Relationship between expression of matrix metalloproteinase-9 and adenylyl cyclase-associated protein 1 in chronic obstructive pulmonary disease

Xie, Shuanshuan; Hu, Feng; Tong, Min; Duan, Yunyun; Song, Xiaolian; Wang, Changhui

doi:10.1177/0300060514548290

Cited by 10 publications

(10 citation statements)

References 21 publications

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“…Somewhat surprisingly and apparently in contrast to other authors [ 23 , 27 , 34 ] we could not correlate the levels of MMPs measured in bronchial fluid with the presence or absence of COPD. However, taking a closer look in one study [ 27 ], no information was provided regarding the smoking status of the study participants. In another study [ 23 ], which investigated the levels of MMP8, MMP9 and MMP12 in the induced sputum, only MMP8 was higher in symptomatic smokers with COPD Stage GOLD 0 compared to non-symptomatic smokers.…”

Section: Discussioncontrasting

confidence: 99%

“…MMPs seem to represent important peptides and markers in both, the pathogenesis of lung diseases [ 7 , 9 , 27 , 28 ] and periodontitis [ 5 , 25 , 29 ]. Therefore, in the current study MMP2, aMMP8, MMP9 and MMP12 were measured in the bronchial fluid of 91 patients undergoing elective diagnostic bronchoscopy and these findings correlated with the presence of periopathogenic marker species.…”

Section: Discussionmentioning

confidence: 99%

“…Although increased levels of MMP8 and MMP9 of bronchoalveolar lavage fluid in earlier studies have been associated with severe infectious conditions such as ventilator associated pneumonias [ 7 , 33 ],the exact role of MMPs in inflammatory diseases of the lung is not yet understood. Data concerning levels of MMPs and development or progression of COPD for example, are conflicting [ 27 , 34 ]. Cell surface lipopolysaccharides of Td that bind to extracellular matrix components of the periodontal tissue seem to induce pro-inflammatory pathways, which eventually contribute to the development of periodontitis [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

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Elevated Matrix Metalloproteinase Levels in Bronchi Infected with Periodontopathogenic Bacteria

et al. 2015

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ObjectivesTo determine whether bronchial colonisations/infections with periodontopathogenic bacteria are associated with elevated inflammatory markers such as MMPs, interleukins and Tumor necrosis factor alpha in the bronchial fluid.MethodsPeriodontal status was assessed in consecutive outpatients planned for elective bronchoscopies, and PCR for periodontopathogenic bacteria was performed from a protected specimen brush sample taken from the bronchial mucosa. Additionally, MMPs, interleukins and Tumor necrosis factor alpha were measured in the bronchial fluid.ResultsOut of the four species assessed, one species was found in 13 of 91 (14%) patients, and two in 12 (13%), three in 13 (14%) and all four in 1 (1%) patient, respectively. In multiple linear regression models the presence of Treponema denticola showed a consistent pattern of positive effects in bronchial fluid (Bonferroni adjusted p-values) on the levels of MMP9 (p adj.: 0.028) and MMP12 (p adj.: 0.029). Active smoking was independently associated with increased levels of aMMP8 (p adj.: 0.005) and MMP9 (p adj.: 0.009). Levels of IL-1 ß, IL-8 and Tumor necrosis factor alpha measured in the bronchial fluid were not affected by the presence of periodontopathogenic bacteria.ConclusionsBronchial colonisation/infection with Treponema denticola and smoking are independently associated with elevated MMPs (MMP9/MMP12 and MMP8/MMP9, respectively) in the bronchial fluid.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Elevated Matrix Metalloproteinase Levels in Bronchi Infected with Periodontopathogenic Bacteria

et al. 2015

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“…27 and high levels of MMP-9 and lower levels of CAP1 have been observed in chronic obstructive pulmonary disease. 28 A number of publications have demonstrated that hormone receptors and G protein-coupled receptors (GPCRs) activate MMP-9. [29][30][31] Recent research has also revealed that extracellular amino acids can be sensed by plasma membrane receptors, such as GPRC6A and GPCR T1R1/T1R3, and regulate mTOR.…”

Section: Figurementioning

confidence: 99%

Cyclase‐associated protein 1 is a key negative regulator of milk synthesis and proliferation of bovine mammary epithelial cells

Yuan

Zhen

Zhang

et al. 2019

Cell Biochemistry & Function

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Adenylyl cyclase-associated protein (CAP) is a highly conserved protein. Previous reports have suggested that CAP1 may be a negative regulator of cellular proliferation, migration, and adhesion and the development of cell carcinomas. The molecular mechanism of CAP1 regulation of downstream pathways, as well as how CAP1 is regulated by environmental stimuli and upstream signalling, is not well understood. In this present study, we assessed the role of CAP1 in milk synthesis and proliferation of bovine mammary epithelial cells. Using gene overexpression and silencing methods, CAP1 was found to negatively regulate milk synthesis and proliferation of cells via the PI3K-mTOR/SREBP-1c/Cyclin D1 signalling pathway. Hormones, such as prolactin and oestrogen, and amino acids, such as methionine and leucine, stimulate MMP9 expression and trigger CAP1 degradation, and thus, abrogate its inhibition of synthesis of milk protein, fat, and lactose by and proliferation of bovine mammary epithelial cells.The results of our study help deepen our understanding of the regulatory mechanisms underlying milk synthesis and aid in characterizing the molecular mechanisms of CAP1.Previous reports have suggested that CAP1 is a negative regulator of cellular proliferation and anabolism, but the molecular mechanisms are largely unknown. In this present study, we identified CAP1 as a negative regulator of milk synthesis and proliferation of bovine mammary epithelial cells. Our results will deepen our understanding of the regulatory mechanisms underlying milk synthesis and aid in exploring the molecular mechanisms of CAP1.

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“…Как уже сообщалось выше, в процессах сборки ламеллоподий участвует множество различных белков. Так, например, показано, что экспрессия ММР-9 эпителиальными клетками дыхательных путей связана с экспрессией CAP-1 [68], белка семейства аденилилциклазаассоциированных протеинов (Catabolite Gene Activator Protein, САР), относящихся к актинсвязывающим белкам, которые принимают участие в регуляции актинового цитоскелета и Ras/cAMPсигнального пути. Предполагаемый механизм участия CAP-1 в регуляции подвижности клеток -комплекси-рование с талином (белком, прикрепляющим актин к мембране) и киназой фокальных контактов (FAK) [2,3], активность которой сопряжена с увеличением синтеза MMР [69,70].…”

Section: внеклеточный протеолизunclassified

Degradome Components in Progression of Squamous Cell Carcinoma of the Head and Neck

2015

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The process of tumor progression is closely related to the intracellular, extracellular and intramembranous proteolysis. Many studies indicate that the proteases function as part of an extensive multidirectional network of proteolytic interactions. Disturbance of strictly controlled equilibrium of the proteolytic system is described in a number of diseases, including cancer. The paper presents a review of the available data concerning the contribution of intracellular, extracellular and intramembrane proteolysis to the process of squamous cell head and neck carcinoma. Specific mechanisms of interaction of different proteolytic systems in cancer progression both in general and in squamous cell head and neck carcinoma remain underinvestigated. The versatility of functions and complexity of the relationships between proteolytic systems highlights the importance of studying the participation of all degradome components in tumor progression that may clarify the multi-link complex mechanisms of carcinogenesis of squamous cell head and neck carcinoma and to identify markers of progression and/or a targets for therapeutic intervention.

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Relationship between expression of matrix metalloproteinase-9 and adenylyl cyclase-associated protein 1 in chronic obstructive pulmonary disease

Cited by 10 publications

References 21 publications

Elevated Matrix Metalloproteinase Levels in Bronchi Infected with Periodontopathogenic Bacteria

Elevated Matrix Metalloproteinase Levels in Bronchi Infected with Periodontopathogenic Bacteria

Cyclase‐associated protein 1 is a key negative regulator of milk synthesis and proliferation of bovine mammary epithelial cells

Degradome Components in Progression of Squamous Cell Carcinoma of the Head and Neck

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