Relationship between Cytokine Concentrations (FGF, sICAM‐1 and SCF) in Serum, Follicular Fluid and ICSI Outcome

Hammadeh, Mohamad Eid; Fischer-Hammadeh, C.; Hoffmeister, H.; Herrmann, Wolfgang; Rosenbaum, P.; Schmidt, Werner

doi:10.1046/j.8755-8920.2003.00121.x

Cited by 17 publications

(12 citation statements)

References 42 publications

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“…However, treatment of preovulatory oocytes with KITL did not improve the developmental capacity of mouse oocytes. Our data is consistent with previous findings demonstrating that the concentrations of KITL in the human follicular fluid did not associate with the fertilization rate and pregnant outcome in patients undergoing intracytoplasmic sperm injection [ 21 ]. Thus, the processes of nuclear and cytoplasmic maturation of the oocyte are independently regulated and could be controlled by different paracrine factors.…”

Section: Discussionsupporting

confidence: 93%

“…The dose range of KITL used in the present studies was similar to that used in the rat study[ 26 , 31 ]. Furthermore, the concentrations of KITL in human preovulatory follicular fluid were comparable to those levels[ 21 ]. Similar to the BDNF stimulation of first polar body extrusion, but not GVBD, it is apparent that sequential steps of nuclear maturation of the oocyte are controlled by different paracrine factors.…”

Section: Discussionmentioning

confidence: 99%

“…Either COCs or DOs were cultured with or without KITL to evaluate the effect of KITL on the transition from metaphase I (MI) stage to metaphase II (MII) stage oocytes. The doses of KITL for the present studies were based on the levels of KITL in human follicular fluid (560–660 pg/ml)[ 21 ] and those of other ovarian paracrine factors used in oocyte maturation studies[ 5 , 7 ]. COCs and DOs were obtained from mouse ovaries at 48 h after PMSG-treatment following isolation of preovulatory follicles and puncturing of the largest follicles as described above.…”

Section: Methodsmentioning

confidence: 99%

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Kit ligand promotes first polar body extrusion of mouse preovulatory oocytes

Kawamura

Sasaki

et al. 2009

Reprod Biol Endocrinol

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Background: Shortly after stimulation by the preovulatory surge of luteinizing hormone (LH), oocytes arrested at the late prophase I resume meiosis characterized by germinal vesicle breakdown (GVBD), chromosome condensation, and extrusion of the first polar body in preparation for fertilization and early embryonic development. However, oocytes express few or no LH receptors and are insensitive to direct LH stimulation. Thus, factors released by granulosa or theca cells expect to convey the LH stimuli to oocytes. To identify candidate ligand-receptor pairs potentially involved in the process of oocyte maturation, we performed DNA microarray analyses of ovarian transcripts in mice and identified Kit ligand (Kitl) as an ovarian factor stimulated by the LH/hCG surge. The purpose of this study is to investigate the roles of KITL in the nuclear and cytoplasmic maturation of preovulatory mouse oocytes.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Kit ligand promotes first polar body extrusion of mouse preovulatory oocytes

Kawamura

Sasaki

et al. 2009

Reprod Biol Endocrinol

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“…The level of basic FGF did not change in the FF around ovulation in women undergoing ovarian hyperstimulation for IVF therapy and there was no correlation between FF basic FGF levels and reproductive parameters with the exception of age [114]. No correlation could be found between ICSI outcome and FGF concentrations in serum or FF [115].…”

Section: Basic Fibroblast Growth Factormentioning

confidence: 77%

“…Consequently, elevated FF stem cell factor concentrations are associated with an increased likelihood of IVF success [157]. Hammadeh et al [115] found SCF concentrations either in FF or in serum were similar between patients who became pregnant after ICSI and those who did not.…”

Section: Stem Cell Factormentioning

confidence: 99%

Relationship between Cytokine Concentration in Serum and Preovulatory Follicular Fluid and in vitro Fertilization/Intracytoplasmic Sperm Injection Outcome

Hammadeh¹,

Fischer-Hammadeh²,

Amer³

et al. 2005

Chemical Immunology and Allergy, 2005

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Differences in follicle cell function and follicular fluid biochemistry have been suggested to influence the developmental potential of human oocytes at both cellular and chromosomal levels. Follicular fluids provide the environment in which oocyte maturation occurs. Therefore, follicular fluids may affect fertilization and early embryonic development. In humans, it has been shown that follicular fluid exerts chemotactic activity towards neutrophilic granulocytes and that the concentrations of this activity are related to the outcome of in vitro fertilization (IVF) treatment. The present study focuses on growth and cytokine presence in serum and follicular fluid of patients of reproductive age and their role in ovarian follicles, fertilization, embryo development, and implantation and to find out which growth factor could be a useful predictive parameter of IVF/intracytoplasmic sperm injection outcome.

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Cytokines in ovarian folliculogenesis, oocyte maturation and luteinisation

Field

Dasgupta

Cummings

et al. 2013

Molecular Reproduction Devel

166

110

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SUMMARYCytokines are key regulators of ovarian physiology, particularly in relation to folliculogenesis and ovulation, where they contribute to creating an environment supporting follicle selection and growth. Their manifold functions include regulating cellular proliferation/differentiation, follicular survival/atresia, and oocyte maturation. Several cytokines, such as TGF-b-superfamily members, are involved at all stages of folliculogenesis while the production of others is stage-dependent. This review draws upon evidence from both human and animal models to highlight the species-specific roles at each milestone of follicular development. Given these pivotal roles and their ease of detection in follicular fluid, cytokines have been considered as attractive biomarkers of oocyte maturational status and of successful assisted reproductive outcome. Despite this, our understanding of cytokines and their interactions remains incomplete, and is still frequently limited to overly simplistic descriptions of their interrelationships. Given our increased appreciation of cytokine activity in complex and highly regulated networks, we put forward the case for using Bayesian modelling approaches to describe their hierarchical relationships in order to predict causal physiological interactions in vivo.Mol. Reprod. Dev. 81: 284À314,

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Relationship between Cytokine Concentrations (FGF, sICAM‐1 and SCF) in Serum, Follicular Fluid and ICSI Outcome

Abstract: The concentration of FGF, sICAM-1, and SCF did not differ significantly between the two groups in serum or in FF. Besides, the ICSI outcome was not related to their concentrations in serum or FF. Therefore, these parameters could not be used as a prognostic factor in ICSI program.

Cited by 17 publications

References 42 publications

Kit ligand promotes first polar body extrusion of mouse preovulatory oocytes

Kit ligand promotes first polar body extrusion of mouse preovulatory oocytes

Relationship between Cytokine Concentration in Serum and Preovulatory Follicular Fluid and in vitro Fertilization/Intracytoplasmic Sperm Injection Outcome

Cytokines in ovarian folliculogenesis, oocyte maturation and luteinisation

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