Relationship between exhaled nitric oxide and atopy in Asian young adults

Chng, Seo Yi; Bever, Hugo P. Van; Lian, Derrick Wq; Lee, Shan Xian; Xu, X.; Wang, Xiao Shan; Goh, Daniel Yam Thiam

doi:10.1111/j.1440-1843.2005.00628.x

Cited by 21 publications

(18 citation statements)

References 34 publications

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“…Atopy was not an independent determinant for FeNO levels in our study population in contrast to the results of previous studies 21,22,29. A previous study with the Korean population conducted by Kim et al15 in indicated that atopy (alongside gender) is a significant predictor of FeNO levels.…”

Section: Discussioncontrasting

confidence: 97%

“…Travers et al21 suggested a mean FeNO of 17.9 ppb in healthy New Zealander adults (n=193, mean age=56.3±12.9, atopy rate=23.8%), and Olin et al28 showed a FeNO level of 16.6 ppb in healthy Swedish adults (n=1,131; mean age, 50.3±13.81; atopy rate, 25.3%). In Asia, Chng et al29 presented a median FeNO level of 38.4 ppb for atopic subjects and 15.7 ppb for non-atopic subjects in Singaporeans (n=45, mean age, 19.6; atopy rate, 61.8%); however, their subjects were younger than ours. We speculate that the reason for our lower FeNO ranges (than other ethnic groups) may be due to differences in living environment.…”

Section: Discussioncontrasting

confidence: 58%

“…It is well-known that living in rural areas exerts a protective effect on asthma or atopy,31,32,33 as suggested by the 'hygiene hypotheses'. The participants of previous studies were mostly recruited from urban areas 5,21,28,29…”

Section: Discussionmentioning

confidence: 99%

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Reference Ranges and Determinant Factors for Exhaled Nitric Oxide in a Healthy Korean Elderly Population

Song

Kim

et al. 2014

Allergy Asthma Immunol Res

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PurposeExhaled nitric oxide (NO) is a useful non-invasive biomarker for asthma diagnosis; however, the literature suggests that exhaled NO levels may be affected by demographic factors. The present analysis investigated determinant factors that present exhaled NO reference levels for Korean elderly adults.MethodsFor reference levels, we analyzed the baseline data of healthy adult participants in the Ansung cohort. The fraction of exhaled NO (FeNO) was measured by NIOX MINO®. The characterization of the subjects was performed through structured questionnaires, spirometry, and methacholine challenge tests. To validate the diagnostic utility of the determined reference levels, asthma patients were recruited from medical institutions for FeNO measurement.ResultsA total of 570 healthy subjects were analyzed (mean age, 59.9±12.3; male, 37.0%) for reference levels. FeNO levels significantly correlated with weight, height, body mass index, atopy, or forced expiratory volume in 1 second % predicted by simple linear regression analysis. Multiple linear regression analysis identified gender as an independent determinant for FeNO levels; subsequently, the reference values for FeNO were 18.2±10.6 ppb (5th to 95th percentile, 6.0 to 37.4 ppb) for males and 12.1±6.9 ppb (5th to 95th percentile, 2.5 to 27.0 ppb) for females. The diagnostic utility of FeNO reference levels was validated by receiver operating curve analysis (area under curve, 0.900 for males and 0.885 for females) for diagnosing asthma. The optimal cutoff values for the prediction of asthma were 30.5 ppb for males and 20.5 ppb for females.ConclusionsThe current analysis presented reference ranges and the diagnostic utility of FeNO levels for asthma in Korean elderly adults.

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Section: Discussioncontrasting

confidence: 97%

Section: Discussioncontrasting

confidence: 58%

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Reference Ranges and Determinant Factors for Exhaled Nitric Oxide in a Healthy Korean Elderly Population

Song

Kim

et al. 2014

Allergy Asthma Immunol Res

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“…A recent study from Taiwan involving 681 Asian children aged 5-18 years found that the geometric mean FeNO and the upper 95% CI were 13.7 and 29.7 ppb, respectively, and this was also higher when compared with the Caucasian population [30]. In fact, other smaller-scale studies involving Chinese and Korean adults also showed a similar level of FeNO value to our study (table 4) [25][26][27]. A study involving 895 African-Americans noted that the mean FeNO for males and females were 27¡26 ppb and 18¡18 ppb, respectively [31].…”

Section: Discussionsupporting

confidence: 86%

“…This factor might not be very significant as all current machines should follow the ATS/ERS guidelines [2,3] for calibration and maintenance. Conversely, a study from Singapore using the NIOX machine in testing 45 first-year Asian medical students and another study from Korea involving 166 adults aged 20-80 years using the same Sievers machine as in this study [26], found similar FeNO values to our study [25].…”

Section: Discussionsupporting

confidence: 79%

Determinants of, and reference equation for, exhaled nitric oxide in the Chinese population

Leung

Wong

et al. 2012

Eur Respir J

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Measurement of fractional exhaled nitric oxide concentration (FeNO) has been proposed as a useful biomarker for monitoring and management of airway diseases. Limited information is available regarding reference levels of FeNO levels in Chinese adults. This study aimed to investigate the reference equation and determinants of FeNO in Chinese adults.1093 (577 males) healthy nonsmoking subjects aged 18-90 years were recruited. FeNO was measured online using a chemiluminescence analyser. Other assessments included spirometry, skin prick tests, total serum IgE levels and eosinophil count in peripheral blood.The geometric mean FeNO was 32.6 (95% reference interval (RI) 31. log(FeNO) 5 0.781 + 0.104(sex) + 0.004(age) + 0.084(atopy) + 0.003(height in cm), where for sex 15male and 05female, age is measured in years, for atopy 15atopic and 05nonatopic, and height is measured in cm.The FeNO of Chinese adults is higher than that of the Caucasian population, and is affected by age, sex, height and atopic status. This study provides useful references for the interpretation of FeNO. @ERSpublications Exhaled NO fraction in Chinese adults is higher than in Caucasians, and is affected by age, sex, height and atopy

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Aeroallergen sensitization in childhood asthmatics in Northern India

et al. 2013

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Relationship between exhaled nitric oxide and atopy in Asian young adults

Abstract: Increased FE(NO) levels are more reflective of atopy rather than asthma, and increased nitric oxide production may be predominantly a feature of atopy in asthmatics.

Cited by 21 publications

References 34 publications

Reference Ranges and Determinant Factors for Exhaled Nitric Oxide in a Healthy Korean Elderly Population

Reference Ranges and Determinant Factors for Exhaled Nitric Oxide in a Healthy Korean Elderly Population

Determinants of, and reference equation for, exhaled nitric oxide in the Chinese population

Aeroallergen sensitization in childhood asthmatics in Northern India

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