Relationship Between Cerebrospinal Fluid Protein Levels and Electrophysiologic Abnormalities in Guillain–Barré Syndrome

DiCapua, Daniel; Lakraj, Amanda Amrita; Nowak, Richard J.; Robeson, Kimberly; Goldstein, Jonathan; Patwa, Huned

doi:10.1097/cnd.0000000000000091

Cited by 10 publications

(12 citation statements)

References 16 publications

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“…Higher CSF protein levels have been reported to show a significant loss of the blood brain barrier integrity 21 . Prognostic implications of CSF protein levels for disease activity have been shown in previous studies 6,15,22 . Our study was compatible with previous studies, and we found that higher CSF protein levels were correlated with worse prognosis on both the first day and first month.…”

Section: Discussionmentioning

confidence: 63%

“…Early predictions enable clinicians to provide proper and cost-effective treatments. Many studies have investigated the prognostic determinants of GBS 6,8,12,13,14 . We evaluated the clinical course at the end of the first day and first month, and we found that patients who satisfied a higher number of demyelinating criteria and exhibited higher CSF protein levels had increased disability scores in the first day and first month.…”

Section: Discussionmentioning

confidence: 99%

“…antibodies, which are markers for nervous system inflammation 7 . Approximately 50% of GBS patients may show elevated levels in the first week, and this ratio may rise to 80% in the second week 6 . In our study, lumbar puncture was performed at the end of the first day.…”

Section: Discussionmentioning

confidence: 99%

“…Cerebrospinal fluid (CSF) analysis and electrophysiological studies are crucial in the diagnosis of GBS 6 . Total CSF protein levels indicate active myelin breakdown and increased antibody depositions secondary to the inflammation 7 .…”

Section: The Prognostic Value Of Demyelinating Electrophysiologic Finmentioning

confidence: 99%

“…Most of these studies evaluated muscle strength at admission, presence of facial or bulbar muscle involvement, rapidly progression, preceding diarrhea, compound muscle action potential amplitude, and mechanical ventilation requirement as negative predictors of the outcome of GBS 12,14 . Only a few studies have reported the association of electrophysiological abnormalities, CSF proteins levels, and prognosis 6,13,15 .…”

Section: The Prognostic Value Of Demyelinating Electrophysiologic Finmentioning

confidence: 99%

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The prognostic value of demyelinating electrophysiologic findings and cerebrospinal fluid protein levels in acute inflammatory demyelinating polyneuropathy

Tunç

Tekeşin²,

Güzel

et al. 2020

Arq. Neuro-Psiquiatr.

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Background: Guillain-Barre syndrome is an acute immune-mediated polyneuropathy characterized by rapidly evolving symptoms and disability. Cerebrospinal fluid analysis and electrophysiological studies are crucial in the diagnosis of this syndrome. Objective: To evaluate the prognostic value of the type and number of demyelinating findings and cerebrospinal fluid protein levels in patients with acute inflammatory demyelinating polyneuropathy. Methods: We retrospectively analyzed electrophysiological data and cerebrospinal fluid of 67 consecutive patients with acute inflammatory demyelinating polyneuropathy from Istanbul, Turkey (2011-2019) studied ≤ 24 hours post-onset. Results: The patients who met a higher number of demyelinating criteria had increased disability scores in the first day and first month, and higher cerebrospinal fluid protein levels were correlated with worse prognosis both on the first day and the first month. However, the disability scores did not correlate with any single specific criterion, and no significant correlation was found between the number of satisfied criteria and cerebrospinal fluid protein levels. Conclusions: The number of demyelinating criteria that are met and high cerebrospinal fluid protein levels at the disease onset may be valuable prognostic markers. More systematic studies conducted with serial nerve conduction studies are required to highlight the roles of the suggested criteria in clinical practice.

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