Relationship between elimination disorders and internalizing‐externalizing problems in children: A systematic review and meta‐analysis

Abstract

BackgroundElimination disorders are highly prevalent in childhood and often associated with clinically relevant comorbid psychological disorders. The aim of this study is to determine if, and to what extent, children with elimination disorders show higher internalizing and externalizing problems than their healthy peers.MethodsA multistep literature search was performed from database inception until May 1st, 2022. PRISMA/MOOSE‐compliant systematic review (PROSPERO: CRD42022303555) were used to identify studies reporting on internalizing and/or externalizing symptoms in children with an elimination disorder and a healthy control (HC) group. First, a systematic review was provided. Second, where data allowed for it, a quantitative meta‐analysis with random effects model was conducted to analyze the differences between the elimination disorder and the HC groups for internalizing and externalizing symptoms. Effect size was standardized mean difference. Meta‐regression analyses were conducted to examine the effect of sex, age, and study quality. Funnel plots were used to detect a publication bias. Where found, the trim and fill method was used to correct it.Results36 articles were included, 32 of them reporting on enuresis (n = 3244; mean age = 9.4; SD = 3.4; 43.84% female) and 7 of them on encopresis (n = 214; mean age = 8.6; SD = 2.3; 36.24% female). Children with an elimination disorder presented significantly lower self‐concept (ES:0.42; 95%CI [0.08; 9.76]; p = 0.017) and higher symptom scores for thought problems (ES:−0.26; 95%CI: −0.43;−0.09]; p = 0.003), externalizing symptoms (ES: −0.20; 95%CI [−0.37;−0.03]; p = 0.020), attention problems (ES:−0.37; 95%CI [−0.51;−0.22]; p = 0.0001), aggressive behavior (ES:−0.33; 95%CI [−0.62;−0.04]; p = 0.025) and social problems (ES:−0.39; 95%CI [−0.58;−0.21]; p = 0.0001). Significant publication biases were found across several of the studied domains. No significant effect of sex, age or quality of the study score was found.ConclusionsChildren with an elimination disorder may have significant internalizing and externalizing problems, as well as impaired self‐concept. It is recommendable to screen for them in children with enuresis or encopresis and provide appropriate interventions.

Evidence‐based child and adolescent mental health care: The role of high‐quality and transparently reported evidence synthesis studies

“…An important focus of the studies in the special issue is on outcomes and prognosis, such as those demonstrating an association between Attention-Deficit/Hyperactivity Disorder (ADHD) and cardiovascular problems (Li et al, 2023) and sleep problems (Marten et al, 2023), as well as for poor health-related quality of life associated with low socio-economic status amongst children and adolescents with ADHD (Sevastidis et al, 2023). Bogdan et al (2023) presented a comprehensive summary of the main characteristics of longitudinal studies investigating child and adolescent mental health conditions in the general population; Aymerich et al (2023) found that internalising and externalising problems are present in children with enuresis or encopresis; while Pollard et al (2023) observed that anxiety problems during childhood are associated with multifaceted poor outcomes and considerable economic costs.…”

“…( 2023 ) presented a comprehensive summary of the main characteristics of longitudinal studies investigating child and adolescent mental health conditions in the general population; Aymerich et al. ( 2023 ) found that internalising and externalising problems are present in children with enuresis or encopresis; while Pollard et al. ( 2023 ) observed that anxiety problems during childhood are associated with multifaceted poor outcomes and considerable economic costs.…”