Relationship between clinical parameters and cytokine profiles in inflamed gingival tissue and serum samples from patients with chronic periodontitis

Górska, Renata; Gregorek, Hanna; Kowalski, Jan; Laskus-Perendyk, Agnieszka; Syczewska, Małgorzata; Madaliński, K

doi:10.1046/j.0303-6979.2003.00425.x

Cited by 301 publications

(336 citation statements)

References 22 publications

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“…Our study demonstrated in patients with type 2 diabetes mellitus and chronic periodontitis high levels of cytokines of both, Th1 proinflammatory cytokines, represented by IL-17 and IFN-γ, and Th2 anti-inflammatory cytokines, which consisted of IL-4 and IL-10. Górska et al 22 reported that cytokines play a crucial role in immune and inflammatory responses and the balance between them can determine the outcome of periodontal infection.…”

Section: Discussionmentioning

confidence: 99%

“…Chronic periodontitis sites have shown increased levels of IL-17 in comparison with healthy periodontal tissues [18][19][20][21][22][23] and periodontal pathogens can stimulate the production of IL-17 from T-cells 19 . In this study, the concentration of the cytokine IL-17 was higher in patients with poorly controlled diabetes, confirming the Table 1.…”

Section: Discussionmentioning

confidence: 99%

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Glycemic control and the production of cytokines in diabetic patients with chronic periodontal disease

Franco

Moraes

Duarte

et al. 2017

RGO, Rev. Gaúch. Odontol.

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ObjectiveTo evaluate the association of glycemic control and cytokine production in type 2 diabetic subjects with chronic periodontitis Methods Gingival biopsies were performed in 40 patients, divided into four groups: systemically healthy subjects without periodontal disease (S); systemically healthy patients with chronic periodontitis (P); patients with well-controlled type 2 diabetes mellitus (DM) with chronic periodontitis (C); poorly controlled type 2 diabetes mellitus with chronic periodontitis (D). The production of interleukin (IL) -4, -6, -10, -17 and interferon (IFN) -γ was quantified by ELISA. Results The production of IL-4, IL-10, IL-17 and INF-γ was higher on group D when compared to other groups (p <0.05), which in turn were similar (p ≥0.05). In addition, there was no difference in the production of IL-6 in any of the evaluated groups (p≥0.05). ConclusionWere observed significantly elevated levels of pro-inflammatory and anti-inflammatory cytokines in patients with poorly controlled type 2 diabetes and chronic periodontitis, demonstrating that glycemic control may be associated to the immune inflammatory response of sites with chronic periodontitis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Glycemic control and the production of cytokines in diabetic patients with chronic periodontal disease

Franco

Moraes

Duarte

et al. 2017

RGO, Rev. Gaúch. Odontol.

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show abstract

“…Las citoquinas son polipéptidos reguladores que intervienen en la comunicación intercelular con un amplio espectro de propiedades inflamatorias, hematopoyéticas, metabólicas e inmunomoduladoras. Junto con sus receptores asociados forman una compleja red funcional de estricto control biológico, que incluye el feedback o retroalimentación 2,3 . Actúan regulando las células endoteliales y las moléculas de adhesión leucocitarias, hecho imprescindible para que los leucocitos abandonen los vasos sanguíneos y se infiltren en los tejidos circundantes.…”

Section: Resumen Resumen Resumen Resumenunclassified

<A NAME="top"></A>Papel de la IL-6 y TNF-alfa en la enfermedad periodontal

Sainz

Kass²,

Martínez³

2006

Avances en Periodoncia

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“…However, the individual's immune response to bacterial insult is responsible for the development or cessation of the disease, including a profile of the immune response regulated by different cytokines (3). Increased levels of immunoregulatory molecules, such as IL-1-b (interleukin-1 beta), IL-6 (interleukin-6), TNF (tumor necrosis factor) and PGE2 (prostaglandin E2), have been observed in periodontitis and periimplantitis sites compared with healthy sites (4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

MMP13, TIMP2 and TGFB3 Gene Polymorphisms in Brazilian Chronic Periodontitis and Periimplantitis Subjects

et al. 2016

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Subjects susceptible to chronic periodontitis (CP) show a high risk for the development of peiimplantitis (PI). Both diseases are multifactorial, presenting similarities in their pathophysiology and polygenic profile. MMP-13 (matrix metalloproteinases 13/ collagenase 3) is a collagenolytic enzyme, which expression is induced by TGF beta 3 (transforming growth factor type 3) in human gingival fibroblasts and inhibited by TIMP-2 (tissue inhibitor of metalloproteinase type 2). The aim of this study was to investigate the occurrence of peiimplantitis (PI) in subjects with history of chronic periodontitis (CP) and polymorphisms frequency in MMP13, TIMP2 and TGFB3 genes. One hundred and sixty-three volunteers received dental implant placement were submitted to oral and radiographic examination in order to identify past history of CP or presence of PI. Volunteers were divided into 4 groups: Control (without PI and CP, n=72), CP (with CP and without PI, n=28), PI (with PI and without CP, n=28) and diseased (with CP and PI, n=35). The chi-square test correlated genotypes in specific regions of MMP13 (rs2252070), TIMP2 (rs7501477) and TGFB3 (rs2268626) genes, considering the interaction between CP and PI. The results showed that volunteers with CP had 3.2 times more susceptibility to develop PI (p=0.0004) compared to those without CP. No significant association was observed in MMP13, TIMP2 and TGFB3 genes with CP or PI. CP is a risk factor to develop PI, however, there is no association of both diseases with polymorphisms in the MMP13, TIMP2 and TGFB3 genes. M M P 1 3 , T I M P 2 a n d T G F B 3 G e n e P o l y m o r p h i s m s i n Brazilian Subjects with Chronic Periodontitis and Periimplantitis

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Relationship between clinical parameters and cytokine profiles in inflamed gingival tissue and serum samples from patients with chronic periodontitis

Cited by 301 publications

References 22 publications

Glycemic control and the production of cytokines in diabetic patients with chronic periodontal disease

Glycemic control and the production of cytokines in diabetic patients with chronic periodontal disease

<A NAME="top"></A>Papel de la IL-6 y TNF-alfa en la enfermedad periodontal

MMP13, TIMP2 and TGFB3 Gene Polymorphisms in Brazilian Chronic Periodontitis and Periimplantitis Subjects

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