Alzheimer's disease (AD)) in this association. DESIGN Secondary analysis of the randomized controlled Multidomain Alzheimer Preventive Trial (MAPT). SETTINGS Thirteen memory centers (France and Monaco, 2008–2016). PARTICIPANTS A total of 1,334 community‐dwellers >70 years old without dementia at baseline. MEASUREMENTS We estimated glomerular filtration rate (eGFR) from serum creatinine using CKD‐Epi equation. Cognition was assessed at baseline, 6, 12, 24, 36, 48, and 60 months using a composite Z‐score designed for MAPT. The Clinical Dementia Rating (CDR) score was used to assess cognition and functional independence. We examined the association between eGFR and (1) evolution of the composite cognitive Z‐score using mixed‐effect models and (2) progression on CDR using Cox models and mixed‐effect models. Adjustments were made for age, sex, education, ApoE genotype, cardiovascular risk factors and disease, hippocampal volume (measured with magnetic resonance), and cortical beta‐amyloid (measured with positron emission tomography). RESULTS Median (IQR) eGFR was 73(60–84) mL/min/1.73 m2. Two hundred sixty‐nine participants experienced progression on CDR score during follow‐up. eGFR<60 was significantly associated with progression on CDR score (adjusted hazard ratio (aHR) = 1.35, 95% CI 1.01–1.80) and with both the cognitive and functional independence components of CDR, but not with the evolution of the composite cognitive Z‐score (adjusted β‐coefficient −0.004, 95% CI −0.014; 0.006). Associations were not modified after further adjustment for beta‐amyloid (subsample: n = 252) and hippocampal volume (subsample: n = 270). CONCLUSIONS We did not find a mild to moderate renal insufficiency to be associated with brain imaging features of AD, and our results do not support the involvement of AD mechanisms in the incidence of cognitive impairment and functional decline associated with chronic kidney disease.

show abstract

Relationship Between Brain Amyloid Deposition and Instrumental Activities of Daily Living in Older Adults: A Longitudinal Study from the Multidomain Alzheimer Prevention Trial

Abstract: Amyloid-positive and -negative older adults are likely to have different trajectories in IADL performance. Future research is needed to better understand the relationship between amyloid plaques and functional limitations.

Cited by 11 publications

References 35 publications

Instrumental activities of daily living, amyloid, and cognition in cognitively normal older adults screening for the A4 Study

Instrumental activities of daily living, amyloid, and cognition in cognitively normal older adults screening for the A4 Study

Brain amyloid, cortical thickness, and changes in activities of daily living

Kidney Function and Cognitive Decline in Older Adults: Examining the Role of Neurodegeneration

Contact Info

Product

Resources

About