Relationship between cancer cell proliferation, tumour angiogenesis and 201Tl uptake in non-small cell lung cancer

Abstract

201Tl SPECT imaging is effective non-invasive method for assessing both the proliferation and the angiogenesis in NSCLC. Both DR and RI are useful indicators for assessing cancer cell proliferation in lung adenocarcinoma. ER is a useful marker for assessing the tumour angiogenesis in NSCLC.

Usefulness of triple-phase thallium-201 SPECT in non-small-cell lung cancer (NSCLC): association with proliferative activity

“…Earlier, we reported the close association between the early uptake of 201 Tl and tumor angiogenesis [8,9]. We also found that the positive correlation between delayed uptake of 201 Tl and cancer cell proliferation or lymph node metastasis potential [8,9]. However, the infl uence of blood fl ow may remain on the conventional delayed image in NSCLC patients such as the cases with complicated infl ammation.…”

“…It is known that retention index of 201 Tl is closely related with cellular malignancy such as differentiation degree or proliferation potential [8,9,12,14]. Earlier, we also reported the close connection between tumor 201 Tl uptake and angiogenesis or cell proliferation [9]. We reevaluated the issue using a super-delayed image in the current study.…”

“…Radionuclide delayed imaging with thallium-201 ( 201 Tl) has also been advocated to distinguish benign lesions from malignant lesions and to identify lymph node metastasis [2][3][4][5][6][7]. Earlier, we reported the close association between the early uptake of 201 Tl and tumor angiogenesis [8,9]. We also found that the positive correlation between delayed uptake of 201 Tl and cancer cell proliferation or lymph node metastasis potential [8,9].…”

“…The other issue is the association between tumor 201 Tl uptake and biological behavior [19][20][21][22][23][24]. It is known that retention index of 201 Tl is closely related with cellular malignancy such as differentiation degree or proliferation potential [8,9,12,14]. Earlier, we also reported the close connection between tumor 201 Tl uptake and angiogenesis or cell proliferation [9].…”

Microvascular density and endothelial area correlate with Ki-67 proliferative index in surgically-treated pancreatic ductal adenocarcinoma patients

“…MVD and EA have been experimentally proposed to be biomarkers associated with biological aggressiveness and clinical outcome in animal and human malignancies. In regards to pancreatic cancer, it has been established that angiogenesis has a role in its development and progression (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). In addition, Ki-67 expression is an important parameter for biological aggressiveness and prognosis in tumour tissue; Ki-67 antigens are initially expressed in S-phase and increase throughout S-and G 2 -phase until they reach their peak expression during mitosis.…”