Relationship between colloid osmotic pressure and plasma protein concentration in the dog

Navar, P. D.; Navar, L. G.

doi:10.1152/ajpheart.1977.233.2.h295

Cited by 67 publications

(53 citation statements)

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“…In addition to changes in VP, edema formation depends on oncotic pressure 30. Even though it is very unlikely that protein applied at an amount as low as the one used in this study (50 μg RNase‐1/kg mouse) would influence intravasal oncotic pressure, we applied the same amount of DNase as a control; however, DNase did not reduce edema formation, indicating that a potential increase in the intravasal oncotic pressure following administration of this low amount of RNase‐1 may not be responsible for the observed effects.…”

Section: Discussionmentioning

confidence: 99%

Targeting of Extracellular RNA Reduces Edema Formation and Infarct Size and Improves Survival After Myocardial Infarction in Mice

Stieger

Daniel

Thölen

et al. 2017

JAHA

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BackgroundFollowing myocardial infarction (MI), peri‐infarct myocardial edema formation further impairs cardiac function. Extracellular RNA (eRNA) released from injured cells strongly increases vascular permeability. This study aimed to assess the role of eRNA in MI‐induced cardiac edema formation, infarct size, cardiac function, and survival after acute MI and to evaluate the therapeutic potential of ribonuclease 1 (RNase‐1) treatment as an eRNA‐degrading intervention.Methods and ResultsC57BL/6J mice were subjected to MI by permanent ligation of the left anterior descending coronary artery. Plasma eRNA levels were significantly increased compared with those in controls starting from 30 minutes after ligation. Systemic application of RNase‐1, but not DNase, significantly reduced myocardial edema formation 24 hours after ligation compared with controls. Consequently, eRNA degradation by RNase‐1 significantly improved the perfusion of collateral arteries in the border zone of the infarcted myocardium 24 hours after ligation of the left anterior descending coronary artery, as detected by micro–computed tomography imaging. Although there was no significant difference in the area at risk, the area of vital myocardium was markedly larger in mice treated with RNase‐1 compared with controls, as detected by Evans blue and 2,3,5‐triphenyltetrazolium chloride staining. The increase in viable myocardium was associated with significantly preserved left ventricular function, as assessed by echocardiography. Moreover, RNase‐1 significantly improved 8‐week survival following MI.ConclusionseRNA is an unrecognized permeability factor in vivo, associated with myocardial edema formation after acute MI. RNase‐1 counteracts eRNA‐induced edema formation and preserves perfusion of the infarction border zone, reducing infarct size and protecting cardiac function after MI.

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Section: Discussionmentioning

confidence: 99%

Targeting of Extracellular RNA Reduces Edema Formation and Infarct Size and Improves Survival After Myocardial Infarction in Mice

Stieger

Daniel

Thölen

et al. 2017

JAHA

View full text Add to dashboard Cite

show abstract

“…A significant albumin content in PM30 ultrafiltrate ( 5 %) has also been noted by Bisera, Weil, Michaels, Bernado, & Stein (1978 (Shaw, 1976) and mean 25-9 cmH2O (Bisera et al 1978). (Navar & Navar, 1977), mean 35 8 cmH2O (Bisera et al 1978). We were therefore confident of the validity of the COP measurements.…”

Section: Methodsmentioning

confidence: 99%

Relation Between Trans‐synovial Flow and Plasma Osmotic Pressure, With an Estimation of the Albumin Reflection Coefficient in the Rabbit Knee

1988

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SUMMARYThe volume of synovial fluid in a joint correlates inversely with plasma colloid osmotic pressure (COP). The inferred influence of plasma osmotic forces on trans-synovial flow was investigated directly here, in isolated perfused hindquarters of sixteen rabbits. Flow of intra-articularly infused Krebs solution across the synovial lining of the cannulated knee was recorded at controlled intra-articular pressure (18 cmH2O). Colloid osmotic pressure in the synovial microcirculation was varied by perfusion with oxygenated red cells resuspended in albumin solution or plasma from an extra-corporeal system at constant perfusion pressure. Studies in vitro showed that the COP versus concentration curve for commercial bovine albumin samples was variable and not reliably described by a widely used polynomial. The rate of trans-synovial absorption Qs was a positive linear function of intravascular COP T,, (r = 0-936, P < 0 001, n = 83). The average slope dQ,/dl7T was 0-20 ,ul min-' cmH20-' (S.E. + 0-01 lld min-, cmH201), the slope depending on hydraulic conductance and osmotic reflection coefficient. Transsynovial flow was a negative linear function of synovial capillary pressure (Pc). Absolute slope dQ,/d7Tp was on average only 78% of dQ8/dP, in the same joint. The osmotic reflection coefficient of the blood-joint barrier to serum albumin was estimated from these slopes as 0-78-0-81 (S.E.M. + 0 06). Vascular perfusion with a hyperosmolar solution of glucose, sucrose or NaCl generated a transient, rapidly decaying osmotic absorption from the joint cavity, with a half-life of 17-60 s. A reversed osmotic transient occurred on reperfusion with isotonic fluid. It was concluded that the blood-joint barrier, which comprises fenestrated endothelium and synovial intima, approximates to an imperfect semipermeable membrane for albumin solutions, justifying the application of Starling's hypothesis to trans-synovial flow. For small solutes the tissues form a highly permeable but nevertheless slightly osmotically reflective membrane.

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“…The albumin: globulin ratio of rats, dogs, and people were 1.4, 0.59, and 2.1, respectively, with corresponding differences in colloidal osmotic pressure. The latter was predicted to affect glomerular filtration dynamics (85).…”

Section: Factors That Can Influence Organ and Target Tissue Drug Delimentioning

confidence: 99%

Factors Influencing the Use and Interpretation of Animal Models in the Development of Parenteral Drug Delivery Systems

Martinez

2011

AAPS J

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Abstract. Depending upon the drug and drug delivery platform, species-specific physiological differences can lead to errors in the interspecies extrapolation of drug performance. This manuscript provides an overview of the species-specific physiological variables that can influence the performance of parenteral dosage forms such as in situ forming delivery systems, nanoparticles, microspheres, liposomes, targeted delivery systems, lipophilic solutions, and aqueous suspensions. Also discussed are those factors that can influence the partitioning of therapeutic compounds into tumors, the central nervous system and the lymphatics. Understanding interspecies differences in the movement and absorption of molecules is important to the interpretation of data generated through the use of animal models when studying parenteral drug delivery.

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Relationship between colloid osmotic pressure and plasma protein concentration in the dog

Cited by 67 publications

References 0 publications

Targeting of Extracellular RNA Reduces Edema Formation and Infarct Size and Improves Survival After Myocardial Infarction in Mice

Targeting of Extracellular RNA Reduces Edema Formation and Infarct Size and Improves Survival After Myocardial Infarction in Mice

Relation Between Trans‐synovial Flow and Plasma Osmotic Pressure, With an Estimation of the Albumin Reflection Coefficient in the Rabbit Knee

Factors Influencing the Use and Interpretation of Animal Models in the Development of Parenteral Drug Delivery Systems

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