Relationship between Central Corneal Thickness and Parameters of Optic Nerve Head Topography in Healthy Subjects

Ab, Cankaya; Elgin, Ufuk; Batman, Aygen; Acaroğlu, Gölge

doi:10.1177/112067210801800106

Cited by 21 publications

(14 citation statements)

References 30 publications

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“…They found smaller disc areas (1.83±0.35 mm 2 ) and smaller rim areas (1.27 mm 2 ) and slightly larger CDR (0.51±0.16) compared with our study. Large studies (n4100) that measured normal disc size using Stratus OCT 10,[21][22][23][24][25] have reported disc areas between 2.34 ± 0.41 and 2.63 ± 0.55 mm 2 , which are larger than our value of 1.98 ± 0.38 mm 2 . These studies also report cup-disc area ratios between 0.17 ± 0.11 and 0.37 ± 0.20, which are substantially smaller than our value of 0.44±0.18.…”

Section: Eyecontrasting

confidence: 53%

Retinal nerve fiber layer and optic disc measurements by spectral domain OCT: normative values and associations in young adults

Tariq

Burlutsky

et al. 2012

Eye

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Purpose To determine normative values and associations of retinal nerve fiber layer (RNFL) and optic disc parameters in normal eyes measured by spectral domain optical coherence tomography (OCT).Methods In a population-based setting, 1521 young adults were examined as part of the Sydney Adolescent Vascular and Eye Study (SAVES). Their mean age was 17.3 ± 0.6 years. RNFL and optic disc parameter measurements were made using Cirrus HD-OCT 4000. Results The average RNFL was found to be 99.4±9.6 lm. RNFL thickness was least for the temporal quadrant (69.9±11.2 lm), followed by the nasal (74.3 ± 12.8 lm), superior (124.7 ± 15.7 lm) and inferior (128.8 ± 17.1 lm) quadrants. The mean disc area in this population was 1.98 ± 0.38 mm 2 with a mean rim area of 1.50 ± 0.30 mm 2 and a mean cup/disc ratio of 0.44±0.18. Multivariate-adjusted RNFL thickness was marginally greater in East Asian than in white participants (100.1 lm vs 99.5 lm; P ¼ 0.0005). The RNFL was thinner with greater axial length (Po0.0001), less positive spherical equivalent refractions (Po0.0001), smaller disc area and rim area (Po0.0001). Conclusion This study documents normative values for the RNFL and optic disc measured using Cirrus HD-OCT in young adults. The values and associations reported in this study can inform clinicians on the normal variation in RNFL and optic disc parameters.

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Section: Eyecontrasting

confidence: 53%

Retinal nerve fiber layer and optic disc measurements by spectral domain OCT: normative values and associations in young adults

Tariq

Burlutsky

et al. 2012

Eye

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“…A biological link may exist between aspects of the cornea that regulate its thickness and the physical and structural properties of tissues involved in glaucoma pathogenesis, most notably the optic disc and lamina cribrosa. Several studies have found an association with CCT and various physical parameters of the optic disc, including disc area88 89 and depth of the cup 90. These findings are in contrast to those of Nicolela et al 91 and Wells et al 92 and who found no correlation between CCT and the optic disc rim area or cup depth.…”

Section: Why Study the Genetics Of Cct?mentioning

confidence: 85%

The genetics of central corneal thickness

Dimasi

Burdon

Craig

2009

British Journal of Ophthalmology

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Evidence in the recent literature has highlighted the importance of central corneal thickness (CCT) in relation to several ocular and non-ocular conditions. Most notably, thinner CCT has been identified as a risk factor for open-angle glaucoma. Despite having an extensive knowledge of the structure and function of the cornea, little is known about the pathways that determine CCT. There are data to suggest however that CCT has a strong genetic component. Heritability studies conducted in twins and family pedigrees indicate that CCT is one of the most highly heritable human traits, whereas data from a diverse range of ethnic groups show clear ethnic-related differences in CCT. Extreme CCT measurements have also been associated with rare genetic diseases. Although there is strong evidence supporting a genetic component to normal CCT variation, to date, no genes have been identified. This review investigates the current literature surrounding this topic and explores the significance of understanding the genetics of CCT and how this might benefit the field of open-angle glaucoma treatment and research.

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“…Many reports have suggested that the cornea is related to the optic nerve in some way; some clinicians have looked for a relationship between glaucoma and CCT. [7][8][9][10]18 A recent study found that CCT is not related to the risk of developing a glaucomatous visual field loss or progression, 19 and a histomorphometric study failed to find an association between CCT and the thickness of the lamina cribrosa. 12,20 However, these results did not provide a definitive answer regarding the relationship between the cornea and the optic disc.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have reported that thin corneas may have an association with weak optic nerve heads and that this may be related to a thin lamina cribrosa. 7,8 Furthermore, some studies have shown that the development and progression of glaucoma correlates with central corneal thickness; 9 other studies refute this claim. 10,11 Wells et al 11 insisted that corneal hysteresis, but not corneal thickness, correlates with the vulnerability of the optic nerve surface.…”

Section: Introductionmentioning

confidence: 94%

The relationship between the cornea and the optic disc

Kim

Park

Kim

et al. 2010

Eye

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Objective To evaluate the structural relationship between the cornea and the optic disc in normal subjects. Methods This hospital-based observational study included 205 eyes from 205 individuals who were diagnosed as normal at our glaucoma clinic. The subjects underwent an eye examination, optic disc imaging with optic disc photography, optical coherence tomography, IOL master, specular microscopy, and ultrasound corneal pachymetry. Results In univariate regression models (Pearson's correlation coefficient), the cup-to-disc (CD) ratio showed a negative correlation with corneal curvature (r ¼ À0.315, Po0.001) and central corneal thickness (r ¼ À0.206, P ¼ 0.005), and a positive correlation with white-to-white diameter (horizontal limbus to limbus distance, r ¼ 0.215, P ¼ 0.003). In multiple linear regression models with CD ratio as the dependant parameter, the CD ratio was still significantly associated with corneal curvature (b ¼ À0.205, P ¼ 0.011) and white-to-white diameter (b ¼ 0.207, P ¼ 0.010). The central corneal thickness failed to show statistical significance, but did show a negative correlation with borderline significance (b ¼ À0.133, P ¼ 0.075). Conclusions Eyes with a large CD ratio have large and flat corneas; this may suggest that there is a structural relationship between the cornea and the optic disc. These results can be helpful in analysing the anatomical relationship between the cornea and the optic disc.

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Relationship between Central Corneal Thickness and Parameters of Optic Nerve Head Topography in Healthy Subjects

Cited by 21 publications

References 30 publications

Retinal nerve fiber layer and optic disc measurements by spectral domain OCT: normative values and associations in young adults

Retinal nerve fiber layer and optic disc measurements by spectral domain OCT: normative values and associations in young adults

The genetics of central corneal thickness

The relationship between the cornea and the optic disc

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