Relationship between cytosolic calcium concentration and force in the papaverine‐induced relaxation of medial strips of pig coronary artery

Aoki, Hiroki; Nishimura, Junji; Kobayashi, Sei; Kobayashi, Hideo

doi:10.1111/j.1476-5381.1994.tb14763.x

Cited by 18 publications

(14 citation statements)

References 38 publications

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“…Its direct action on smooth muscle is thought to be primarily related to inhibition of cyclic adenosine monophosphate phosphodiesterases, but it may also have an effect on cyclic guanosine monophosphate phosphodiesterases. 1 Moreover, it probably exerts other actions, including calcium channel blockade, 14 adenosine blockade, 31 and an effect on protein kinase C. 15 Papaverine was chosen for two primary reasons. First, for this initial study of superselective pharmacological challenges, a practical consideration was to choose a drug with which we have had clinical experience.…”

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confidence: 99%

Superselective intraarterial papaverine administration: effect on regional cerebral blood flow in patients with arteriovenous malformations

Franco

Pile‐Spellman²,

Hacein‐Bey³

et al. 1996

Journal of Neurosurgery

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In this study the authors determined the effect of papaverine on regional cerebral blood flow (rCBF) in the angiographically normal arteriolar beds of patients with arteriovenous malformations (AVMs) who underwent transfemoral superselective angiography. Middle cerebral artery (MCA) branch vessels were catheterized during 10 procedures performed in nine patients. The mean (+/- standard deviation) largest AVM diameter was 4.4 +/- 1 cm. Regional CBF was measured by recording the washout of a bolus of xenon-133 injected through the microcatheter. In a dose-ranging study. rCBF and MCA pressure in two patients were repeatedly measured after 3-minute infusions of papaverine at 0.07, 0.7, and 7 mg/minute. In a single-dose study, an additional eight patients received only the highest dose of papaverine administered over a 3-minute period. In the dose-ranging study, CBF increased from baseline in a dose-dependent fashion. In the single-dose study, papaverine increased in rCBF 103%, from 48 +/- 11 to 95 +/- 23 ml/100 g/minute at an MCA pressure of 55 +/- 23 mm Hg. Increase in rCBF was linearly related (y = 2.2x - 17, r2 = 0.84; p = 0.001) to baseline MCA pressure (range 22-84 mm Hg). Papaverine increases rCBF in a direct proportion to baseline MCA pressure, even at low baseline pressures. Selective infusion of vasodilators should be investigated in acute cerebral hypotension to facilitate either primary or collateral recruitment of CBF by aiding spontaneous autoregulatory vasodilation. In addition, rCBF monitoring may be useful in determining the most effective intraarterial dose of papaverine while minimizing complications due to hyperemia.

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confidence: 99%

Superselective intraarterial papaverine administration: effect on regional cerebral blood flow in patients with arteriovenous malformations

Franco

Pile‐Spellman²,

Hacein‐Bey³

et al. 1996

Journal of Neurosurgery

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“…Tolazoline is a vasodilator acting in part through the stimulation of histamine release from mast cells and basophils and also by acting as an alpha‐adrenergic antagonist, although the specifics of the mechanism have not been definitively concluded . In contrast, papaverine, an opiate alkaloid, vasodilates blood vessels through a nonspecific inhibition of phosphodiesterases and also an inhibition of calcium channels …”

Section: Discussionmentioning

confidence: 99%

Vasomodulation Influences on the Transdermal Delivery of Ibuprofen

Carter

Zhu

Váradi

et al. 2013

Journal of Pharmaceutical Sciences

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“…This finding is in agreement with previous findings in iso[ated perfused lungs of rats and pigs (Cigarini et al, 1989, Roos el al., 1994, as weil as in systernic vessels (Ignarro el al., 1991). Although the smaller relaxant response of the veins could be due in part to the greater precontraction 10 U46619 (Stork and Cocks, 1994), this is unlikely because papaverine, that increases cytosolic cGMP content by inhibiting the activity of phosphodiesterase, independent of the endothelium and the NO pathway (Aoki et al, 1994;Kramer and Wells, 1979), relaxed arterles and veins equally. Thus after inhibition of the cyclooxygenase passway, the differences between arterles and veins in response ta ACh lie in the reduced responsiveness of the venous smooth muscle 10 NO, with a companent of the reduced ability of the venous endothelium to release NO.…”

Section: Discussionmentioning

confidence: 99%

Altered reactivity of pulmonary vessels in postobstructive pulmonary vasculopathy

Shi

Kassouf

et al. 2000

Journal of Applied Physiology

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This manuscript has baen reproduced trom the microfilm master. UMI films the text directly trom the original or copy submittad. Thus, sorne thesis and dissertation copies are in typewriter face, while others may be from any type of computer printer.The quality of this reproduction is dependent upon the quality of the copy submitted. Broken or indistinct print, colored or poor quality illustrations and photographs, print bleedthrough, substandard margins, and improper alignment can adversely affect reproduction.ln the unlikely avent that the author did not sand UMI a complete manuscript and there are missing pages, these will be noted. Also, if unauthorized copyright material had to be removed, a note will indicate the deletion.Oversize materials (e.g., maps, drawings, charts) are reproduced by sedioning the original, beginning at the upper left-hand corner and continuing tram left ta right in equal sections with small overlaps. Each original is also photographed in one exposure and is incJuded in reduced form at the back of the book.

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Relationship between cytosolic calcium concentration and force in the papaverine‐induced relaxation of medial strips of pig coronary artery

Abstract: 1The mechanisms of vasorelaxation induced by papaverine were investigated using front-surface fluorometry and fura-2-loaded medial strips of the pig coronary artery. 2 In the presence of extracellular Ca2+ (1.25 x 10-3 M), histamine (10-4 M)

Cited by 18 publications

References 38 publications

Superselective intraarterial papaverine administration: effect on regional cerebral blood flow in patients with arteriovenous malformations

Superselective intraarterial papaverine administration: effect on regional cerebral blood flow in patients with arteriovenous malformations

Vasomodulation Influences on the Transdermal Delivery of Ibuprofen

Altered reactivity of pulmonary vessels in postobstructive pulmonary vasculopathy

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