Relationship Between c-Jun N-terminal Kinase and Depression

Ma, Hongpeng

doi:10.1051/e3sconf/202018503029

Cited by 2 publications

(2 citation statements)

References 56 publications

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“…JNK1/c-Jun signalling is important in the pathogenesis of CP [ 57 , 58 ]. JNK also plays an important role in the development of depression via several physiological processes, such as inflammation, oxidative stress, cell death and neurogenesis [ 59 ]. For example, intracerebral ventricular infusion with a JNK inhibitor DJNKI-1 in mice can promote adult hippocampal neurogenesis in the hippocampus to alleviate anxiety [ 60 ].…”

Section: Discussionmentioning

confidence: 99%

A network pharmacology approach to predict potential targets and mechanisms of “ Ramulus Cinnamomi (cassiae) – Paeonia lactiflora ” herb pair in the treatment of chronic pain with comorbid anxiety and depression

Pan

Wei

et al. 2022

Annals of Medicine

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Background Traditional Chinese medicine (TCM) prescriptions have multiple bioactive properties. “Gui Zhi–Shao Yao” herb pair is widely used to treat chronic pain (CP), as well as anxiety and depression. However, its related targets and underlying mechanisms have not been deciphered. Methods In this study, the network pharmacology method was used to explore the bioactive components and targets of “Gui Zhi–Shao Yao” herb pair and further elucidate its potential biological mechanisms of action in the treatment of CP with comorbid anxiety disorder (AD) and mental depression (MD). Results Following a series of analyses, we identified 15 active compounds, hitting 130 potential targets. After the intersections the targets of this herb pair and CP, AD and MD – sorted by the value of degree – nine targets were identified as the vital ones: Akt1, IL6, TNF, PTGS2, JUN, CASP3, MAPK8, PPARγ and NOS3. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis results demonstrated 11 pathways, such as AGE-RAGE signalling pathway, IL-17 signalling pathway, TNF signalling pathway, which primarily participate in the pathological processes. Conclusions This study preliminarily predicted and verified the pharmacological and molecular mechanisms of “Gui Zhi–Shao Yao” herb pair for treating CP with comorbid AD and MD from a holistic perspective. In vivo and in vitro experiments will be required to further investigate the mechanisms. KEY MESSAGE A network pharmacology approach was applied to identify key targets and molecular mechanisms. Nine targets were regarded as the vital targets for chronic pain with comorbid anxiety and depression. Predicted 11 pathways were the potential therapy targets and pharmacological mechanism of “Gui Zhi–Shao Yao” herb pair.

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Section: Discussionmentioning

confidence: 99%

A network pharmacology approach to predict potential targets and mechanisms of “ Ramulus Cinnamomi (cassiae) – Paeonia lactiflora ” herb pair in the treatment of chronic pain with comorbid anxiety and depression

Pan

Wei

et al. 2022

Annals of Medicine

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“…Hepatotoxicity-reducing activity has also been reported to be carried out by xanthorizol. A possible pathway is decreased phosphorylation of c-Jun Nterminal kinases (JNK) [37]. Xanthorrhizol or curcumin also can regulate DNA binding to the transcription factors nuclear factors kappa B (NF-αB) and AP-1 [38].…”

Section: Groupmentioning

confidence: 99%

Transaminase Enzyme Activity and Histopathology Evaluation of Ratâ€™s Liver Induced by DMBA with Temulawak Extract (Curcuma xanthorrhiza)

Hasan¹,

Falah²,

Handharyani³

et al. 2023

Int. J. Adv. Sci. Eng. Inf. Technol.

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Temulawak rhizome (Curcuma xanthorrhiza) contains curcumin and xanthorrhizol, which may be used as breast cancer drugs and hepatoprotection. This study aims to analyze the activity of alanine and aspartate transaminase enzymes and the histopathological picture of 7,12-Dimethylbenz(α)anthracene (DMBA)-induced rat liver due to the administration of temulawak extract. This study used 28 female white rats, divided into seven treatment groups, a control group (normal and DMBA) and a treatment group induced by temulawak extract orally with doses of 35, 70, 140, 210, and 280 mg/kg Body Weight (BW) during the 11-week study period. The results obtained were that the application of temulawak extract had a significant effect on alanine transaminase (ALT) levels but did not differ between groups. Aspartate transaminase (AST) levels differed at a 35 mg/kg BW dose. Temulawak extract at a dose of 140 mg/kg BW, the De Ritis ratio at normal values. The results of the histopathological analysis showed hepatocyte repair and sinusoidal dilatation were less than optimal at a dose of 140 mg/kg BW. This study concluded that the temulawak extract showed a significant but insignificant difference in the ALT value. The AST value significantly differed in administering temulawak extract at a dose of 35 mg/kg BW. The dose of 140 mg/kg BW controls the value of the De Ritis ratio to the normal value. Temulawak extract is expected to improve the healing of the liver damaged by carcinogenic substances.

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Relationship Between c-Jun N-terminal Kinase and Depression

Cited by 2 publications

References 56 publications

A network pharmacology approach to predict potential targets and mechanisms of “ Ramulus Cinnamomi (cassiae) – Paeonia lactiflora ” herb pair in the treatment of chronic pain with comorbid anxiety and depression

A network pharmacology approach to predict potential targets and mechanisms of “ Ramulus Cinnamomi (cassiae) – Paeonia lactiflora ” herb pair in the treatment of chronic pain with comorbid anxiety and depression

Transaminase Enzyme Activity and Histopathology Evaluation of Ratâ€™s Liver Induced by DMBA with Temulawak Extract (Curcuma xanthorrhiza)

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