Relationship between Epstein-Barr Virus (EBV) İnfection and Viral Load in İmmunosuppressive Patients

Çolak, Meryem; Altay-Kocak, Aylin; Dalgıç, Buket; Fidan, Işıl; Özkan, Seçil; Pinar, Ahmet; Bozdayı, Gülendam

doi:10.5152/imj.2018.93357

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a systematic review and meta-analysis, using 11 metagenomic studies, the EBV plus CMV was determined as a significant cause of IBD (Marongiu et al 2022 ). The EBV infecting B cells has been involved in a variety of autoimmune diseases and cancers (Çolak et al 2018 ; Caetano et al 2021 ; Wallaschek et al 2021 ). Fatal lymphoproliferative disease is caused following viral reactivation mainly among immunosuppressed and vulnerable populations (Vockerodt et al 2015 ).…”

Section: Methodsmentioning

confidence: 99%

Protective role of flavonoids quercetin and silymarin in the viral-associated inflammatory bowel disease: an updated review

Zarenezhad

Abdulabbas

Kareem³

et al. 2023

Arch Microbiol

View full text Add to dashboard Cite

Inflammatory bowel disease (IBD) is a chronic recurrent inflammation of the gastrointestinal tract (GIT). IBD patients are susceptible to various infections such as viral infections due to the long-term consumption of immunosuppressive drugs and biologics. The antiviral and IBD protective traits of flavonoids have not been entirely investigated. This study objective included an overview of the protective role of flavonoids quercetin and silymarin in viral-associated IBD. Several viral agents such as cytomegalovirus (CMV), Epstein–Barr virus (EBV), varicella zoster virus (VZV) and enteric viruses can be reactivated and thus develop or exacerbate the IBD conditions or eventually facilitate the disease remission. Flavonoids such as quercetin and silymarin are non-toxic and safe bioactive compounds with remarkable anti-oxidant, anti-inflammatory and anti-viral effects. Mechanisms of anti-inflammatory and antiviral effects of silymarin and quercetin mainly include immune modulation and inhibition of caspase enzymes, viral binding and replication, RNA synthesis, viral proteases and viral assembly. In the nutraceutical sector, natural flavonoids low bioavailability and solubility necessitate the application of delivery systems to enhance their efficacy. This review study provided an updated understanding of the protective role of quercetin and silymarin against viral-associated IBD.

show abstract

Section: Methodsmentioning

confidence: 99%

Protective role of flavonoids quercetin and silymarin in the viral-associated inflammatory bowel disease: an updated review

Zarenezhad

Abdulabbas

Kareem³

et al. 2023

Arch Microbiol

View full text Add to dashboard Cite

show abstract

“…EBV, a herpes virus that infects 95 percent of the world's population, spreads through bodily fluids and blood [38]. The EBV, particularly well-known for infecting B cells, is linked to several cancers and autoimmune diseases and can cause inflammatory diseases such as Crohn's disease Human papilloma virus (HPV) non-enveloped double-stranded DNA viruses…”

Section: Epstein-barr Virus (Ebv)mentioning

confidence: 99%

Association Between Inflammatory Bowel Disease and Viral Infections

et al. 2023

View full text Add to dashboard Cite

Chronic inflammatory gastrointestinal diseases such as Crohn's disease (CD) and ulcerative colitis (UC) are known as inflammatory bowel disorders (IBD). Patients with inflammatory bowel illnesses are more susceptible to viral infections. In people with IBD, viral infections have emerged as a significant issue. Viral infections are often difficult to identify and have a high morbidity and fatality rate. We reviewed studies on viral infections and IBD, concentrating on Cytomegalovirus (CMV), SARS-CoV-2, Epstein-Barr virus (EBV), enteric viruses, and hepatitis B virus (HBV). Also, the effect of IBD on these viral infections is discussed. These data suggest that patients with IBD are more likely to get viral infections. As a result, practitioners should be aware of the increased risk of viral infections in inflammatory bowel disease patients.

show abstract

Relationship between Epstein-Barr Virus (EBV) İnfection and Viral Load in İmmunosuppressive Patients

Cited by 2 publications

References 0 publications

Protective role of flavonoids quercetin and silymarin in the viral-associated inflammatory bowel disease: an updated review

Protective role of flavonoids quercetin and silymarin in the viral-associated inflammatory bowel disease: an updated review

Association Between Inflammatory Bowel Disease and Viral Infections

Contact Info

Product

Resources

About