Relationship between dietary factors and recurrent aphthous stomatitis: A cross-sectional study

Xu, Kuo; Zhou, Chongchong; Fan, Heng; Duan, Ning; Wang, Yanyi; Zheng, Lichun; Wang, Xiang; Wang, Wenmei

doi:10.21203/rs.3.rs-89917/v1

Cited by 3 publications

(3 citation statements)

References 22 publications

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“…Recurrent aphthous ulcers (RAUs) with a high incidence rate have a serious impact on patients' nutrition, communication, and other daily activities (Giannetti et al, 2018). The prevalence of RAU worldwide ranges from 5% to 66% (Bratel and Hakeberg, 2014), and it is approximately 20% in China (Xu et al, 2021). At present, to reduce the occurrence frequency of RAU, clinicians commonly use therapeutic drugs that are mainly associated with regulating immune disorders (Guo et al, 2020;Zhang et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of total glucosides of paeony in the treatment of recurrent aphthous ulcers: a single-center, double-blind, randomized, placebo-controlled clinical trial

Liu

Guo

Li³

et al. 2023

Front. Pharmacol.

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Introduction: There has been a lack of treatments available to lower the frequency of recurrent aphthous ulcers (RAUs) until now. Total glucosides of paeony (TGP) is a botanical drug extracted from the dried roots of Paeonia lactiflora Pall. [Ranunculaceae; Paeoniae Radix Alba]. This study aims to evaluate the efficacy and safety of TGP in the treatment of RAU.Methods: This study was registered with the Chinese Clinical Trial Registry (ChiCTR1900025623). Patients were randomly assigned to the TGP or placebo group and treated with 1.8 g/day for 24 weeks. Participants were observed for a total of 36 weeks and were asked to record ulcer severity, medication, and adverse reactions in the form of diaries or apps every day. The primary outcome was the monthly ulcer-free interval.Results: A total of 79 individuals were enrolled, with 40 assigned to the TGP group and 39 to the placebo group. The dropout rate was 18.18%. In the TGP group, the monthly ulcer-free interval was significantly longer than baseline (median, 9.6 days) since weeks 13–24 (median, 18.5 days) (p < 0.05), and after discontinuation, it was further prolonged (median, 24.7 days) than in weeks 13–24 (p < 0.05). In addition, the monthly ulcer-free interval was longer in the TGP group than in the placebo group (median, 15.9 days) at weeks 25—36 (p < 0.001). There were better improvements in the monthly number of ulcers and monthly area of ulcers, and visual analog scoring in the TGP group at weeks 25—36 (p < 0.001).Conclusion: TGP had a good long-term therapeutic effect on RAU with frequent occurrence.Systematic Review Registration:www.chictr.org.cn, identifier ChiCTR1900025623.

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Section: Introductionmentioning

confidence: 99%

Efficacy and safety of total glucosides of paeony in the treatment of recurrent aphthous ulcers: a single-center, double-blind, randomized, placebo-controlled clinical trial

Liu

Guo

Li³

et al. 2023

Front. Pharmacol.

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“…The therapy that is highly recommended for RAS is topical corticosteroids, but the healing of RAS lesions is also dependent on the patient's systemic condition. In patients who have a low immune system, RAS healing will be delayed [7]. This supports that in addition to topical therapy, supportive therapy is also needed to accelerate the healing of the lesions.…”

Section: Introductionmentioning

confidence: 73%

Nutritional Therapy in the Treatment of Recurrent Aphthous Stomatitis: A Literature Review

Sari¹

2022

Advances in Health Sciences Research

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Recurrent aphthous stomatitis (RAS) is one of the most common oral diseases, with an estimated prevalence of 25% of oral ulcerations. Factors that involves in its progressions, such as genetic predisposition, immunological abnormalities, viral and bacterial infections, psychological stress, hormonal state, and nutritional deficiencies. Since the etiology and pathogenesis of RAS remain unclear, there is currently no consensus regarding a definitive curative therapy. However, nutritional improvement is thought to be able to support RAS healing optimally. This literature review aims to examine a few of the nutritional therapies which are usually given to support the treatment of RAS. The results obtained indicate that the nutritional therapy of RAS should be based on the detailed clinical history and possible underlying systemic causes along with complementary procedures such as laboratory tests, where required. The vitamins that are used most in the RAS are vitamin B12, folic acid, vitamin D, and zinc. There is little evidence regarding the effectiveness of the use of nutritional therapy in the treatment of RAS because most of the previous studies showed the comparison between the value of reduced vitamin levels in RAS patients and healthy individuals. Studies using nutritional/vitamin therapy as sole therapy in RAS patients are needed to be explored.

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“…Some of the vitamins and minerals found in vegetables and fruit function as antioxidants, and these can reduce the occurrence of disease or prevent the occurrence of lesions. 42…”

Section: Discussionmentioning

confidence: 99%

Predisposing Factors for Recurrent Aphthous Stomatitis among Undergraduate Dental Students

Rahmadhany

Mahdani

Surboyo

et al. 2022

Journal of Health and Allied Sciences NU

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Objectives The prevalence of recurrent aphthous stomatitis (RAS) among the general population worldwide is 20%. This study aims to discover any correlations between RAS predisposing factors and the gender and year of study of undergraduate dental students at the Faculty of Dental Medicine at Airlangga University. Methods A cross-sectional analytical study using simple random sampling was performed. The respondents answered seven questions on a self-reported online questionnaire set up using Google Forms. Chi-square analyses were conducted to determine any correlation between RAS predisposing factors and the gender and year of study of the students. Results The highest predisposing factors for RAS in undergraduate dental students were local trauma (77.7%) followed by stress (71.3%) and nutritional deficiencies (41.5%). Stress correlated strongly with the year of study (p = 0.015). There was no correlation between gender and RAS predisposing factors (p > 0.05). Conclusion There was a correlation between stress, one of the predisposing factors for RAS, and the year of study, but there was no correlation between gender and RAS predisposing factors including local trauma, stress, nutritional deficiency, genetics, allergies, and systemic diseases.

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Relationship between dietary factors and recurrent aphthous stomatitis: A cross-sectional study

Cited by 3 publications

References 22 publications

Efficacy and safety of total glucosides of paeony in the treatment of recurrent aphthous ulcers: a single-center, double-blind, randomized, placebo-controlled clinical trial

Efficacy and safety of total glucosides of paeony in the treatment of recurrent aphthous ulcers: a single-center, double-blind, randomized, placebo-controlled clinical trial

Nutritional Therapy in the Treatment of Recurrent Aphthous Stomatitis: A Literature Review

Predisposing Factors for Recurrent Aphthous Stomatitis among Undergraduate Dental Students

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