Relationship between epicardial fat volume measured by multi-detector computed tomography and coronary artery disease

Taha, Doaa Ashour; Shafey, Rasha Ahmed Ali El; Hamesa, Manal; Abu-Dewan, Khaled Abd El-Wahab; Nagy, Hanan Ahmad

doi:10.1186/s43055-021-00615-w

Cited by 5 publications

(6 citation statements)

References 24 publications

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“…A statistically significance (p<0.001) showed a strong relation with level of Ca score with severity and grading of CAD. A study found that here was significant difference between both groups as regard epicardial fat volume (p < 0.001), and good relation was found between the amount of epicardial fat volume and coronary calcium score, number of affected vessel, plaque burden and degree of stenosis (p < 0.001) (14) . ROC curve of EFV was conducted for prediction of CAD disease activity.…”

Section: Discussionmentioning

confidence: 66%

“…Also, a study on 120 patients, 22 patients were negative for CAD, while 98 patients had positive CAD. They found that there was significant difference between negative CTA patients and positive CTA patients as regard epicardial fat volume (p < 0.001) (14) . The mean Calcium score in non-CAD group was 31.28±64.77 and 208.57±89.40 for the CAD group.…”

Section: Discussionmentioning

confidence: 97%

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Diagnostic value of Multi Detector Computed Tomography in Assessment of Epicardial Adipose Tissue with Coronary Artery Disease

Refaat,

Abo Elezz,

Helmy

et al. 2023

Benha Medical Journal

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Background: Current Multi Detector Computed Tomography (MDCT) systems allow the visualization of the entire heart volume during an entire heart cycle with high density resolution. MDCT imaging is thus opened to a wide spectrum of cardiac applications. This study aimed to evaluate the diagnostic value of multi detector computed tomographic in assessment of epicardial adipose tissue with coronary artery disease. Methods: This Prospective, non-controlled nonrandomized study was conducted on 75 patients who underwent CT angiogram due to acute coronary syndrome occurrence. For further assessment of CAD patients divided into two groups: non-CAD group: 25 subjects with normal coronary arteries and CAD group: 50 subjects with coronary artery lesion. Results: This study included 75 patients; their mean age was 61.85 years. 61% of the studied subjects were males and 38% were females. ROC curve of EFV was conducted for prediction of CAD disease activity. EFV showed 0.813 area under curve at cut off level 60.39 with good sensitivity and specificity. ROC curve of Ca score was conducted for prediction of CAD disease activity. Ca score showed 0.947 area under curve at cut off level 90 with high sensitivity and specificity. Conclusion:The EAT volume has good prognostic value for developing CAD and increased EAT is considered a risk factor for CAD. Ca score could have an appropriate prognostic value for the determination of coronary artery disease.

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Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 97%

Diagnostic value of Multi Detector Computed Tomography in Assessment of Epicardial Adipose Tissue with Coronary Artery Disease

Refaat,

Abo Elezz,

Helmy

et al. 2023

Benha Medical Journal

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“…Due to its high spatial resolution, dedicated software and post-processing techniques, CCT is the method of choice [19]. In the literature, the attenuation thresholds for post-contrast CCT epicardial fat identification are variable and usually range from −250/−190 HU, as regards the lower limit, to −50/−5 HU for the upper threshold, with intermediate values between the limit values [20][21][22].…”

Section: Discussionmentioning

confidence: 99%

Epicardial Adipose Tissue Changes during Statin Administration in Relation to the Body Mass Index: A Longitudinal Cardiac CT Study

Toia,

La Grutta,

Vitabile

et al. 2023

Applied Sciences

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The epicardial adipose tissue (EAT) is the visceral fat located between the myocardium and the pericardium. We aimed to perform a longitudinal evaluation of the epicardial adipose tissue using an advanced computer-assisted approach in a population of patients undergoing Cardiac CT (CCT) during statin administration, in relation to their body mass index (BMI). We retrospectively enrolled 95 patients [mean age 62 ± 10 years; 68 males (72%) and 27 females (28%)] undergoing CCT for suspected coronary artery disease during statin administration. CCT was performed at two subsequent time points. At the second CCT, EAT showed a mean density increase (−75.59 ± 7.0 HU vs. −78.18 ± 5.3 HU, p < 0.001) and a volume decrease (130 ± 54.3 cm3 vs.142.79 ± 56.9 cm3, p < 0.001). Concerning coronary artery EAT thickness, a reduction was found at the origin of the right coronary artery (13.26 ± 5.2 mm vs. 14.94 ± 5.8, p = 0.001) and interventricular artery (8.22 ± 3.7 mm vs. 9.13 ± 3.9 mm, p = 0.001). The quartile (Q) attenuation percentage (%) distribution of EAT changed at the second CCT. The EAT % distribution changed by the BMI in Q1 (p = 0.015), Q3 (p = 0.001) and Q4 (p = 0.043) at the second CCT, but the normal-BMI and overweight/obese patients showed a similar response to statin therapy in terms of quartile distribution changes. In conclusion, statins may determine significant changes in EAT quantitative and qualitative characteristics detected by CCT; the BMI influences the EAT composition, but statins determine a similar response in quartile distribution’s variation, irrespective of the BMI.

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“…Recently, EAT volume (EATV) has been recognized as an independent predictor of vulnerable plaques in coronary arteries and is believed to have strong predictive ability (3,7). Multislice spiral computed tomography (CT) has become the preferred method for measuring EATV because of its high spatial resolution, high scanning speed, and reproducibility (8,9). Most studies on the association between EATV and coronary arteriosclerosis have relied on coronary CT angiography (CTA) (10,11).…”

Section: Introductionmentioning

confidence: 99%

Quantification of epicardial fat volume using low-dose cardiac scan in patients with low calcium score

Ji¹,

Lin²,

Deng³

et al. 2023

Quant Imaging Med Surg

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Background: We investigated the accuracy of quantifying epicardial adipose tissue volume (EATV) using low-dose cardiac scan (EATV cardiacscan ) and evaluated its clinical utility in predicting coronary heart disease in patients with low or mild calcification.Methods: In total, 204 patients with clinical symptoms of coronary heart disease and coronary artery calcium score (CACS) of <100 AU were enrolled in this retrospective study. After obtaining EATV cardiacscan and EATV measured using computed tomography angiography (EATV CTA ), the agreement between the two measurements was evaluated using Pearson correlation coefficient and Bland-Altman analysis. Multivariate logistic regression was used to analyze the utility of EATV in predicting plaque and vulnerable plaque.Receiver operating characteristic curves were constructed. Results:The mean EATV cardiacscan (101.51±41.57 cm 3 ) and EATV CTA (104.57±41.34 cm 3 ) of all patients were similar, and the two measurements were strongly correlated (r=0.9596, P<0.001). The difference between EATV cardiac scan and EATV CTA was −3.0549, with only 4.9% (10/204) of patients having values outside the 95% confidence interval (CI) range (−26.15 to 20.04; P for agreement =0.0003). Further, a significant agreement was observed between EATV cardiac scan and EATV CTA in 126 patients with plaques, with an estimated difference of −3.354, and 6.35% (8/126) of patients had values outside the 95% CI range (−31.37 to 24.66; P for agreement =0.0095). After adjustment for age and sex, EATV cardiac scan and EATV CTA were significantly associated with plaque (all P values <0.001), and the areas under the curve (AUCs) were 0.662 and 0.670 (P=0.4331), respectively. In contrast, EATV cardiac scan and EATV CTA were not associated with vulnerable plaque (P>0.05), with AUCs of 0.550 and 0.530, respectively (P=0.2157). Conclusions:The study results indicate that EATV cardiac scan and EATV CTA are equivalent. In addition, both methods provide comparable values for predicting coronary arteriosclerosis in patients with low-to-mild calcification (CACS of <100 AU).

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Relationship between epicardial fat volume measured by multi-detector computed tomography and coronary artery disease

Cited by 5 publications

References 24 publications

Diagnostic value of Multi Detector Computed Tomography in Assessment of Epicardial Adipose Tissue with Coronary Artery Disease

Diagnostic value of Multi Detector Computed Tomography in Assessment of Epicardial Adipose Tissue with Coronary Artery Disease

Epicardial Adipose Tissue Changes during Statin Administration in Relation to the Body Mass Index: A Longitudinal Cardiac CT Study

Quantification of epicardial fat volume using low-dose cardiac scan in patients with low calcium score

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