Relationship Between Carotid Intima-Media Thickness and Symptomatic and Asymptomatic Peripheral Arterial Disease

Allan, Paul L.; Mowbray, Philip I.; Lee, A. J.; Fowkes, F. G. R.

doi:10.1161/01.str.28.2.348

Cited by 335 publications

(222 citation statements)

References 36 publications

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“…Kollias and colleagues reported that the left‐side IMT was higher and more closely related to CV risk factors (mainly systolic BP) than that on the right side in children 35. Several other studies also demonstrated that IMT is higher on the left side than the right side in middle‐aged or older populations 36, 37. These results were consistent with our study to some extent.…”

Section: Discussionsupporting

confidence: 93%

Growth of Carotid Intima‐Media Thickness in Black and White Young Adults

Hao

Wang

Treiber

et al. 2016

JAHA

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BackgroundThere are few longitudinal studies that have comprehensively examined the intima‐media thickness (IMT) growth pattern and its determinants among racial population groups.Methods and ResultsMean and maximum IMT were measured by B‐mode ultrasonography up to 3 times in 253 white and 268 black participants, aged 13 to 36 years (mean age±standard deviation 24±3.2 years old). The development of IMT was assessed using individual growth curve modeling. A total of 521 participants with 1015 IMT measurements were eligible for this study. We found higher IMT in both left and right sides in blacks compared to whites (P<0.001) in young adulthood. Both whites and blacks showed a strong linear increase in mean IMT with age. Body mass index and father's education level were associated with mean IMT, and only body mass index was associated with maximum IMT (P<0.05). We did not observe an interaction between age and race/ethnicity on the growth of IMT, suggesting that blacks and whites developed IMT in similar patterns. Interestingly, we found a faster increase in mean left‐side IMT than mean right‐side IMT (χ2=11.5, P<0.001) in both black and white subjects as well as in males and females.ConclusionsOur findings provide compelling prospective evidence that blacks may have thicker IMT compared to whites as young adults. These racial differences could not be explained by traditional risk factors. This implies that differences in this precursor of atherosclerosis may explain racial disparity in cerebrovascular disease.

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Section: Discussionsupporting

confidence: 93%

Growth of Carotid Intima‐Media Thickness in Black and White Young Adults

Hao

Wang

Treiber

et al. 2016

JAHA

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“…In several studies of IMT in several age groups all measurements were performed without taking atherosclerotic lesion into account [6,7]. In means that data were received by measurements in full range from plaque free to significant atherosclerotic lesion zones of carotid arteries.…”

Section: Discussionmentioning

confidence: 99%

ge dependent vascular remodeling in elderly patients with arterial hypertension

Malinova¹,

Sadjaya²,

Tikhonova³

2012

RusOMJ

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Purpose: to estimate morphological markers of vascular remodeling in elderly patients with arterial hypertension. Material: 179 elderly patients with arterial hypertension were involved in the study. Mean intima media thickness (IMT) of common carotid arteries at plaque-free sites and prevalence of plaques were evaluated by B-mode ultrasound (Philips Envisor HD, USA). Results: IMT changing was of nonlinear character. IMT remained stable up to 74 years. Mean rate of the subsequent IMT augmentation was 0.157 mm per year. Frequency of atherosclerotic plaque revealing was significantly increased since 7th decade. No significant correlation between IMT and systolic, diastolic, mean blood pressure levels, or medication spectra was revealed. Conclusion: Received data can be considered as the evidence of significant ageing influence upon IMT enlargement.

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“…An important predictive phenotype for human cardiovascular disease is carotid IMT (23,24). Measuring the IMT may be the best method for detecting early atherosclerosis and assessing the subsequent risk of cardiovascular events (stroke, myocardial infarction and peripheral vascular disease) (24)(25)(26)(27).…”

Section: Three Biological Laws Define Vascular Remodellingmentioning

confidence: 99%